| Acknowledgements | 第1-11页 |
| Abstract | 第11-17页 |
| 摘要 | 第17-20页 |
| Chapter 1 Introduction | 第20-25页 |
| Chapter 2 Literature Review and Background Knowledge | 第25-44页 |
| ·The Challenges on Statistical Methods for Complex Trait Analysis | 第25-34页 |
| ·The applications of mixed linear model approaches in quantitative genetics and their drawbacks in large-scale data analysis | 第25-27页 |
| ·Linkage analysis of quantitative trait loci(QTLs)and its challenges in post-genomics era | 第27-32页 |
| ·Statistical issues in analysis of expression traits | 第32-34页 |
| ·Commonly Used Approaches for Parameter Estimation and Statistical Inference of Mixed Linear Models | 第34-39页 |
| ·Estimation of variance components and significance tests | 第35-37页 |
| ·Analysis of fixed and random effects | 第37-39页 |
| ·HAB(Henderson and Bayesian)Method for Analysis of Mixed Linear Models | 第39-44页 |
| ·Test significant of multiple effects by Henderson method Ⅲ | 第39-41页 |
| ·Bayesian analysis of mixed linear model via Gibbs sampling | 第41-44页 |
| Chapter 3 Mapping the Genetic Architecture of Complex Traits in Experimental Populations | 第44-116页 |
| ·Mapping the Genetic Architecture of Complex Traits by Homogeneous Mapping Panel | 第44-64页 |
| ·Introduction | 第44-46页 |
| ·Methods | 第46-53页 |
| ·Results | 第53-60页 |
| ·Discussion | 第60-64页 |
| ·Mapping Genetic Architecture of Complex Traits by Heterogeneous Mapping Panel | 第64-88页 |
| ·Introduction | 第64-67页 |
| ·Methods | 第67-72页 |
| ·Results | 第72-82页 |
| ·Discussion | 第82-85页 |
| ·Appendix | 第85-88页 |
| ·Mapping Quantitative Trait Loci Based on Diversity Arrays Technology(DArT) | 第88-104页 |
| ·Introduction | 第88-90页 |
| ·Methods | 第90-93页 |
| ·Results | 第93-101页 |
| ·Discussion | 第101-104页 |
| ·Predicting Superior Genotypes Based on QTL Effects | 第104-116页 |
| ·Introduction | 第104-105页 |
| ·Methods | 第105-108页 |
| ·Worked example | 第108-111页 |
| ·Discussion | 第111-113页 |
| ·Appendix | 第113-116页 |
| Chapter 4 Mapping the Interspecific Genetic Architecture in Host-Parasite Interaction System | 第116-132页 |
| ·Introduction | 第116-118页 |
| ·Genetic Models | 第118-120页 |
| ·Methodology of QTL Mapping | 第120-126页 |
| ·Scanning for QTLs in the host and parasite genomes | 第121-123页 |
| ·Detecting intra- and inter-genomic interactions between QTLs | 第123-125页 |
| ·Threshold determination and model selection | 第125-126页 |
| ·Monte Carlo Simulations | 第126-128页 |
| ·Discussion | 第128-132页 |
| Chapter 5 Genetic Analysis of Microarray Expression Data | 第132-154页 |
| ·Identifying Differentially Expressed Genes by Microarray Data with One- or Two-factor Design | 第132-147页 |
| ·Introduction | 第132-133页 |
| ·Methods | 第133-137页 |
| ·Data analysis and results | 第137-142页 |
| ·Discussion | 第142-147页 |
| ·Identifying QTL and Epistasis that Affect Gene Expression | 第147-154页 |
| ·Introduction | 第147-148页 |
| ·Methods | 第148-149页 |
| ·Results and discussion | 第149-154页 |
| Chapter 6 Software Development for Genetic Analysis of Complex Trait | 第154-167页 |
| ·QTLNetwork Software:Mapping and Visualizing Genetic Architecture of Complex Traits in Experimental Populations | 第154-160页 |
| ·Introduction | 第154-155页 |
| ·Method overview | 第155-157页 |
| ·Brief user instruction | 第157-158页 |
| ·Conclusions | 第158-160页 |
| ·QTModel Software:Analysis of Quantitative Traits by Mixed Linear Models | 第160-167页 |
| ·Introduction | 第160-161页 |
| ·Method overview | 第161-163页 |
| ·Brief user instruction | 第163-166页 |
| ·Conclusions | 第166-167页 |
| References | 第167-180页 |
| Publications | 第180-181页 |
