| 摘要 | 第3-8页 |
| Abstract | 第8-9页 |
| Chapter1 Introduction on Modafinil | 第13-21页 |
| 1.1 Background on the discovery and development of Modafinil | 第13-16页 |
| 1.2 The mechanism of action of Modafinil | 第16-17页 |
| 1.3 Use of Modafinil in clinical and non-clinical applications | 第17-20页 |
| 1.3.1 The treatment of Narcolepsy | 第17页 |
| 1.3.2 The treatment of Obstructive Sleep Apnea | 第17-18页 |
| 1.3.3 The treatment of Shift Work Disorder | 第18页 |
| 1.3.4 Modafinil in Military Operations | 第18-19页 |
| 1.3.5 Modafinil as Cognitive Enhancer | 第19页 |
| 1.3.6 Modafinil in Off-label Medication | 第19-20页 |
| 1.4 Issues of Addiction to Modafinil | 第20-21页 |
| Chapter2 Literature Review on the Chemical Synthesis of Modafinil | 第21-33页 |
| 2.1 The Lafon Method | 第21-24页 |
| 2.2 The Carceller Method: | 第24-26页 |
| 2.3 The Mu Method: | 第26-27页 |
| 2.4 The Yao Method: | 第27-29页 |
| 2.5 The Fang Method: | 第29-30页 |
| 2.6 The Cephalon Method: | 第30-31页 |
| 2.7 The Chemagis Method: | 第31-33页 |
| Chapter3 Results and Discussions | 第33-51页 |
| 3.1 Assessment of the process for Modafinil | 第33-36页 |
| 3.2 The synthesis of benzhydrol2: | 第36-43页 |
| 3.2.1 Benzophenone reduction with sodium borohydride or potassium borohydride | 第37-39页 |
| 3.2.2 Hydrogenation of Benzophenone with Palladium on Carbon and Raney Nickel | 第39-41页 |
| 3.2.3 Hydrogenation of Benzophenone with palladium containing perovskites | 第41-43页 |
| 3.3 The synthesis of diphenylmethylthioacetic acid6: | 第43-45页 |
| 3.4 The synthesis of diphenylmethylthioacetamide13: | 第45-46页 |
| 3.5 The synthesis of diphenylmethylsulfinylacetamide(Modafinil)2: | 第46-49页 |
| 3.5.1 The Hydrogen Peroxide Oxidation | 第46-48页 |
| 3.5.2 The Oxone as an alternative to hydrogen peroxide oxidation | 第48-49页 |
| 3.6 The use of Oxone in Modafinil synthesis from the benzhdrol-thiourea one-pot sequence | 第49-51页 |
| Chapter4 Experimental Section | 第51-63页 |
| 4.1 General Points and Chemicals | 第51页 |
| 4.2 List of chemicals used for the experiments | 第51-54页 |
| 4.3 Reduction of Benzophenone with potassium borohydride | 第54页 |
| 4.4 Hydrogenation of Benzophenone with palladium on carbon(10%) | 第54页 |
| 4.5 Hydrogenation of Benzophenone with palladium on carbon-ethylenediamine | 第54-55页 |
| 4.6 Hydrogenation of Benzophenone with raney nickel | 第55页 |
| 4.7 Hydrogenation of Benzophenone with palladium containing perovskites | 第55-58页 |
| 4.7.1 Preparation of the perovskite La1.00Fe0.95Pd0.05O3 | 第55页 |
| 4.7.2 Preparation of the perovskite La1.00Fe0.90Pd0.10O3 | 第55-56页 |
| 4.7.3 Preparation of the perovskite La1.00Co0.95Pd0.05O3 | 第56页 |
| 4.7.4 Preparation of the perovskite La1.00Cu0.95Pd0.05O3 | 第56页 |
| 4.7.5 Preparation of the perovskite La1.00Al0.95Pd0.05O3 | 第56-57页 |
| 4.7.6 Hydrogenation of benzophenone with perovskite La1.00Fe0.95Pd0.05O3 | 第57页 |
| 4.7.7 Hydrogenation of benzophenone with perovskite La1.00Fe0.95Pd0.10O3 | 第57页 |
| 4.7.8 Hydrogenation of benzophenone with perovskite La1.00Co0.95Pd0.05O3 | 第57页 |
| 4.7.9 Hydrogenation of benzophenone with perovskite La1.00Cu0.95Pd0.05O3 | 第57-58页 |
| 4.7.10 Hydrogenation of benzophenone with perovskite La1.00Al0.95Pd0.05O3 | 第58页 |
| 4.8 The synthesis of diphenylmethylthioacetic acid | 第58-59页 |
| 4.8.1 Using acetic acid as both solvent and catalyst | 第58页 |
| 4.8.2 Using trifluoroacetic acid as both solvent and catalyst | 第58页 |
| 4.8.3 Using trifluoroacetic acid as catalyst and toluene as solvent | 第58-59页 |
| 4.9 The synthesis of diphenylmethylthioacetamide | 第59-60页 |
| 4.10 The synthesis of diphenylmethylsulfinylacetamide(Modafinil) | 第60-61页 |
| 4.11 The one-pot synthesis of Modafinil using the benzhydrol-thiourea-Oxone protocol | 第61-63页 |
| Chapter5 Conclusions | 第63-65页 |
| References | 第65-73页 |
| Appendices | 第73-75页 |
| Notes on publications and participation in scientific research | 第75-77页 |
| Acknowledgements | 第77页 |
