| Abstract | 第5-6页 |
| 中文摘要 | 第7-9页 |
| Abbreviations | 第9-12页 |
| Chapter Ⅰ. Review: Control of skeletal muscle mitochondrial adaptation and fiber type transformation | 第12-42页 |
| 1. Introduction of skeletal muscle mitochondria | 第13-19页 |
| 1.1 Mitochondrial adaptation: biogenesis, fusion, fission and mitophagy | 第13-15页 |
| 1.2 Mitochondrial adaptation in response to exercise | 第15-17页 |
| 1.3 Summary | 第17-19页 |
| 2. Skeletal muscle fiber type transformation | 第19-31页 |
| 2.1 Skeletal muscle fiber type specification | 第19-21页 |
| 2.2 Fiber type transformation in adult muscles | 第21-23页 |
| 2.3 Signaling pathways controlling muscle fiber type transformation | 第23-30页 |
| 2.4 Summary | 第30-31页 |
| 3. References | 第31-42页 |
| Chapter Ⅱ: Delineate the molecular mechanism controlling skeletal muscle fitness relevant to exercise | 第42-86页 |
| 1. Introduction | 第43-47页 |
| 2. Materials and Methods | 第47-54页 |
| 3. Results and Discussion | 第54-80页 |
| 3.1 Exercise inducible Ldhb regulates mitochondrial function in skeletal muscle | 第54-67页 |
| 3.1.1 Ldhb expression is regulated by exercise-induced PGC-la | 第54-57页 |
| 3.1.2 Activation of Ldhb leads to reduction of Ldha in skeletal muscle | 第57-59页 |
| 3.1.3 Enhanced exercise capacity and oxygen consumption in MCK-Ldhb mice | 第59-62页 |
| 3.1.4 Activation of Ldhb increases skeletal muscle mitochondrial oxidative capacity | 第62-66页 |
| 3.1.5 Summary | 第66-67页 |
| 3.2 Coupling of mitochondrial function and skeletal muscle fiber type by a miR-499/Fnipl/AMPK circuit | 第67-80页 |
| 3.2.1 MiR-499 reprograms skeletal muscle mitochondrial oxidative metabolism and enhances exercise capacity in mice | 第67-71页 |
| 3.2.2 MiR-499 drives muscle mitochondrial function through PGC-1α | 第71-75页 |
| 3.2.3 MiR-499 regulated PGC-1α-driven mitochondrial function is by directly targeting Fnipl/AMPK circuit | 第75-78页 |
| 3.2.4 Summary | 第78-80页 |
| 4. References | 第80-84页 |
| 5. Appendix | 第84-86页 |
| Acknowledgements | 第86-88页 |
| Publication | 第88-89页 |
