| CONTENTS | 第5-8页 |
| Ⅰ. LIST OF TABLES | 第8-9页 |
| Ⅱ. LIST OF FIGURES | 第9-11页 |
| Ⅲ. ABBREVIATIONS | 第11-14页 |
| Ⅳ. ABSTRACT | 第14-15页 |
| 1. INTRODUCTION | 第16-31页 |
| 1.1. Food Security | 第16-17页 |
| 1.2. Importance of Maize | 第17-19页 |
| 1.3. Requirement for Optimum Growth | 第19-20页 |
| 1.4. Level of Genetic Diversity in Maize | 第20-23页 |
| 1.5. Availability of Molecular Marker | 第23-24页 |
| 1.6. Global Losses due to Plant Diseases | 第24-30页 |
| 1.7. Goals and Objectives of this Study | 第30-31页 |
| 2. BACKGROUND | 第31-57页 |
| 2.1 The Phenomenon of Resistance in the Light of History | 第31-36页 |
| 2.2 Concept of Pathology and General Terminology Used for Disease Resistance | 第36-38页 |
| 2.2.1 Basic Concepts of Pathology | 第36页 |
| 2.2.2 Pathogenesis | 第36-37页 |
| 2.2.3 Epiphytotics | 第37-38页 |
| 2.3 Resistance and Genetic Tools to Improve Resistance | 第38-45页 |
| 2.3.1 Types of Resistance | 第38-39页 |
| 2.3.2 Non-Host and Host Resistances | 第39-41页 |
| 2.3.3 Quantitative Disease Resistance(QDR)and Multiple Disease Resistance (MDR) | 第41-45页 |
| 2.4 Need for Genetic Diversity | 第45-47页 |
| 2.5 Impact of Joint Linkage and Genome-Wide Association Mapping in Elevating Disease Resistance | 第47-48页 |
| 2.6 Molecular Breeding for Disease-Resistant Maize:Process and Challenge | 第48-50页 |
| 2.7 Meta-analysis for Foliar Diseases | 第50-53页 |
| 2.8 Genome Wide Association Mapping for Northern Leaf Blight | 第53-54页 |
| 2.9 Linkage Mapping for Southern Leaf Blight | 第54-57页 |
| 3. MATERIAL AND METHODS | 第57-66页 |
| 3.1 Collecting and Reporting QTL Data for NLB,SLB and GLS | 第57-58页 |
| 3.2 QTL Projection and Meta-Analysis for NLB,SLB and GLS QTL | 第58页 |
| 3.3 NBS-LRR Gene Family Prediction | 第58-59页 |
| 3.4 GWAS for Norhtern Leaf Blight | 第59-63页 |
| 3.4.1 Germplasm and Phenotyping | 第59-60页 |
| 3.4.2 Statistical Analyses | 第60-61页 |
| 3.4.3 Genotyping of Inbred Lines | 第61页 |
| 3.4.4 SNP Based Genome wide Association Mapping | 第61-62页 |
| 3.4.5 Haplotype based Association Studies | 第62页 |
| 3.4.6 Anderson Darling Test | 第62-63页 |
| 3.5 Southern Leaf Blight | 第63-66页 |
| 3.5.1 Plant Materials and Field Design | 第63页 |
| 3.5.2 Genotyping of the RIL | 第63-64页 |
| 3.5.3 Inoculation and Disease Assessment | 第64页 |
| 3.5.4 Linkage Map Construction and QTL Analysis | 第64-65页 |
| 3.5.5 Data Analysis | 第65-66页 |
| 4. RESULTS | 第66-91页 |
| 4.1 Disease QTL Collection | 第66-68页 |
| 4.2 Distribution of QTL on Different Chromosome | 第68-69页 |
| 4.3 Clustering and Multiple Disease Resistance QTL | 第69-71页 |
| 4.4 Meta-Analysis and Real QTL | 第71-75页 |
| 4.5 Northern Leaf Blight | 第75-87页 |
| 4.5.1 Phenotypic Diversity for NLB | 第75-76页 |
| 4.5.2 The Familial Relatedness Among the Lines | 第76-79页 |
| 4.5.3 Genetic Basis Revealed by GWAS | 第79-84页 |
| 4.5.4 Haplotype-based Association Studies | 第84-86页 |
| 4.5.5 Anderson-Darling Test for Genome Scanning | 第86-87页 |
| 4.6 Southern Leaf Blight | 第87-91页 |
| 4.6.1 Phenotypic Analysis for SLB | 第87-89页 |
| 4.6.2 Genetic linkage map and QTL analysis | 第89-91页 |
| 5. DISCUSSION | 第91-102页 |
| 5.1 Evidence of Multiple Disease Resistance | 第91-93页 |
| 5.2 Molecular Breeding for Disease Resistance and the Role of Meta-Analysis | 第93-94页 |
| 5.3 Implication of Meta-Analysis in Marker Assisted Selection(MAS) | 第94-95页 |
| 5.4 The NBS-LRR Genes in Disease Resistance | 第95-96页 |
| 5.5 Genetic Basis of Northern Leaf Blight | 第96-99页 |
| 5.5.1 Evidence of Marker Loci via A-D Test | 第99页 |
| 5.6 Genetic Basis of Southern Leaf Blight | 第99-102页 |
| 6. CONCLUSION | 第102-106页 |
| 6.1 Conclusion and Perspective | 第102-106页 |
| 7. RENCES | 第106-127页 |
| 8. APPENDICES | 第127-144页 |
| DEDICATION | 第144-146页 |
| ACKNOWLEDGEMENT | 第146-148页 |
| CURRICULUM VITEA | 第148-151页 |
