| Abstract | 第5-7页 |
| 中文摘要 | 第8-11页 |
| Abbreviations | 第11-13页 |
| Chapter Ⅰ: A Brief Review VEGF and Receptors in angiogenesis and lymphangiogenesis | 第13-51页 |
| 1. Development and function of the blood and lymphatic vasculature | 第14-26页 |
| 1.1 The blood vascular system | 第14-21页 |
| 1.1.1 Vasculogenesis and hematopoiesis | 第14-16页 |
| 1.1.2 Angiogenesis | 第16-21页 |
| 1.1.2.1 Early embryo angiogenesis | 第16-18页 |
| 1.1.2.2 Postnatal Retinal Angiogenesis | 第18-20页 |
| 1.1.2.3 Tumor angiogenesis | 第20-21页 |
| 1.2 The lymphatic vascular system | 第21-26页 |
| 1.2.1 Commitment to lymphatic endothelial cell fate | 第22-24页 |
| 1.2.2 Disconnection from the vein | 第24-25页 |
| 1.2.3 Expansion and remodeling of primitive lymphatic vessels | 第25-26页 |
| 2. VEGF and VEGF Receptors in angiogenesis and lymphangiogenesis | 第26-41页 |
| 2.1 The VEGF and VEGFR family | 第26-28页 |
| 2.2 VEGF and VEGFR-2: Signaling for angiogenesis | 第28-32页 |
| 2.3 PIGF, VEGF-B and VEGFR-1: The angiogenic modifiers | 第32-33页 |
| 2.4 VEGF-C, VEGF-D and VEGFR-3: Signaling for lymphangiogenesis | 第33-37页 |
| 2.5 VEGF-C/VEGFR-3 signaling for angiogenesis: a paradox | 第37-41页 |
| References | 第41-51页 |
| Chapter Ⅱ: VEGF-R3 signaling is important for lymphangiogenesis but isnot required for angiogenesis | 第51-78页 |
| Summary | 第52页 |
| Introduction | 第52-54页 |
| Materials and methods | 第54-56页 |
| Results | 第56-72页 |
| Generation of mice expressing VEGFR-3~(△LBD) | 第56-61页 |
| Blood vascular network forms normally in mice expressing VEGFR-3~(△LBD) | 第61-64页 |
| Lymph sac forms but lymphangiogenic sprouting is disrupted in Vegfr3~(△LBD/△LBD) | 第64-65页 |
| Blood vessels develop normally in mice lack of VEGFR-3 kinase activity | 第65-72页 |
| Discussions | 第72-75页 |
| References | 第75-78页 |
| Chapter Ⅲ:VEGF-R3 negatively regulate VEGFR-2 signaling in blood endothelial cells | 第78-96页 |
| Summary | 第79-80页 |
| Introduction | 第80页 |
| Materials and methods | 第80-84页 |
| Results | 第84-91页 |
| Generation of conditional transgenic mice expressing WT VEGFR-3 | 第84-86页 |
| Overexpression of VEGFR-3 in endothelial cells disrupts embryo angiogenesisand hematopoiesis | 第86-87页 |
| VEGFR-3 regulates VEGFR-2 mediated signaling | 第87-91页 |
| Discussions | 第91-93页 |
| References | 第93-96页 |
| Acknowledgements | 第96-97页 |
| Publication | 第97-99页 |
