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癫痫大鼠模型中miR-134-5p和神经元迁移蛋白双皮质素(DCX)的异常表达

Abstract第10-12页
摘要第13-15页
1. Introduction第15-18页
    1.1. Problem statement第16页
    1.2. Research Hypothesis第16-17页
    1.3. Research objectives第17页
    1.4. Justification第17-18页
2. Material and Methods第18-24页
    2.1. Materials第18-19页
        2.1.1. Antibodies第18页
        2.1.2. Primers第18页
        2.1.3. Technologies第18-19页
    2.2. Methods第19-24页
        2.2.1. Purpose第19页
        2.2.2. Experimental animals第19页
        2.2.3. Rat model of epileptic tolerance第19页
        2.2.4 Tissue preparation第19页
        2.2.5. Western blotting第19-20页
        2.2.6. Preparing and homogenizing the samples第20页
        2.2.7. Expressions miR 134 by qPCR in the Hippocampi of mature rats第20-22页
        2.2.8. Immunohistochemical analysis of neurogenesis markers -neuronal migrationprotein DCX第22-23页
        2.2.9. Statistical analysis第23-24页
3. Results第24-28页
    3.1. Expression of neuronal migration protein.第24-25页
    3.2. Expression of miR1345p using q PCR第25页
    3.3. ANOVA. Tukey’s HSD (honest significant difference) test of the groups第25-26页
    3.4. Immunohistochemistry, the results of the experience in a animal models, under normal conditions and in case of epilepsy, the expression of a neuronal migration protein- DCX第26-28页
4. Discussion第28-32页
5. Conclusion第32-33页
6. References第33-38页
Literature review第38-50页
    1. Review第38页
    2. Epilepsy第38-40页
        2.1. Statistical evidence第38-39页
        2.2. The pathogenesis of epilepsy and the risk factors第39页
        2.3. Epilepsy and new opportunities第39-40页
    3. Epilepsy and MicroRNA-134第40-42页
        3.1. Micro RNA第40页
        3.2. The other author’s study associated with epilepsy and micro RNA-134.第40-41页
        3.3.The relationship between Micro RNA-134 and DCX第41-42页
    4. Epilepsy and DCX第42-43页
        4.1. Neuronal migration protein (DCX) and how it works第42-43页
        4.2. The expression of DCX in experimental models from the other authors第43页
    5. The prospects for neurogenesis第43页
    6. New investigation against epilepsy and the introduction of therapy in the treatment ofepilepsy第43-44页
        6.1. The pathogenesis of epilepsy第43-44页
        6.2. Advances of new treatment of epilepsy第44页
    7. Conclusion第44-45页
    8. References第45-50页
Abbreviations第50-51页
Acknowledgements第51-52页

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