| Acknowledgements | 第1-6页 |
| Dedication | 第6-7页 |
| Abstract | 第7-10页 |
| 摘要 | 第10-12页 |
| Abbreviations | 第12-22页 |
| Chapter 1: General Introduction and Review of the Literature | 第22-36页 |
| ·Vitamin E background | 第22页 |
| ·Chemistry of Vitamin E | 第22-23页 |
| ·Current insights into Vitamin E nanoemulsions formulation,production and their challenges | 第23-27页 |
| ·Development of VE delivery systems | 第23-24页 |
| ·Oil in Water VE based Emulsions,Nanoemulsions and Microemulsions | 第24-25页 |
| ·Conventional emulsions vs.nanoemuls | 第25-27页 |
| ·Methods of fabrication of VE based nanoemulsions | 第27-28页 |
| ·High-energy approaches | 第27-28页 |
| ·Low energy approaches | 第28页 |
| ·Emulsifiers/surfactants | 第28-30页 |
| ·OSA modified starches as emulsifiers | 第29-30页 |
| ·The Stability of Vitamin E based Nanoemulsions | 第30页 |
| ·Statement of the problem and justification of research | 第30-31页 |
| ·Objectives of the research | 第31-32页 |
| ·Main objective | 第31页 |
| ·Specific objectives | 第31-32页 |
| References | 第32-36页 |
| Chapter 2: High-energy emulsification:Process optimization,preparation and stabilityof Vitamin E nanoemulsions | 第36-67页 |
| ·Introduction | 第36-39页 |
| ·Materials and methods | 第39-43页 |
| ·Nanoemulsions preparation | 第40页 |
| ·Particle size characterization,PDI and ζ-potential | 第40页 |
| ·Determination of the critical micelle concentration(CMC)of MSs by Surface Tension | 第40页 |
| ·Shear viscosity measurements | 第40-41页 |
| ·Interfacial tension | 第41页 |
| ·Experimental design and statistical analysis | 第41-42页 |
| ·DOE of VE loaded NE system | 第42-43页 |
| ·Results and Discussion | 第43-58页 |
| ·Design of experiments | 第43-44页 |
| ·Effect of high-pressure homogenization on the particle size of VE nanoemulsions | 第44-45页 |
| ·Effect of physicochemical properties and molecular characteristics of MSs on formation of micelles | 第45-46页 |
| ·Effect of type of emulsifier on VE nanoemulsion droplet diameter | 第46-51页 |
| ·Effect of physicochemical properties and molecular characteristics of MSs on nanoemulsions mean particle diameter | 第51-53页 |
| ·Effect of VE to MCT ratio in oil phase on VE nanoemulsions droplet diameter | 第53-55页 |
| ·Influence of interfacial characteristics of emulsifier on the formation of VE nanoemulsion | 第55-56页 |
| ·Influence of environmental stresses on the stability of VE nanoemulsion formed by high energy homogenization | 第56-58页 |
| ·Conclusion | 第58-60页 |
| Rerferences | 第60-67页 |
| Chapter 3: Low Energy Emulsification:Effect of environmental stress and long-termstorage on stability and degradation of Vitamin E nanoemulsions | 第67-93页 |
| ·Introduction | 第67-68页 |
| ·Materials and methods | 第68-71页 |
| ·Materials | 第68-69页 |
| ·Nanoemulsion formation | 第69页 |
| ·Rheology measurements | 第69页 |
| ·Mean droplet diameter,polydispersity index and ζ-potential measurements | 第69页 |
| ·Environmental stresses | 第69-70页 |
| ·Quantification of Vitamin E in nanoemulsions | 第70页 |
| ·Storage stability | 第70页 |
| ·Statistical analysis | 第70-71页 |
| ·Results and Discussion | 第71-87页 |
| ·Effect of OSA modified starches on nanoemulsions particle size produced by Low energy emulsification method | 第71页 |
| ·Formation and microstructure of nanoemulsions formed with the EPI method | 第71-73页 |
| ·Effect of the composition of the oil phase and surfactant on the formation and properties of the nanoemulsion | 第73页 |
| ·Effect of the ratio of surfactant to oil on the droplet size | 第73-75页 |
| ·Influence of oil type on mean droplet diameter | 第75-77页 |
| ·Influence of oil phase viscosity on mean droplet diameter | 第77-78页 |
| ·Effect of environmental stresses on nanoemulsion's mean droplet diameter and stabilty | 第78页 |
| ·Influence of heat treatment | 第78-81页 |
| ·Effect of pH and salts contents on mean droplet diameter and stability | 第81-83页 |
| ·Effect of long term storage on mean droplet diameter and stability | 第83-87页 |
| ·Effect of homogenization method on particle size and stability | 第87页 |
| ·Conclusion | 第87-89页 |
| References | 第89-93页 |
| Chapter 4: Effect of physicochemical properties of wall material on retention andstability of Vitamin E by spray-drying technique | 第93-116页 |
| ·Introduction | 第93-94页 |
| ·Material and Methods | 第94-97页 |
| ·OSA modified Starches characterization | 第94-95页 |
| ·Interfacial tension | 第95页 |
| ·Preparation of VE nanoemulsions | 第95-96页 |
| ·Spray-drying process | 第96页 |
| ·Nanocapsules characterization | 第96页 |
| ·Original and Reconstituted nanoemulsions characterization | 第96-97页 |
| ·Experimental design and statistical analysis | 第97页 |
| ·Results and Discussion | 第97-111页 |
| ·Properties of Modified starches | 第97-102页 |
| ·Nanoemulsions characterization | 第102-104页 |
| ·VE retention and its degradation kinetics in nanocapsules | 第104-108页 |
| ·Thermal analysis | 第108-109页 |
| ·Nanocapsules morphology | 第109-111页 |
| ·Conclusion | 第111-112页 |
| References | 第112-116页 |
| Chapter 5: Role of physicochemical properties of modified starches as stabilizers ofNanoemulsions on Vitamin E bioaccessibility | 第116-131页 |
| ·Introduction | 第116-117页 |
| ·Mate rial and Methods | 第117-120页 |
| ·Preparation of Vitamin E nanoemulsions | 第118页 |
| ·Particle size characterization,polydispersity(PDI)and ζ-potential | 第118页 |
| ·Quantification of VE in digesta by HPLC | 第118页 |
| ·In vitro modified starch digestibility | 第118-119页 |
| ·Simulated gastrointestinal tract model | 第119-120页 |
| ·Vitamin E bioaccessibility | 第120页 |
| ·Experimental design and statistical analysis | 第120页 |
| ·Results and discussions | 第120-127页 |
| ·In vitro digestibility of OSA-Modified starch | 第121-122页 |
| ·Influence of physicochemical properties and molecular characteristics of MSs on particle size,FFAs release and bioaccessibility | 第122-126页 |
| ·Effect of homogenization method on behaviour of nanoemulsions | 第126-127页 |
| ·Conclusion | 第127-128页 |
| References | 第128-131页 |
| Chapter 6: General Conclusion and Recommendations | 第131-134页 |
| ·Conclusion | 第131-132页 |
| ·Recommendations | 第132-133页 |
| References | 第133-134页 |
| Key innovations | 第134-135页 |
| List of publications | 第135页 |
