| 摘要 | 第7-10页 |
| ABSTRACT | 第10-14页 |
| ABBREVIATIONS | 第15-18页 |
| CHAPTER 1 REVIEW OF LITERATURE | 第18-57页 |
| 1.1 Introduction of blunt snout bream | 第18-29页 |
| 1.1.1 Biological characteristics | 第18-19页 |
| 1.1.2 Situation of high fat and high carbohydrate used in feed industry | 第19-24页 |
| 1.1.3 Important to research | 第24-29页 |
| 1.2 Metabolomics study | 第29-42页 |
| 1.2.1 What is metabolomics? | 第29-32页 |
| 1.2.2 Advantage of metabolomics compared with other technology | 第32-39页 |
| 1.2.3 Applications of metabolomics | 第39-42页 |
| 1.3 Fat diet and its metabolism in fish | 第42-50页 |
| 1.3.1 Fat characteristics | 第42-44页 |
| 1.3.2 Function in animals | 第44-46页 |
| 1.3.3 Pathway and impact factors of lipid metabolism | 第46-50页 |
| 1.4 Carbohydrate diet and its metabolism in fish | 第50-57页 |
| 1.4.1 Carbohydrate characteristics | 第50-51页 |
| 1.4.2 Function in animals | 第51-52页 |
| 1.4.3 Pathway and impact factors of carbohydrate metabolism | 第52-57页 |
| CHAPTER 2 METABOLIC ALTERATIONS AFFECTED BY HIGH FAT DIET | 第57-73页 |
| 2.1 Introduction | 第57-58页 |
| 2.2 Materials and methods | 第58-64页 |
| 2.2.1 Fish and samples for experiment | 第58-59页 |
| 2.2.2 Serum biochemical analysis | 第59-60页 |
| 2.2.3 Metabolomics study by NMR | 第60-64页 |
| 2.3 Results | 第64-70页 |
| 2.3.1 Serum biochemical alterations affected by high fat diet | 第64-65页 |
| 2.3.2 Metabolic alterations affected by high fat diet | 第65-70页 |
| 2.4 Discussions | 第70-73页 |
| 2.4.1 Serum biochemical alterations affected by high fat diet | 第70-71页 |
| 2.4.2 Metabolic alterations affected by high fat diet | 第71-73页 |
| CHAPTER 3 METABOLIC ALTERATIONS AFFECTED BY HIGH CARBOHYDRATE DIET | 第73-87页 |
| 3.1 Introduction | 第73-74页 |
| 3.2 Materials and methods | 第74-75页 |
| 3.2.1 Fish and samples for experiment | 第74页 |
| 3.2.2 Serum biochemical analysis | 第74页 |
| 3.2.3 Metabolomics study by NMR | 第74-75页 |
| 3.3 Results | 第75-80页 |
| 3.3.1 Serum biochemical alterations affected by high carbohydrate diet | 第75-76页 |
| 3.3.2 Metabolic alterations affected by high carbohydrate diet | 第76-80页 |
| 3.4 Discussion | 第80-87页 |
| 3.4.1 Serum biochemical alterations affected by high carbohydrate diet | 第80-81页 |
| 3.4.2 Metabolic alterations affected by high carbohydrate diet | 第81-87页 |
| CHAPTER 4 METABOLIC ALTERATIONS AFFECTED BY HIGH-FAT HIGH- CARBOHYDRATE DIET | 第87-98页 |
| 4.1 Introduction | 第87-88页 |
| 4.2 Materials and methods | 第88-89页 |
| 4.2.1 Fish and samples for experiment | 第88页 |
| 4.2.2 Serum biochemical analysis | 第88-89页 |
| 4.2.3 Metabolomics study by NMR | 第89页 |
| 4.3 Results | 第89-94页 |
| 4.3.1 Serum biochemical alterations affected by high-fat high- carbohydrate diet | 第89-90页 |
| 4.3.2 Metabolic alterations affected by high-fat high- carbohydrate diet | 第90-94页 |
| 4.4 Discussions | 第94-98页 |
| 4.4.1 Serum biochemical alterations affected by high-fat high- carbohydrate diet | 第94-95页 |
| 4.4.2 Metabolic alterations affected by high-fat high- carbohydrate diet | 第95-98页 |
| CHAPTER 5 PAIRWISE GROUP COMPARISON OF METABOLOMICS STUDY | 第98-123页 |
| 5.1 Introduction | 第98-99页 |
| 5.2 Materials and methods | 第99-100页 |
| 5.2.1 Metabolic alterations affected by high carbohydrate compared with high fatdiet | 第99页 |
| 5.2.2 Metabolic alterations affected by high-fat high- carbohydrate diet comparedwith high fat diet | 第99-100页 |
| 5.2.3 Metabolic alterations affected by high-fat high- carbohydrate diet comparedwith high carbohydrate diet | 第100页 |
| 5.3 Results | 第100-109页 |
| 5.3.1 Metabolic alterations affected by high carbohydrate compared with high fatdiet | 第100-103页 |
| 5.3.2 Metabolic alterations affected by high-fat high- carbohydrate diet comparedwith high fat diet | 第103-106页 |
| 5.3.3 Metabolic alterations affected by high-fat high- carbohydrate diet comparedwith high carbohydrate diet | 第106-109页 |
| 5.4 Discussion | 第109-123页 |
| 5.4.1 Metabolic alterations affected by high carbohydrate compared with high fatdiet | 第109-112页 |
| 5.4.2 Metabolic alterations affected by high-fat high- carbohydrate diet comparedwith high fat diet | 第112-117页 |
| 5.4.3 Metabolic alterations affected by high-fat high- carbohydrate diet comparedwith high carbohydrate diet | 第117-123页 |
| CHAPTER 6 CONCLUSIONS | 第123-125页 |
| REFERENCES | 第125-152页 |
| APPENDIX 1 METABOLOMICS PROFILE OF MEGALOBRAMA AMBLYCEPHALA BY USINGMETABOLOMICS | 第152-159页 |
| APPENDIX 2 PUBLICATIONS | 第159页 |
| APPENDIX 3 AWARDS AND FUNDING | 第159-160页 |
| ACKNOWLEDGEMENTS | 第160-162页 |
