| 摘要 | 第5-6页 |
| Abstract | 第6页 |
| Abbrevations | 第17-18页 |
| Chapter 1: Palladium-Catalyzed One-pot Highly Regioselective 6-EndoCyclization and Alkylation of Enynoates: Synthesis of 2-Alkanone Pyrones | 第18-102页 |
| 1.1 Introduction | 第18-19页 |
| 1.1.1 Introduction of Pyrone Compounds | 第18-19页 |
| 1.2 Application of Pyrone Compounds | 第19-28页 |
| 1.2.1 Biological Application | 第19-23页 |
| 1.2.2 Synthetic Application | 第23-28页 |
| 1.2.2.1 Synthetic Application of 2-pyrone in Diels-Alders cycloaddition reactions | 第23-25页 |
| 1.2.2.1.1 Acrylamide or acrylate as dienophile | 第24-25页 |
| 1.2.2.2 Metal-catalyzed coupling reaction | 第25-27页 |
| 1.2.2.3 Synthetic application of 2-pyrone in natural product synthesis | 第27页 |
| 1.2.2.4 Synthetic applications of 4-bromo-6-methyl-2-pyrone | 第27-28页 |
| 1.3 Methods for synthesis of multisubstituted 2-Pyrones Compounds | 第28-42页 |
| 1.3.1 Metal-Catalyzed Synthesis Methods | 第28-37页 |
| 1.3.1.1 Palladium-Catalyzed Synthesis | 第28-33页 |
| 1.3.1.2 Gold-Catalyzed Synthesis | 第33-35页 |
| 1.3.1.3 Rhodium-Catalyzed Synthesis | 第35-36页 |
| 1.3.1.4 Ruthenium-Catalyzed Synthesis | 第36-37页 |
| 1.3.1.5 Nickel-Catalyzed Synthesis | 第37页 |
| 1.3.2 Organo-Catalyzed Synthesis | 第37-38页 |
| 1.3.3 Phosphine-Catalyzed Synthesis | 第38-39页 |
| 1.3.4 Synthesis Method through Baylis-Hillman Reaction | 第39页 |
| 1.3.5 Synthesis Method via Iodolactonization | 第39-40页 |
| 1.3.6 Miscellaneous | 第40-42页 |
| 1.3.6.1 Ring expansion method | 第40页 |
| 1.3.6.2 Condensation | 第40-41页 |
| 1.3.6.3 Rearrangement cyclization method | 第41-42页 |
| 1.3.6.4 Synthesis of natural product | 第42页 |
| 1.4 Objective of the study | 第42-43页 |
| 1.5 Study on Palladium-Catalyzed Cyclization and Alkylation of Unsaturated Esters(Enynoates) | 第43-56页 |
| 1.5.1 Optimization of reaction conditions | 第44-46页 |
| 1.5.2 Expansion of substrate scope | 第46-51页 |
| 1.5.3 Speculation of reaction mechanism | 第51-52页 |
| 1.5.3.1 Evidences for proposed mechanism | 第52页 |
| 1.5.4 Summary | 第52-53页 |
| 1.5.5 Experimental section | 第53-56页 |
| 1.5.5.1 Methods and materials | 第53-54页 |
| 1.5.5.2 Preparation of (Z)-Enynoates | 第54页 |
| 1.5.5.3 Preparation of β-Substituted (Z)-Enynoates | 第54-55页 |
| 1.5.5.4 Procedure for the synthesis of 2-Alkanone Pyrones (I-3a-Ⅰ-3h), (I-4a-Ⅰ-4s),(I-5a-Ⅰ-51) | 第55-56页 |
| 1.6 Characterization and Spectral Data of Componds | 第56-86页 |
| 1.6.1 Characterization Data of Enynoates | 第56-59页 |
| 1.6.2 Characterization data of products (I-3a-Ⅰ-3h), (Ⅰ-4a-Ⅰ-4s), (I-5a-Ⅰ-51) | 第59-75页 |
| 1.6.3 Spectral Data of Representative Products | 第75-85页 |
| 1.6.4 X-ray Crystal data for compound I-5a | 第85-86页 |
| 1.7 References | 第86-102页 |
| Chapter 2: Copper-Catalyzed Regiodivergent 1,4- and 1,6-ConjugateAdditions of Silyl Reagent to the Diendioates | 第102-170页 |
| 2.1 Introduction | 第102-103页 |
| 2.1.1 Introduction of C-Si bond formation | 第102-103页 |
| 2.2 Application of C-Si bond containing compounds | 第103-109页 |
| 2.2.1 Synthetic applications | 第103-105页 |
| 2.2.2 Biological applications | 第105-109页 |
| 2.2.2.1 Anti-psychotics Agent | 第105页 |
| 2.2.2.2 HIV-1 Protease Inhibitor | 第105-106页 |
| 2.2.2.3 Angiotensin converting enzyme inhibitor (ACEI) | 第106页 |
| 2.2.2.4 Thermolysin Inhibitor | 第106页 |
| 2.2.2.5 p38a MAP Kinase Inhibitor | 第106-107页 |
| 2.2.2.6 Silicon Isosterism in Retinoids | 第107页 |
| 2.2.2.7 Anti-diarrheal Agent | 第107-108页 |
| 2.2.2.8 Acetylcholinesterase (ACNE) Activity | 第108页 |
| 2.2.2.9 Anti-allergic activity | 第108页 |
| 2.2.2.10 Anti-fungal activity | 第108-109页 |
| 2.3 Control of selectivity for the silyl addition to Michael acceptors | 第109页 |
| 2.4 Selective conjugate addition of silyl reagents | 第109-115页 |
| 2.4.1 1,4-Conjugate addition | 第110-113页 |
| 2.4.2 1,6-Conjugate addition | 第113-115页 |
| 2.4.3 Divergent 1,4- and 1,6-ACA of silyl reagent to the α,β,γ,δ-unsaturated carbonylderivatives | 第115页 |
| 2.5 Objective of the study | 第115-116页 |
| 2.6 Study on copper-catalyzed regiodivergent 1,4- and 1,6-conjugate additions ofsilyl reagent to the diendioates | 第116-129页 |
| 2.6.1 Optimization of reaction conditions | 第116-120页 |
| 2.6.2 Expansion of substrate scope | 第120-123页 |
| 2.6.3 Speculation of reaction mechanism | 第123-124页 |
| 2.6.4 Summary | 第124页 |
| 2.6.5 Experimental Section | 第124-129页 |
| 2.6.5.1 Method and materials | 第124-125页 |
| 2.6.5.2 Procedure for synthesis of diendioates | 第125-127页 |
| 2.6.5.3 Procedures for synthesis of 1,4- and 1,6-protosilylation adducts | 第127页 |
| 2.6.5.4 Synthetic applications of Compound (Ⅱ-3a) | 第127-129页 |
| 2.7 Characterization and Spectral Data of Compounds | 第129-162页 |
| 2.7.1 Characterization data of 1,4-addition products | 第129-138页 |
| 2.7.2 Characterization data of 1,6-addition Products | 第138-148页 |
| 2.7.3 Characterization data of synthetic application product | 第148-150页 |
| 2.7.4 Spectral data of Representative 1,4-addition Products | 第150-154页 |
| 2.7.5 Spectral data of Representative 1,6-addition Products | 第154-158页 |
| 2.7.6 Spectral data of Synthetic Applications | 第158-162页 |
| 2.8 References | 第162-170页 |
| Table of characterizations data of all the new compounds | 第170-174页 |
| List of Publications | 第174-176页 |
| Acknowledgements | 第176页 |
