| LIST OF ABBREVIATION | 第1-9页 |
| Chapter 1 Effect of ethanol on spontaneous complex spike activity of cerebellar Purkinjecell in vivo in mice | 第9-40页 |
| Abstract | 第10-12页 |
| 摘要 | 第12-14页 |
| ·Introduction | 第14-17页 |
| ·Materials and Methods | 第17-19页 |
| ·Anesthesia and surgical procedures | 第17页 |
| ·Electrophysiological recording and drug application | 第17-18页 |
| ·Histochemistry | 第18页 |
| ·Chemicals | 第18页 |
| ·Data analysis | 第18-19页 |
| ·Results | 第19-28页 |
| ·Ethanol inhibited the waveform of spontaneous complex spikes (CS) ofcerebellar PCs | 第19-22页 |
| ·Blockade of mGluRl and NMDA receptors failed to prevented theethanol-induced inhibition of CS activity | 第22-23页 |
| ·Ethanol-induced depression of CS waveform was abolished by blockingCB1 receptors activity | 第23-28页 |
| ·Discussion | 第28-32页 |
| ·Ethanol modulates the spontaneous CS firing of cerebellar PCs | 第28-30页 |
| ·Activation of CB1 receptors induces an inhibition in synaptic transmitterrelease at CF-PC synapses | 第30-31页 |
| ·Ethanol modulates the spontaneous CS firing of cerebellar PCs viaactivation of CB1 receptors activity | 第31-32页 |
| Acknowledgements | 第32-33页 |
| References | 第33-40页 |
| Chapter 2 Mechanism of ethanol modulation of the facial stimulation-evoked outwardcurrents of cerebellar Purkinje cell in vivo in mice | 第40-69页 |
| Abstract | 第41-43页 |
| 摘要 | 第43-45页 |
| ·Introduction | 第45-47页 |
| ·Materials and Methods | 第47-49页 |
| ·Anesthesia and surgical procedures | 第47页 |
| ·Electrophysiological recording and facial stimulation | 第47-48页 |
| ·Chemicals | 第48-49页 |
| ·Data analysis | 第49页 |
| ·Results | 第49-57页 |
| ·Ethanol inhibited the facial stimulation-evoked outward currents incerebellar PCs | 第49-53页 |
| ·Ethanol-induced inhibition of facial stimulation-evoked inward currentswas involved in activation of CB1 receptor | 第53-57页 |
| ·Discussion | 第57-62页 |
| ·Facial stimulation excites MLIs and evokes outward currents in cerebellarPCs | 第57-59页 |
| ·Ethanol inhibits facial stimulation evoked MLI-PC GABAergic synaptictransmission in cerebellar PCs | 第59-60页 |
| ·Ethanol inhibits facial stimulation evoked outward currents in cerebellarPCs via activation of eCB system | 第60-62页 |
| Acknowledgements | 第62-63页 |
| References | 第63-69页 |
| Review Effects of ethanol on neurotransmitter system in central nervous system | 第69-95页 |
| References | 第82-95页 |
| Publications | 第95-96页 |
| 致谢 | 第96页 |
