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Electroacupuncture at PC6 Modulates Inflammation in Myocardial Infarcted Rats

ABSTRACT第7-8页
PART Ⅰ: INTRODUCTION第9-19页
    1. Research significance第9-13页
        1.1 Public health burden of myocardial infarction (MI)第9-11页
        1.2 Treatment strategies and challenges for MI第11-13页
    2. Research scope and background第13-18页
        2.1 Inflammation in MI第13-16页
            2.1.1 Overview of inflammation in MI第13-14页
            2.1.2 Macrophage polarization in MI第14-15页
            2.1.3 Inflammation and oxidative stress第15页
            2.1.4 Neurohormonal modulation of inflammation第15-16页
        2.2 Acupuncture for MI and inflammation第16-18页
            2.2.1 Application of PC6 from TCM perspective第16-17页
            2.2.2 Acupuncture research for MI and inflammation第17-18页
    3. Research purpose & objectives第18-19页
PART Ⅱ: METHODS第19-25页
    1. Experimental Design第19-21页
        1.1 Experimental animals and groupings第19页
        1.2 MI model establishment第19-20页
        1.3 Electroacupuncture intervention at PC6第20-21页
    2. Assessment of myocardial injury & inflammation第21-25页
        2.1 Tissue & serum sample collection第21页
        2.2 Infarct size assessment第21页
        2.3 Myocardial enzyme analysis第21-22页
        2.4 Immunohistochemistry for macrophages第22页
        2.5 Western blot第22-23页
        2.6 Cytokine measurements第23页
        2.7 Oxidative stress evaluation第23页
        2.8 Sympathetic and RAAS activity第23-24页
        2.9 Statistical Analysis第24-25页
PART Ⅲ: RESULTS第25-32页
    1. Effect of EA infarct size第25-26页
    2. Effect of EA on myocardial enzyme levels第26-27页
    3. Effect of EA on macrophage polarization第27-28页
    4. Effect of EA on NF-κBp65 and CaMKⅡ expressions第28-29页
    5. Effect of EA on cytokine levels第29-30页
    6. Effect of EA on oxidative stress第30-31页
    7. Effect of EA on Sympathetic and RAAS activities第31-32页
PART Ⅳ: DISCUSSIONS第32-40页
    1. Post-MI EA intervention and its therapeutic potential第32-33页
    2. Immune-modulating effects of EA and its clinical implications in MI第33-36页
    3. Modulation of oxidative stress and neurohormonal overdrive by EA第36-40页
PART Ⅴ: LIMITATIONS & CONCLUSION第40-42页
    1. Study limitations第40-41页
    2. Conclusion第41-42页
REFERENCES第42-47页
ACKNOWLEDGEMENTS第47-48页
AUTHOR'S BRIEF INTRODUCTION第48页

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