| 详细摘要 | 第3-9页 |
| 英文摘要 | 第9-10页 |
| 摘要 | 第11-17页 |
| Capture 1 Review:Adipocytes and adaptive thermogenesis, and SCF/Kit | 第17-43页 |
| 1.1 Brown adipose tissue and adaptive thermogenesis | 第19-24页 |
| 1.1.1 Adipocytes can generate heat | 第19-20页 |
| 1.1.2 Induced thermogenesis in BAT | 第20-22页 |
| 1.1.3 1.1.3 Mechanisms of increased metabolic activity in BAT | 第22-24页 |
| 1.2 The Stem Cell Factor (SCF) and Kit | 第24-31页 |
| 1.2.1 The gene and protein structure of SCF and Kit | 第24-27页 |
| 1.2.2 SCF binding to Kit | 第27-28页 |
| 1.2.3 Downstream pathways of Kit | 第28-31页 |
| References | 第31-43页 |
| Capture 2:SCF and Kit, new players in adaptive thermogenesis | 第43-63页 |
| Introduction | 第45-46页 |
| Materials and methods | 第46-48页 |
| Results | 第48-57页 |
| 2.1 Serum SCF is altered in obese humans and animals | 第48-49页 |
| 2.2 Transcriptions of SCF and Kit are altered in obese mice model | 第49-51页 |
| 2.3 Transcriptions of SCF and Kit are altered during diet-induced thermogenesis | 第51-55页 |
| 2.4 Transcriptions of SCF and Kit are altered during cold-induced thermogenesis | 第55-57页 |
| Discussion | 第57-58页 |
| Contributions | 第58-59页 |
| Reference | 第59-63页 |
| Chapter 3:Wps, a novel Kit mutation, leads to obesity and cold intolerance | 第63-89页 |
| Introduction | 第65-66页 |
| Method | 第66-69页 |
| Results | 第69-81页 |
| 3.1 An novel Kit mutant mice | 第69-71页 |
| 3.2 Wps mutation is a Loss-of-function mutation | 第71-74页 |
| 3.3 Wps mutation disturbed energy homeostasis | 第74-78页 |
| 3.4 Reduced mitochondria and impaired adaptive thermogenesis in Wps/Wpsmice | 第78-81页 |
| Discussion | 第81-83页 |
| Contribution | 第83页 |
| References | 第83-89页 |
| Chapter 4:SCF directly effects on brown adipocyte and increase bodytemperature | 第89-107页 |
| Introduction | 第91-92页 |
| Method | 第92-96页 |
| Results | 第96-102页 |
| 4.1 SCF and Kit are critical for the function of brown adipocyte | 第96-100页 |
| 4.2 Ectopic expressing SCF in vivo influenced basal metabolic rote andadaptive thermogenesis | 第100-102页 |
| Discussion | 第102-103页 |
| Contribution | 第103页 |
| References | 第103-107页 |
| 致谢 | 第107-109页 |
| Publications | 第109-112页 |
