| 摘要 | 第1-8页 |
| ABSTRACT | 第8-16页 |
| Chapter 1 Research Background | 第16-28页 |
| ·Diagnostic test | 第16-17页 |
| ·Methods and indicators for the evaluation of diagnostic test | 第17-19页 |
| ·Sensitivity and specificity | 第19-21页 |
| ·ROC curve | 第21-23页 |
| ·Youden index | 第23-24页 |
| ·The hypothesis for Youden index | 第24-27页 |
| ·Current Research | 第27页 |
| ·Objective | 第27-28页 |
| Chapter 2 Statistical Inference Method for Single Youden Index | 第28-47页 |
| ·Presence of the problems | 第28-31页 |
| ·Delta method | 第31-33页 |
| ·(1-α)·100%confidence interval and statistical inference method | 第33-34页 |
| ·Relative proof | 第34-36页 |
| ·Hypothesis Test for Single Youden Index | 第36-43页 |
| ·Real example | 第43-46页 |
| ·Conclusions | 第46-47页 |
| Chapter 3 Statistical Inference Method for Paired Youden Index | 第47-79页 |
| ·Presence of the problems | 第47页 |
| ·Association of paired Youden index | 第47-48页 |
| ·Decomposition of the variance of the Youden index | 第48-50页 |
| ·Association between sensitivities(specificities)of different diagnostic test | 第50-54页 |
| ·Association between sensitivity and specificity of single diagnostic test | 第54-56页 |
| ·Association between sensitivity and specificity of different diagnostic tests | 第56页 |
| ·Covariance for Paired Youden Index | 第56-62页 |
| ·Estimation of the standard error of paired Youden index | 第62页 |
| ·(1-α)100% confidence interval for the deviation of paired Youden index | 第62页 |
| ·Establishing of the statistic | 第62-63页 |
| ·Relative proof | 第63-65页 |
| ·Power and type Ⅰ error | 第65-73页 |
| ·Real example | 第73-76页 |
| ·Discussion | 第76-77页 |
| ·Conclusions | 第77-79页 |
| Chapter 4 Discussions and Conclusions | 第79-90页 |
| ·Statistical inference method for single Youden index | 第80-81页 |
| ·Estimation of the association and covariance of paired rates | 第81-83页 |
| ·Estimation of the covariances between sensitivities(specificities) | 第83-84页 |
| ·Statistical inference method for paired Youden index | 第84-85页 |
| ·The deficiency of the research | 第85-89页 |
| ·Conclusions | 第89-90页 |
| References | 第90-92页 |
| Appendix | 第92-93页 |
| Publications during the graduate study | 第93-94页 |
| 致谢 | 第94-95页 |
