| Abstract | 第4页 |
| 摘要 | 第6-7页 |
| Chapter ⅠIntroduction | 第7-35页 |
| 1.1. Overview | 第7-8页 |
| 1.2. Hair cell regeneration potential of resident SCs in the inner ear | 第8-11页 |
| 1.3 Lgr5 marked SCs in the mammalian inner ear | 第11-12页 |
| 1.4 Factors affecting auditory HC regeneration after damage in mammals | 第12-15页 |
| 1.5 Epigenetic regulation in HC regeneration | 第15-20页 |
| 1.6 The role of Wnt signaling pathway in auditory HC development and regeneration | 第20-25页 |
| 1.7 Implication of canonical Wnt/β-catenin signaling in auditory HC regeneration | 第25-31页 |
| 1.8 Microarray Technology | 第31-33页 |
| 1.9 Aims of the study | 第33-35页 |
| Chapter Ⅱ In vivo lineage tracing of apical and basal Lgr5+ cells | 第35-44页 |
| 2.1 Introduction | 第35-38页 |
| 2.2 Materials and Methods | 第38-40页 |
| 2.3 Results and discussion | 第40-44页 |
| Chapter Ⅲ HC regeneration potential of apical and basal Lgr5+ cells in vitro | 第44-58页 |
| 3.1 Introduction | 第44-45页 |
| 3.2 Materials and Methods | 第45-48页 |
| 3.3 Results and discussion | 第48-58页 |
| Chapter Ⅳ Neurosphere formation and differentiation of apical and basal Lgr5+ cellsin vitro | 第58-66页 |
| 4.1 Introduction | 第58-59页 |
| 4.2 Materials and Methods | 第59-61页 |
| 4.3 Results and discussion | 第61-66页 |
| Chapter V Transcriptome expression profiles of apical and basal Lgr5+ cells | 第66-84页 |
| 5.1 Introduction | 第66-67页 |
| 5.2 Materials and Methods | 第67-69页 |
| 5.3 Results and discussion | 第69-84页 |
| Chapter VI Project summary and Future work plan | 第84-87页 |
| 6.1 Summary and conclusions | 第84-85页 |
| 6.2 Future directions | 第85-87页 |
| Appendix | 第87-88页 |
| Acknowledgement | 第88-89页 |
| References | 第89-101页 |
| Resume | 第101页 |
