| 摘要 | 第3-7页 |
| abstract | 第7页 |
| Chapter 1 Research Background | 第11-41页 |
| 1.1 Overview of Cancer | 第11-17页 |
| 1.1.1 Definitions | 第11页 |
| 1.1.2 Causes | 第11-12页 |
| 1.1.3 Therapeutic Method | 第12-17页 |
| 1.2 Classification of Antitumor Drugs | 第17-23页 |
| 1.2.1 Directly Acting on DNA | 第17-19页 |
| 1.2.2 Interfering with DNA Synthesis | 第19-22页 |
| 1.2.3 Inhibiting Mitosis | 第22-23页 |
| 1.3 Development Trend of Antitumor Drugs | 第23-26页 |
| 1.3.1 Targeted Antitumor Drugs | 第23-25页 |
| 1.3.2 Gene Therapy of Tumors | 第25页 |
| 1.3.3 Development Trend of other Antitumor Drugs | 第25-26页 |
| 1.4 Research Progress of Corannulene | 第26-34页 |
| 1.4.1 Molecular Structure | 第26-27页 |
| 1.4.2 Properties of Corannulene | 第27-30页 |
| 1.4.3 Synthesis of Corannulene | 第30-31页 |
| 1.4.4 Flash Vacuum Pyrolysis | 第31-32页 |
| 1.4.5 Kilogram Scale Synthesis in Solution | 第32-34页 |
| 1.5 Brief Introduction of DNA | 第34-41页 |
| 1.5.1 Interaction between Small Molecular Compounds and DNA | 第36-38页 |
| 1.5.2 Analysis and Testing Method for the Interaction between Drugs and DNA | 第38-41页 |
| Chapter 2 Project Design | 第41-45页 |
| 2.1 Basis of Selection of Thesis | 第41-43页 |
| 2.2 Design of Target Compounds | 第43页 |
| 2.3 Design of Organic Synthesis | 第43-45页 |
| Chapter 3 Experimental Data | 第45-59页 |
| 3.1 General Notes and Procedures | 第45-46页 |
| 3.2 Synthesis Procedures | 第46-59页 |
| 3.2.1 Synthesis and Characterization of Corannulene Bromide(2) | 第46页 |
| 3.2.2 Synthesis and Characterization of Ethynylcorannulene-TMS(3) | 第46-47页 |
| 3.2.3 Synthesis and Characterization of 1-Ethynylcorannulene(4) | 第47页 |
| 3.2.4 Synthesis and Characterization of 1,2,3,4,6-Penta-o-acetyl-D-glucopyranose(6) | 第47-48页 |
| 3.2.5 Synthesis and Characterization of 1,2,3,4,6-Penta-o-acetyl-D-mannopyranose(8) | 第48页 |
| 3.2.6 Synthesis and Characterization of 1,2,3,4,6-Penta-o-acetyl-D-galactopyranose(10) | 第48-49页 |
| 3.2.7 Synthesis and Characterization of 2,3,4,6-Tetra-o-Acetyl-β-D-glucopyranosyl azide(11) | 第49-50页 |
| 3.2.8 Synthesis and Characterization of 2,3,4,6-Tetra-o-acetyl-β-D-mannopyranosyl azide(12) | 第50页 |
| 3.2.9 Synthesis and Characterization of 2,3,4,6-Tetra-o-acetyl-β-D-galactopyranosyl azide(13) | 第50-51页 |
| 3.2.10 Synthesis and Characterization of Glucose Conjugate of Corannulene(15) | 第51-52页 |
| 3.2.11 Synthesis and Characterization of Mannose Conjugate of Corannulene(17) | 第52-53页 |
| 3.2.12 Synthesis and Characterization of Galactose Conjugate of Corannulene(19) | 第53-54页 |
| 3.2.13 Synthesis and Characterization of 3-Bromoperylene(21) | 第54-55页 |
| 3.2.14 Synthesis and Characterization of 3-[(Trimethylsilyl)ethynyl]perylene(22) | 第55页 |
| 3.2.15 Synthesis and Characterization of 3-Ethynylperylene(23) | 第55-56页 |
| 3.2.16 Synthesis and Characterization of Glucose Conjugate of Perylene(25) | 第56-57页 |
| 3.2.17 Synthesis and Characterization of Galactose Conjugate of Perylene(27) | 第57-58页 |
| 3.2.18 Synthesis and Characterization of Mannose Conjugate of Perylene(29) | 第58-59页 |
| Chapter 4 Discussion and Conclusion | 第59-63页 |
| 4.1 Analysis and Discussion on the Preparation of Compound 2 | 第59页 |
| 4.2 Analysis and Discussion on the Preparation of Compound 3 | 第59页 |
| 4.3 Analysis and Discussion on the Preparation of Compound 4 | 第59-60页 |
| 4.4 Analysis and Discussion on the Preparation of Compound 6,8,10 | 第60页 |
| 4.5 Analysis and Discussion on the Preparation of Compound 11-13 | 第60-61页 |
| 4.6 Analysis and Discussion on the Preparation of Compound 14,16,18 | 第61页 |
| 4.7 Analysis and Discussion on the Preparation of Compound 15,17,19 | 第61页 |
| 4.8 Analysis and Discussion on the Preparation of Compound 2 1 | 第61-62页 |
| 4.9 Analysis and Discussion on the Preparation of Compound 25,27,29 | 第62-63页 |
| Chapter 5 In Vitro Tests for the Biological Evaluation | 第63-67页 |
| 5.1 In vitro Antitumor Cytotoxicity Test | 第63-67页 |
| 5.1.1 Reagent and Instruments | 第63页 |
| 5.1.2 Experimental Principles | 第63-64页 |
| 5.1.3 Experimental Mothod | 第64页 |
| 5.1.4 Results and Discussion | 第64-67页 |
| Chapter 6 DNA Binding Studies | 第67-77页 |
| 6.1 Materials | 第67页 |
| 6.2 UV-vis Absorption Spectroscopic Characteristics | 第67-69页 |
| 6.2.1 Method | 第67页 |
| 6.2.2 Results and Discussion | 第67-69页 |
| 6.3 CD spectroscopy | 第69-73页 |
| 6.3.1 Method | 第69-70页 |
| 6.3.2 Results and Discussion | 第70-73页 |
| 6.4 Viscosity Measurements | 第73-77页 |
| 6.4.1 Method | 第73页 |
| 6.4.2 Results and Discussion | 第73-77页 |
| Chapter 7 Conclusion | 第77-79页 |
| References | 第79-93页 |
| Notes on Publications and Participation in Scientific Research | 第93-95页 |
| Appendix:Characterization of Synthetic Compounds | 第95-117页 |
| Acknowledgements | 第117页 |
