| ACKNOWLEDGMENTS | 第1-6页 |
| ABSTRACT | 第6-9页 |
| 摘要 | 第9-11页 |
| TABLE OF CONTENTS | 第11-14页 |
| LIST OF FIGURES | 第14-17页 |
| LIST OF TABLES | 第17-18页 |
| ABBREVIATIONS | 第18-19页 |
| CHAPTER 1 INTRODUCTION | 第19-44页 |
| ·Tissue Engineering | 第19-21页 |
| ·Tissue Engineering Materials | 第21-26页 |
| ·Natural Polymers for Tissue Engineering | 第22-24页 |
| ·Synthetic Polymers for Tissue Engineering | 第24-26页 |
| ·Poly(α-hydroxy acids) | 第24-25页 |
| ·Poly(ε-caprolactone) | 第25-26页 |
| ·Polyanhydrides | 第26页 |
| ·Others | 第26页 |
| ·Demands for Preshaped Scaffolds for Tissue Engineering | 第26-27页 |
| ·Fabrication Methods of Preshaped Scaffolds for Tissue Engineering | 第27-39页 |
| ·Fiber Bonding | 第30-31页 |
| ·Particulate Leaching Method | 第31-32页 |
| ·Phase Separation | 第32-35页 |
| ·Rapid Prototyping Technique | 第35-36页 |
| ·Molding Method | 第36-38页 |
| ·Others | 第38-39页 |
| ·Surface Modification of Preshaped Scaffolds for Tissue Engineering | 第39-41页 |
| ·Objectives of This Thesis | 第41-44页 |
| CHAPTER 2 POLYMER SYNTHESIS AND FABRICATION OF POROUS SCAFFOLDS WITH IRREGULAR PORES | 第44-73页 |
| ·Introduction | 第44-45页 |
| ·Experimental | 第45-52页 |
| ·Chemicals | 第45页 |
| ·Synthesis of Polyesters | 第45-48页 |
| ·Polymerization of Poly(ε-caprolactone) (PCL) | 第45-46页 |
| ·Polymerization of Poly(D,L-lactic acid) (PDLLA) | 第46-47页 |
| ·Preparation of Poly(lactic acid-co-glycolic acid) (PLGA) | 第47-48页 |
| ·Preparation of Polymer Porous Scaffolds | 第48-49页 |
| ·Preparation of Porous Scaffolds by Casting Method | 第48-49页 |
| ·Preparation of Porous Scaffolds by Compression Molding & Particulate Leaching Method | 第49页 |
| ·In Vitro Degradation of Polymer Foams | 第49-50页 |
| ·Characterization | 第50-52页 |
| ·Molecular Weight Determination of Polyesters | 第50页 |
| ·Viscometry | 第50页 |
| ·Gel Permeation Chromatography (GPC) | 第50页 |
| ·Nuclear Magnetic Resonance (NMR) | 第50页 |
| ·Porosity Measurement of Porous Scaffolds | 第50-51页 |
| ·Thermal Properties Characterization of Scaffolding Materials | 第51-52页 |
| ·Microstructure Observation | 第52页 |
| ·Synthesis of Biodegradable Polyesters | 第52-56页 |
| ·Pore Structure and Porosity of Scaffold | 第56-68页 |
| ·Porosity of Porous Scaffolds | 第56-63页 |
| ·Microstructure of Porous Scaffolds | 第63-68页 |
| ·In vitro Degradation of Polymer Foams | 第68-72页 |
| ·Summary | 第72-73页 |
| CHAPTER 3 PREPARATION OF POLYMERIC TISSUE ENGINEERING SCAFFOLDS WITH ORDERED POROUS STRUCTURE | 第73-93页 |
| ·Introduction | 第73-74页 |
| ·Experimental | 第74-76页 |
| ·Materials | 第74-75页 |
| ·Preparation of Paraffin Spheres | 第75页 |
| ·Porous Scaffold Fabrication Based on Paraffin Spheres | 第75-76页 |
| ·Characterization of Porous Scaffolds | 第76页 |
| ·Porosity Measurement of Porous Scaffolds | 第76页 |
| ·SEM Observation of Porous Scaffolds | 第76页 |
| ·Light Microscopic Observation | 第76页 |
| ·Preparation of Paraffin Spheres | 第76-79页 |
| ·Fabrication of Porous Scaffolds Based on Paraffin Spheres | 第79-92页 |
| ·Porosity Modulation | 第82-84页 |
| ·Morphology of Spherical Pore Foams | 第84-92页 |
| ·Summary | 第92-93页 |
| CHAPTER 4 MECHANICAL PROPERTIES OF POROUS SCAFFOLDS | 第93-109页 |
| ·Introduction | 第93页 |
| ·Experimental | 第93-96页 |
| ·Materials | 第93-94页 |
| ·Porous Scaffolds Fabrication | 第94页 |
| ·Mechanical Measurement of Porous Scaffolds | 第94-96页 |
| ·Results and Discussion | 第96-107页 |
| ·Viscoelasticity of Porous Membranes | 第96-97页 |
| ·Pore Size Effect on Mechanical Properties of Porous Scaffolds | 第97-99页 |
| ·Porosity Effect on Mechanical Properties of Spherical Pore Scaffolds | 第99-100页 |
| ·Bimodal Pore Size Effect on Mechanical Properties of Porous Scaffolds | 第100-105页 |
| ·Comparison of Mechanical Properties of Porous Scaffolds Prepared with Different Pore Shapes | 第105-106页 |
| ·Linear Fit of Compressive Modulus of Porous Scaffolds | 第106-107页 |
| ·Summary | 第107-109页 |
| CHAPTER 5 BIOCOMPATIBILITY EVALUATION OF POROUS SCAFFOLDS | 第109-121页 |
| ·Introduction | 第109页 |
| ·Foams Preparation and Porogen Residue | 第109-111页 |
| ·Cytotoxicity of Foams | 第111-117页 |
| ·Cell Culture | 第112-113页 |
| ·Observations of Cells Cultured on the Porous Scaffolds | 第113-115页 |
| ·MTT Assay | 第115-117页 |
| ·Preliminary Examination of In Vivo Biocompatibility | 第117-120页 |
| ·Implantation of Porous Scaffolds in Animal Experiment | 第117-118页 |
| ·Histological Examination | 第118页 |
| ·Host Response to Porous Scaffolds | 第118-120页 |
| ·Summary | 第120-121页 |
| CHAPTER 6 CONCLUSIONS AND FUTURE PROSPECT | 第121-125页 |
| ·Conclusions | 第121-123页 |
| ·Problems and Future Prospect | 第123-125页 |
| REFERENCES | 第125-143页 |
| CURRICULUM VITAE | 第143-145页 |
| 论文独创性声明 | 第145页 |
| 论文使用授权声明 | 第145页 |
