| Acknowledgements | 第5-6页 |
| Abstract | 第6-8页 |
| 摘要 | 第9-16页 |
| Chapter 1 Literature review | 第16-72页 |
| 1.1 Introduction | 第16-17页 |
| 1.2 Synthesis of polyphosphazenes | 第17-19页 |
| 1.2.1 Thermal ring opening polymerization | 第18页 |
| 1.2.2 Living cationic polymerization | 第18-19页 |
| 1.3 Types of linkages in polyphosphazenes | 第19-32页 |
| 1.3.1 Nitrogen linked groups | 第22-27页 |
| 1.3.1.1 Nitrogen linked esters | 第22-24页 |
| 1.3.1.2 Nitrogen linked ether | 第24-25页 |
| 1.3.1.3 Nitrogen linked aromatic compounds | 第25-27页 |
| 1.3.2 Oxygen linked substituents | 第27-30页 |
| 1.3.2.1 Oxygen linked esters | 第27-28页 |
| 1.3.2.2 Oxygen linked ethers | 第28页 |
| 1.3.2.3 Oxygen linked aromatic compounds | 第28-30页 |
| 1.3.3 Nitrogen and oxygen linked groups on same phosphorous atom | 第30-32页 |
| 1.4 Different approaches for drug delivery | 第32-53页 |
| 1.4.1 Polyphosphazene-drug conjugate | 第34-36页 |
| 1.4.2 Polyphosphazene hydrogels | 第36-41页 |
| 1.4.3 Polyphosphazene microspheres | 第41-42页 |
| 1.4.4 Co-polymeric micelles of polyphosphazene | 第42-47页 |
| 1.4.5 Polyphosphazene blends with other polymers | 第47-53页 |
| 1.5 Polyphosphazenes towards clinical development | 第53-54页 |
| 1.6 Research objectives | 第54-56页 |
| References | 第56-72页 |
| Chapter 2 Synthesis of polyphosphazene with methyl-4-hydroxy benzoate, 4-hydroxy benzaldehyde and diethylamine side groups and preparation of fibers andfilms based on its blends with PVP for controlled delivery of anti-cancer drug | 第72-96页 |
| 2.1 Introduction | 第72-74页 |
| 2.2 Experimental | 第74-78页 |
| 2.2.1 Materials and equipment | 第74-75页 |
| 2.2.2 Synthesis of poly[(methyl-4-hydroxybenzoate) (4-hydroxy benzaldehyde)(diethylamino) phosphazene] (PMHTP) | 第75页 |
| 2.2.3 Blend preparation | 第75-76页 |
| 2.2.4 Fabrication of fibers without and with drug | 第76页 |
| 2.2.5 Preparation of drug loaded films | 第76-77页 |
| 2.2.6 Hydrolytic degradation | 第77页 |
| 2.2.7 In vitro drug release | 第77-78页 |
| 2.3 Results and discussion | 第78-89页 |
| 2.3.1 Synthesis and characterization of PMHTP | 第78-80页 |
| 2.3.2 Blending of PMHTP and PVP | 第80-81页 |
| 2.3.3 Thermal properties of PMHTP and P3B3-3 | 第81-82页 |
| 2.3.4 Hydrolytic degradation | 第82-85页 |
| 2.3.5 Preparation of fibers | 第85页 |
| 2.3.6 Preparation of drug loaded films | 第85页 |
| 2.3.7 Drug release studies | 第85-89页 |
| 2.4 Conclusion | 第89-90页 |
| References | 第90-96页 |
| Chapter 3 Synthesis of polyphosphazenes with acetamidophenol and glycine methylester side groups and preparation of microsphere from polyphosphazene blends withPMMA for drug combination therapy | 第96-130页 |
| 3.1 Introduction | 第96-98页 |
| 3.2 Experimental | 第98-104页 |
| 3.2.1 Materials and equipments | 第98页 |
| 3.2.2 Synthesis of polyphosphazenes | 第98-100页 |
| 3.2.3 Preparation of microspheres from polyphosphazene blend with PMMA | 第100-102页 |
| 3.2.4 Hydrolytic degradation studies | 第102页 |
| 3.2.5 Loading of CPT in blend microspheres | 第102-103页 |
| 3.2.6 Drug release studies | 第103-104页 |
| 3.3 Results and discussions | 第104-122页 |
| 3.3.1 Synthesis and characterization of polyphosphazenes | 第104-110页 |
| 3.3.2 Preparation of microspheres from blends of polyphosphazene and PMMA | 第110-111页 |
| 3.3.3 Hydrolytic degradation of microspheres | 第111-112页 |
| 3.3.4 Preparation of double drug loaded blend microspheres | 第112-120页 |
| 3.3.5 Drug release studies of CPT and AMP | 第120-122页 |
| 3.4 Conclusion | 第122-123页 |
| References | 第123-130页 |
| Chapter 4 Synthesis of polyphosphazenes with aminoazotoluene and methoxypolyethylene glycol side groups and preparation of UV and pH responsivenanostructures for drug delivery | 第130-160页 |
| 4.1 Introduction | 第130-132页 |
| 4.2 Materials and methods | 第132-136页 |
| 4.2.1 Materials and equipment | 第132页 |
| 4.2.2 Synthesis of polyphosphazenes | 第132-133页 |
| 4.2.3 Hydrolytic degradation | 第133-134页 |
| 4.2.4 UV-Visible response of SUM-401,SUM-402 and SUM-404 | 第134页 |
| 4.2.5 Preparation of different nanostructures | 第134-135页 |
| 4.2.6 Drug release studies | 第135-136页 |
| 4.3 Results and discussions | 第136-151页 |
| 4.3.1 Synthesis of polyphosphazenes | 第136-142页 |
| 4.3.2 Hydrolytic degradation studies | 第142-144页 |
| 4.3.3 UV-Visible response of polyphosphazenes | 第144页 |
| 4.3.4 Preparation of different nanostructures by self-assembly | 第144-147页 |
| 4.3.5 Drug release studies | 第147-151页 |
| 4.4 Conclusion | 第151页 |
| References | 第151-160页 |
| Chapter 5 Synthesis of polyphosphazenes with 4-hydroxybenzaldehyde and glycineethyl ester side groups and preparation of microspheres for the delivery of5 -Fluorouracil | 第160-178页 |
| 5.1 Introduction | 第160-161页 |
| 5.2 Materials and methods | 第161-163页 |
| 5.2.1 Synthesis of polyphosphazenes | 第161-162页 |
| 5.2.2 Preparation of microspheres | 第162-163页 |
| 5.2.3 Drug release studies of 5-FU from microspheres | 第163页 |
| 5.3 Results and discussion | 第163-173页 |
| 5.3.1 Synthesis of polyphosphazene | 第163-165页 |
| 5.3.2 Preparation of microspheres | 第165-169页 |
| 5.3.3 Drug release studies of microspheres | 第169-173页 |
| 5.4 Conclusion | 第173页 |
| References | 第173-178页 |
| Chapter 6 Conclusion | 第178-181页 |
| List of abbreviations | 第181-183页 |
| Curriculum vitae | 第183-184页 |
