| 中文摘要 | 第3-7页 |
| ABSTRACT | 第7-8页 |
| Chapter1 Introduction | 第11-25页 |
| 1.1 Photothmal therapy | 第12-16页 |
| 1.1.1 Introduction of the photothermal therapy | 第12页 |
| 1.1.2 Common photothermal agents | 第12-16页 |
| 1.2 Photodynamic therapy | 第16-19页 |
| 1.2.1 Introduction of photodynamic therapy | 第16-17页 |
| 1.2.2 The mechanism of photodynamic therapy | 第17-18页 |
| 1.2.3 The photosensitizers of photodynamic therapy | 第18页 |
| 1.2.4 The functional nanomaterials of photodynamic therapy | 第18-19页 |
| 1.3 Different model imaging technologies of cancer therapy | 第19-22页 |
| 1.3.1 Conventional single-modality imaging | 第19-22页 |
| 1.3.2 Multi-modality imaging | 第22页 |
| 1.4 Project design | 第22-25页 |
| Chapter2 TD-controlled and ICG-loaded CuS@mSiO_2 for fluorescence/PA dual-imaging guided synergistic PTT/PDT cancer therapy | 第25-55页 |
| 2.1 Brief introduction | 第25-27页 |
| 2.2 Materials and methods | 第27-38页 |
| 2.2.1 Experimentalmaterials and equipments | 第27-29页 |
| 2.2.2 Preparation and characterization of CuS@mSiO_2 | 第29-31页 |
| 2.2.3 Preparation and characterization of CuS@mSiO_2-TD/ICG | 第31-33页 |
| 2.2.4 Cell culture and cellular studies | 第33-36页 |
| 2.2.5 In vivo animal experiments | 第36-38页 |
| 2.3 Results and discussion | 第38-54页 |
| 2.3.1 Preparation and characterization of CuS@mSiO_2 | 第38-41页 |
| 2.3.2 Drug loadingand characterization of CuS@mSiO_2-TD/ICG | 第41-46页 |
| 2.3.3 Cellular studies | 第46-49页 |
| 2.3.4 In vivo animal studies | 第49-54页 |
| 2.4 Brief summary | 第54-55页 |
| Chapter3 BSA-bioinspired gadolinium hybrid-functionalized hollow gold nanoshells for fluorescence/PA/CT/MR quad-modal imaging guided PTT/PDT cancer therapy | 第55-93页 |
| 3.1 Brief introduction | 第55-57页 |
| 3.2 Materials and methods | 第57-69页 |
| 3.2.1 Experimentalmaterials and equipments | 第57-60页 |
| 3.2.2 Preparation and characterization of Au@BSA-Gd | 第60-63页 |
| 3.2.3 ICG loading and characterization of ICG-Au@BSA-Gd | 第63-65页 |
| 3.2.4 Cell culture and cellular studies | 第65-67页 |
| 3.2.5 In vivo animal experiments | 第67-69页 |
| 3.3 Results and discussion | 第69-91页 |
| 3.3.1 Preparation and Characterization of HAuNs | 第69-72页 |
| 3.3.2 Preparation and Characterizationof Au@BSA-Gd | 第72-75页 |
| 3.3.3 Preparation and Characterizationof ICG-Au@BSA-Gd | 第75-81页 |
| 3.3.4 Cell culture and cellular studies | 第81-85页 |
| 3.3.5 In vivo animal studies | 第85-91页 |
| 3.4 Brief summary | 第91-93页 |
| Chapter4 Conclusion and prospect | 第93-95页 |
| 4.1 Conclusion | 第93-94页 |
| 4.2 Prospect | 第94-95页 |
| References | 第95-109页 |
| Notes on publications and participation in scientific research | 第109-111页 |
| Acknowledgement | 第111页 |
