| 摘要 | 第1-7页 |
| Abstract | 第7-19页 |
| Part Ⅰ Introduction | 第19-36页 |
| ·Genetics | 第19-20页 |
| ·Neurodevelopment and the sexual differentiation of the brain | 第20-23页 |
| ·Prenatal hormone | 第20-21页 |
| ·Sexual dimorphisms in the adult brain | 第21-23页 |
| ·Homone, receptors and neurotransmitter correlates of animals sexual orientation | 第23-28页 |
| ·Estrogen, Estrogen receptor α (ERα) and β (ERβ) | 第23-24页 |
| ·Androgen and androgen receptor (AR) | 第24-26页 |
| ·Vasopressin (AVP), Oxytocin (OT) | 第26-28页 |
| ·Behavioral difference between individuals with heterosexual and homosexual orientation | 第28-30页 |
| ·Spatial memory | 第28-29页 |
| ·Depression and anxiety | 第29-30页 |
| ·Social interaction behaviors | 第30页 |
| ·Mandarin vole (Microtus ochrogaster) | 第30-31页 |
| ·Basic for topic selection | 第31-32页 |
| ·Research significance and content | 第32-36页 |
| ·Significance of the study | 第32-34页 |
| ·Contents of the study | 第34-36页 |
| Part Ⅱ Materials and methods | 第36-45页 |
| ·Materials | 第36-38页 |
| ·Animals | 第36页 |
| ·Treatment procedure | 第36-38页 |
| ·Behavioral tests | 第38-42页 |
| ·Female and male sexual orientation tests | 第38-39页 |
| ·Open-field test (OF) | 第39页 |
| ·Tail suspension test (TST) | 第39-40页 |
| ·Morris water maze test | 第40页 |
| ·Social interactions test | 第40-42页 |
| ·Serum T and E_2 measurement | 第42页 |
| ·Double immunohistochemistry | 第42-43页 |
| ·Statistical analysis | 第43-45页 |
| ·Behavioral data analysis | 第43-44页 |
| ·Serum T and E_2 data analysis | 第44页 |
| ·Immunohistochemistry data analysis | 第44-45页 |
| Part Ⅲ Results | 第45-88页 |
| ·Behavioral results | 第45-67页 |
| ·Effect of estrogen on female sexual orientation | 第45-48页 |
| ·Effect of clomiphene citrate on male sexual orientation | 第48-52页 |
| ·Effect of estrogen or clomiphene citrate treatment on behaviors in the OF test | 第52-54页 |
| ·Effect of estrogen or clomiphene citrate treatment on performance in TST test | 第54-55页 |
| ·Effect of estrogen or clomiphene citrate treatment on performance in Morris water maze | 第55-67页 |
| ·Changes in serum T and E_2 concentrations after social interaction | 第67-70页 |
| ·Changes in serum T and E_2 concentrations of female treatment groups after social interaction | 第67-68页 |
| ·Changes in serum T and E_2 concentrations of male treatment groups after social interaction | 第68-70页 |
| ·ERα, ERβ and OT immunoreactivity in brain areas of the females withhomosexual and heterosexual orientation | 第70-74页 |
| ·ERα in the AHA, mPOA, BNST, MeA in the animals from FC, FT1 and FT2 groups | 第70-71页 |
| ·ERβ in the AHA, mPOA, BNST, MeA in the animals from FC, FT1 and FT2 groups | 第71-72页 |
| ·ERa,ERβ, OT, OT/ERα and OT/ERβ dual-labeled cells in the PVN and SON in the animals from FC, FT1 and FT2 groups | 第72-74页 |
| ·AR and AVP immunoreactivity in brain areas of the male with homosexual andheterosexual orientation | 第74-77页 |
| ·AR in the AHA, mPOA, BNST and MeA in the animals from MC, MT1 and MT2 groups | 第74-75页 |
| ·AR, AVP and AVP/AR dual-labeled cells in the PVN and SON in the animals from MC, MT1 and MT2 groups | 第75-77页 |
| ·ERβ immunoreactivity in hippocampus of the male and female with homosexualand heterosexual orientation | 第77-78页 |
| ·Fos and AVP/Fos dual-labeled cells in the subject animals from FC, FT1 and FT2 groups after social interaction | 第78-81页 |
| ·Fos and OT/Fos dual-labeled cells in the subject animals from FC, FT1 and FT2 groups after social interaction | 第81-83页 |
| ·Fos and AVP/Fos dual-labeled cells in the subject animals from MC, MT1 and MT groups after social interaction | 第83-86页 |
| ·Fos and OT/Fos dual-labeled cells in the subject animals from MC, MT1 and MT groups after social interaction | 第86-88页 |
| Part Ⅳ Disscussion | 第88-118页 |
| ·Estrogen treatment during development altered female sexual orientation | 第88-89页 |
| ·ERα in the AHA, mPOA, BNST and MeA in female with different sexual orientation | 第89-92页 |
| ·Effects of ERβ in the AHA, mPOA, BNST and MeA on female sexual orientation and behaviors | 第92-93页 |
| ·Co-location of ERα, ERβ and OT in brain regions of individuals with different sexual orientation | 第93-95页 |
| ·Clomiphene citrate treatment during development alters adult male sex orientation | 第95-96页 |
| ·Effects of AR in the AHA, mPOA, BNST and MeA on male sexual orientation and behaviors | 第96-98页 |
| ·Association of AR and AVP in the PVN and SON with male sexual orientation and behaviors | 第98-99页 |
| ·Prenatal and postnatal estrogen treatment might be related to anxiety and depression of female vole | 第99-101页 |
| ·Prenatal and postnatal clomiphene citrate salt treatment might be related to anxiety and depression of male vole | 第101-102页 |
| ·Sexual differences in spatial learning and memory | 第102-105页 |
| ·Sexual orientation affected spatial memory | 第105-106页 |
| ·Serum E_2 and T in female vole with different sexual orientation of following social interaction | 第106-108页 |
| ·The expression of Fos-IRs in female vole with homosexual or heterosexual orientation during social interaction | 第108-109页 |
| ·The expression of AVP-IRs, OT-IRs, AVP/Fos and OT/Fos dual-labeled cells in female vole with homosexual or heterosexual orientation following social interaction | 第109-111页 |
| ·Serum E_2 and T in male vole with different sexual orientation of and following social interaction | 第111-113页 |
| ·The expression of Fos-IRs in male vole with homosexual or heterosexual orientation during social interaction | 第113-115页 |
| ·The expression of OT-IRs, AVP-IRs, AVP/Fos and OT/Fos dual-labeled cells in male vole with homosexual and heterosexual orientation during social interaction | 第115-116页 |
| ·The problems and prospects | 第116-118页 |
| Conclusions and innovations | 第118-121页 |
| Plates | 第121-129页 |
| Reference | 第129-156页 |
| 致谢 | 第156-157页 |
| List of publications | 第157-158页 |
