| 摘要 | 第5-7页 |
| Abstract | 第7-8页 |
| Acknowledgement | 第9-13页 |
| Chapter.1 Development and application of chiral spirocyclic phosphoric acids in asymmetriccatalysis | 第13-75页 |
| 1.1 Introduction | 第13-16页 |
| 1.2 Synthesis of SPAs | 第16-17页 |
| 1.3 SPAs in asymmetric catalysis | 第17-64页 |
| 1.3.1 Friedel- Crafts reactions | 第17-24页 |
| 1.3.2 Fischer indole reaction | 第24-27页 |
| 1.3.3 Cycloaddition Reaction | 第27-33页 |
| 1.3.4 Insertion reactions | 第33-37页 |
| 1.3.5 Desymmetrization reactions | 第37-42页 |
| 1.3.6 Dearomatization reaction | 第42-45页 |
| 1.3.7 Multi-Component reaction | 第45-49页 |
| 1.3.8 Pictet-Spengler reaction | 第49-53页 |
| 1.3.9 Conjugated addition reactions | 第53-57页 |
| 1.3.10 Miscellaneous reactions | 第57-64页 |
| 1.4 Conclusion and outlook | 第64-66页 |
| 1.5 References | 第66-75页 |
| Chapter.2 Organocatalytic asymmetric synthesis of benzazepinoindole derivatives withtrifluoromethylated quaternary stereocenters by chiral phosphoric acid catalysis | 第75-105页 |
| 2.1 Introduction | 第75-76页 |
| 2.2 Synthesis of trifluoromethyl dihydrobenzoazepinoindoles | 第76-77页 |
| 2.3 Optimization of reaction conditions | 第77-79页 |
| 2.4 Scope of trifluoromethyl dihydrobenzoazepinoindoles with pyrroles | 第79-81页 |
| 2.5 Scope of trifluoromethyl dihydrobenzoazepinoindoles with indoles | 第81-82页 |
| 2.6 Plausible mechanism for aza-Friedel-Craft reaction | 第82-83页 |
| 2.7 Conclusion | 第83页 |
| 2.8 Experimental section | 第83-98页 |
| 2.8.1 Reagent and instruments | 第83页 |
| 2.8.2 General procedure for the Enantioselective aza-Friedel-Crafts Reaction with pyrroles orindoles | 第83-84页 |
| 2.8.3 Characterization of compounds | 第84-98页 |
| 2.9 Refernces | 第98-105页 |
| Chapter.3 Organocatalyzed Asymmetric 1,6-Addition Reaction for theConstruction of Unprotected 3,3'-Disubstituted Oxindole Containing Quaternary Stereogeniccenter | 第105-127页 |
| 3.1 Introduction | 第105-106页 |
| 3.2 Optimization of reaction conditions | 第106-108页 |
| 3.3 Scope of oxindolo-methoids and indole | 第108-110页 |
| 3.4 Reaction of oxindolo-methoids with pyrrole | 第110-111页 |
| 3.5 Non-linear effect | 第111-112页 |
| 3.6 Graphical Representation | 第112页 |
| 3.7 Experimental section | 第112-124页 |
| 3.7.1 Chemical and reagent | 第112页 |
| 3.7.2 Procedure for the synthesis of Oxindole methoids | 第112-113页 |
| 3.7.3 Procedure for the Asymmetric 1,6-Addition Reaction for theConstruction of Unprotected3,3-Disubstituted Oxindoles | 第113页 |
| 3.7.4 Characterization of compounds | 第113-124页 |
| 3.8 References | 第124-127页 |
| Chapter.4 Asymmetric transfer hydrogenation of seven member cyclic aldimines catalyzed bychiral phosphoric acids | 第127-147页 |
| 4.1 Introduction | 第127-128页 |
| 4.2 Synthesis of substrates 4.1 | 第128-130页 |
| 4.2.1 General procedure for the synthesis of substrate dibenzoazepines | 第129-130页 |
| 4.3 Optimization reaction conditions for catalytic transfer hydrogenation | 第130-134页 |
| 4.3.1 Screening of catalysts and additives | 第130-131页 |
| 4.3.2 Screening of solvent and tempreture | 第131-134页 |
| 4.4 Conclusion | 第134页 |
| 4.5 Experimental section | 第134-135页 |
| 4.5.1 Chemical and reagents | 第134-135页 |
| 4.5.2 General procedure for the synthesis of dibezoazepines | 第135页 |
| 4.6 Characterization of compounds | 第135-145页 |
| 4.7 References | 第145-147页 |
| 附录 | 第147-226页 |
| Publication | 第226页 |
