| Abstract in Chinese | 第1-4页 |
| Abstract in English | 第4-6页 |
| Content | 第6-9页 |
| List of Tables | 第9-10页 |
| List of Figures | 第10-16页 |
| List of Schemes | 第16页 |
| List of Abbreviations | 第16-19页 |
| Ⅰ Introduction | 第19-40页 |
| ·History of acyl-coenzyme A: cholesterol acyltransferase (ACAT) | 第19-20页 |
| ·Properties of acyl-coenzyme A: cholesterol acyltransferase (ACAT) | 第20-27页 |
| ·General properties | 第20-21页 |
| ·Cloning and functional expression of ACAT cDNAs | 第21-22页 |
| ·ACAT proteins | 第22-24页 |
| ·The functions of ACAT1 & 2 protein | 第24-26页 |
| ·ACAT as a pharmaceutical target | 第26-27页 |
| ·ACAT inhibitors | 第27-34页 |
| ·The progress of research in ACAT inhibitors | 第27-28页 |
| ·Four classes of ACAT inhibitors | 第28-34页 |
| ·Lipoprotein-associated phospholipase A_2 | 第34-40页 |
| Ⅱ Materials and Methods | 第40-54页 |
| ·Materials and reagents | 第40-41页 |
| ·Assay of bioactivity inhibitors from insects | 第41-44页 |
| ·Screening of ACAT inhibitors from insects | 第41-42页 |
| ·Screening of Lp-PLA_2 inhibitors from insects | 第42页 |
| ·Assay of compounds inhibitory | 第42-44页 |
| ·Assay of ACAT inhibitory | 第42-43页 |
| ·Assay of Lp-PLA_2 inhibitory | 第43-44页 |
| ·Isolation and purification | 第44-54页 |
| ·Isolation and purification of ACAT inhibitors from P. brevitarsis | 第44-47页 |
| ·Isolation and purification of ACAT inhibitors from M. phalerate | 第47-49页 |
| ·Isolation and purification of ACAT inhibitors from A. parki | 第49-51页 |
| ·Isolation and purification of Lp-PLA_2 inhibitors from P.cavimanus | 第51-54页 |
| Ⅲ Results and Discussion | 第54-155页 |
| ·Preface | 第54-57页 |
| ·Characteristic of this project | 第54-55页 |
| ·The structures of purified compounds (1-13) | 第55-57页 |
| ·Screening of insects | 第57-65页 |
| ·Screening of insects for ACAT inhibitory activity (in vitro test) | 第57-59页 |
| ·Screening of insects for ACAT inhibitory activity (in vivo test) | 第59-60页 |
| ·Screening of insects for LDL antioxidant activity | 第60-61页 |
| ·Screening of insects for Lp-PLA2 inhibitory activity | 第61-64页 |
| ·Screening of insects for DGAT inhibitory activity | 第64-65页 |
| ·Biological properties of the compounds | 第65-70页 |
| ·The result of ACAT activity assay | 第65-68页 |
| ·The result of Lp-PLA2 activity assay | 第68-70页 |
| ·Structural determination of compounds | 第70-155页 |
| ·Structural determination of compounds as ACAT inhibitors from P. brevitarsis | 第70-90页 |
| ·Compound 1 | 第70-74页 |
| ·Compound 2 | 第74-82页 |
| ·Compound 3 (new) | 第82-90页 |
| ·Structural determination of compounds as ACAT inhibitors from M. phalerate | 第90-120页 |
| ·Compound 4 | 第90-97页 |
| ·Compound 5 | 第97-104页 |
| ·Compound 6 | 第104-110页 |
| ·Compound 7 | 第110-116页 |
| ·Compound 8 | 第116-120页 |
| ·Structural determination of compounds as ACAT inhibitors from A. parki | 第120-137页 |
| ·Compound 9 | 第120-126页 |
| ·Compound 10 | 第126-137页 |
| ·Structural determination of compounds as Lp-PLA2 inhibitors from P. cavimanus | 第137-155页 |
| ·Compound 11 | 第137-144页 |
| ·Compound 12 | 第144-149页 |
| ·Compound 13 | 第149-155页 |
| Ⅳ Conclusion | 第155-156页 |
| Background in Chinese | 第156-162页 |
| Acknowledgments | 第162-164页 |
| Curriculum vitae | 第164-165页 |
| Publications and contribution of meetings | 第165-166页 |
