| 摘要 | 第1-8页 |
| Abstract | 第8-10页 |
| 1 INTRODUCTION | 第10-28页 |
| ·Bio-Sensing Systems | 第10-16页 |
| ·Types of Bio-Sensors | 第13页 |
| ·Applications of Bio-Sensors | 第13-15页 |
| ·Brief Explanation of the Functional Component based on Figure 1.1 | 第15页 |
| ·Makings of an Ideal Bio-sensor are as follows | 第15-16页 |
| ·Controlled Release Systems | 第16-18页 |
| ·To Mention further We Highlight the three main stages in the development of Controlled Release Technology | 第17-18页 |
| ·Basics of Fiber Optics | 第18-21页 |
| ·Fiber-Optics and Waveguides | 第18页 |
| ·What Are the Unique Advantages and Current Limitations of FOCSs? | 第18-19页 |
| ·Signal Conversion in the Sensor System | 第19-20页 |
| ·Example of Sensor Configuration | 第20-21页 |
| ·Nanotechnology | 第21-26页 |
| ·Some Promising Methods in Molecular Electronics and Nanotechnology | 第24-26页 |
| ·Future Endeavors | 第26页 |
| References | 第26-28页 |
| 2 BIO-SENSORS AND CONTROLLED RELEASE SYSTEMS SIMULATIONS USINGHPC FRAMEWORK & SUPERCOMPUTER | 第28-52页 |
| ·Introduction | 第28页 |
| ·Bio-Sensor Simulations | 第28-30页 |
| ·Mathematical Models | 第30-38页 |
| ·Model of Optical Fiber Bio-Sensors | 第30-32页 |
| ·The Signal amplification of the Optical Fiber Bio-Sensor in a trigger or sensingmode | 第32页 |
| ·Digital simulation Using High Performance Computational Platforms-64 BitMachines | 第32-36页 |
| ·The Dependence of the Amplification on the Substrate Concentration | 第36-38页 |
| ·The Effect of the Membrane Thickness on the Response Time | 第38页 |
| ·Controlled Release Systems Simulations | 第38-45页 |
| ·Mathematical Modeling | 第39页 |
| ·Mathematical Model of Bio-Molecular Controlled Release | 第39-40页 |
| ·In our general case the equation are written as follows | 第40-43页 |
| ·The Binding of Charged/Uncharged Micro-spheres onto a Bio-Surface is Modeledas shown in a case study using Lysozyme | 第43-44页 |
| ·Additional Information on Drug Release | 第44-45页 |
| ·Simplified Flow Chart Representations of Simulations | 第45-49页 |
| ·Concluding Remarks | 第49-50页 |
| References | 第50-52页 |
| 3 OPTICAL FIBER BASED BIO-SENSORS IMPLEMENTATION FRAMEWORK BASEDON FABRICATION AND ANALYSIS | 第52-84页 |
| ·Introduction | 第52-55页 |
| ·Explanation of the Classification of Bio-Sensors according to Bio-ReceptorSystem | 第53-55页 |
| ·Fabrication of Bio-sensors Based on Optical Fibers | 第55-60页 |
| ·Research aims for a new Optical-Fiber Bio-Sensor & Protocols | 第55-57页 |
| ·Description of Fiber Cleaning and Silanization Process | 第57-58页 |
| ·Bio-Sensor Fabrication Arrangement before Filling of Immunoassay in PKAKHolder | 第58页 |
| ·Bio-Sensor Fabrication Arrangement after Filling of Immunoassay in pKAK Holder | 第58-60页 |
| ·Main Procedure to build an Optical-Fiber based immunosensor | 第60页 |
| ·Analysis of Bio-sensors Using SEM/CL/PMT TECHNIQUES | 第60-81页 |
| ·Biological Samples | 第61-62页 |
| ·Resolution of SEM | 第62-63页 |
| ·Strengths and Limitation of SEM | 第63-64页 |
| ·SEM Micro-Graphs of Bio-Sensor Chemical Interfaces based on Optical-Fibers | 第64-68页 |
| ·Chemiluminescence | 第68-69页 |
| ·Liquid -Phase Reaction with Luminol | 第69-70页 |
| ·CL and its Measurement | 第70-71页 |
| ·PMT Instrumentation System | 第71-75页 |
| ·Photon Counting Method | 第75-76页 |
| ·Operating Method and characteristics of Photon Counting | 第76-77页 |
| ·Advantages of Photon Counting | 第77-78页 |
| ·PMT Applications | 第78-79页 |
| ·Spectrophotometry | 第79页 |
| ·Chemiluminescent Immunoassay | 第79-80页 |
| ·Optical Fiber based Bio-Sensor Response to Chemiluminescence based analysis | 第80-81页 |
| ·Concluding Remarks | 第81-82页 |
| References | 第82-84页 |
| 4 OPTICAL-FIBER BASED CONTROLLED RELEASE SYSTEMS IMPLEMENTATION FRAMEWORK BASED ON FABRICATION AND ANALYSIS | 第84-114页 |
| ·Introduction | 第84-91页 |
| ·Diffusion-Controlled Systems | 第84-85页 |
| ·Water Penetration-Controlled Systems | 第85-87页 |
| ·Biodegradable Drug Delivery Systems | 第87-88页 |
| ·Responsive Drug Delivery Systems | 第88-89页 |
| ·Other Drug Delivery Systems | 第89-91页 |
| ·Research Goals | 第91页 |
| ·Fabrication of Simple Nanobio Controlled Release Platform | 第91-95页 |
| ·Materials and Methods -Chemical Modification of Optical Fibers./Fiber Cleaning and Silanization | 第91-92页 |
| ·Description of Optimization of fiber Silanization in Nitrogen Gas Flow and theReactor Setup | 第92页 |
| ·Glycine Micro/Nano-Spheres Preparation and Usage and Amino AcidsBehaviour in Aqueous Environments | 第92-95页 |
| ·HIFU Experiment to Demonstrate Controlled Release | 第95-100页 |
| ·High Intensity Focused Ultrasound System -HIFU Systems in Controlled Release | 第95-96页 |
| ·HOW A HIFU SYSTEM WORKS | 第96-97页 |
| ·[Procedure/Protocols/Processes] | 第97-98页 |
| ·PART B | 第98-99页 |
| ·Additional Experimental Details -PART C | 第99-100页 |
| ·Analysis of the Controlled Release Process Using SEM/RAMAN SPECTROSCOPY/PH INDICATION TECHNIQUES | 第100-111页 |
| ·SEM | 第100-105页 |
| ·Raman Spectroscopy | 第105-111页 |
| ·Concluding Remarks | 第111页 |
| ·Additional Information on Commercial Products | 第111-112页 |
| References | 第112-114页 |
| 5 CONCLUSIONS & FUTURE PERSPECTIVES | 第114-117页 |
| PATENTS AND PUBLICATIONS | 第117-119页 |
| ACKNOWLEDGEMENT | 第119-120页 |
| APPENDIX | 第120-127页 |
