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中国东北地区精液异常男性不育患者的遗传学因素分析

中文摘要第4-7页
Abstract第7-11页
CONTENTS第12-15页
CHAPTER ONE INTRODUCTION第15-39页
    1.1 Male infertility第15-16页
    1.2 Influence factors of male inferility第16-39页
        1.2.1 Non-genetic factors of male infertility第16-22页
        1.2.2 Genetic factors of male infertility第22-35页
        1.2.3 Role of genetic disorders on abnormal semen quality第35-39页
CHAPTER TWO MATERIALS AND METHODS第39-47页
    2.1 Main reagents and instruments第39-40页
        2.1.1 Main reagents第39-40页
        2.1.2 The main instrument第40页
    2.2 Research objects第40-41页
    2.3 Patients information collection and sample collection第41-42页
    2.4 Terminologies associated with semen quality第42页
    2.5 Methods第42-47页
        2.5.1 Semen analysis第42页
        2.5.2 Karyotype analysis第42-43页
        2.5.3 Y chromosome microdeletions detection第43-45页
        2.5.4 Seminal fructose,neutral α-glucosidase enzyme assays第45页
        2.5.5 Serum reproductive hormone analysis第45-46页
        2.5.6 Statistical methods第46-47页
CHAPTER THREE RESULTS第47-81页
    3.1 Azoospermia results第47-58页
        3.1.1 Azoospermic patient's testicular volume第47页
        3.1.2 Azoospermic patient's seminal plasma biochemical levels第47-48页
        3.1.3 Azoospermic patient's Sex hormone levels第48-50页
        3.1.4 Azoospermic patient's chromosome karyotype第50页
        3.1.5 General information of azoospermic abnormal karyotype patients第50-54页
        3.1.6 Azoospermic patient's condition of Y chromosome microdeletions第54页
        3.1.7 General Information of azoospermic patients with Y chromosome microdeletions第54-58页
    3.2 Poor semen quality results第58-72页
        3.2.1 Poor semen quality patient's testicular volume第58页
        3.2.2 Poor semen quality patient's seminal plasma biochemical levels第58页
        3.2.3 Poor semen quality patient's sex hormone levels第58-62页
        3.2.4 Chromosomal abnormalities among poor semen quality patients第62页
        3.2.5 Abnormal karyotype poor semen quality patients and semen status第62-67页
        3.2.6 General information of abnormal karyotype poor semen quality patients第67-68页
        3.2.7 Comparison between oligozoospermic and cryptozoospermic men from non-moisaic Klinefelter syndrome group第68-70页
        3.2.8 AZF microdeletions results of patients with poor semen quality第70-72页
    3.3 Comparing azoospermic patients with poor semen quality patients第72-81页
        3.3.1 Azoospermic and poor semen quality patient's genetic factors第72页
        3.3.2 Azoospermic and poor semen quality patient's age and testicular volume第72-73页
        3.3.3 Azoospermic and poor semen quality patient's seminal plasma biochemical levels第73页
        3.3.4 Azoospermic and poor semen quality patient's sex hormone levels第73-81页
CHAPTER FOUR DISCUSSION第81-91页
    4.1 Abnormal karyotype第81-87页
        4.1.1 Klinefelter syndrome第81-83页
        4.1.2 47,XYY karyotype第83页
        4.1.3 45XX karyotype第83-84页
        4.1.4 Translocation anomalies第84-85页
        4.1.5 Chromosomal polymorphisms第85-86页
        4.1.6 Sex hormones levels第86-87页
    4.2 Y chromosome microdeletions第87-91页
CHAPTER FIVIE CONCLUSIONS第91-93页
REFERENCES第93-113页
ACHIEVEMENTS第113-114页
ABOUT AUTHOR第114-115页
ACKNOWLEDGEMENT第115页

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