| Acknowledgement | 第4-5页 |
| 摘要 | 第5-12页 |
| Abstract | 第12页 |
| List of Abbreviations | 第16-19页 |
| Chapter 1:Introduction | 第19-21页 |
| Chapter 2: Literature Review | 第21-44页 |
| 2.1: Sources of Marine Antibiotics | 第21-24页 |
| 2.1.1: Marine Invertebrates | 第21-23页 |
| 2.1.1.1: Marine Sponges | 第22-23页 |
| 2.1.2: Marine Microorganisms (Bacteria and Fungi) | 第23-24页 |
| 2.2 Chemistry and Activities of Marine Antibiotics | 第24-36页 |
| 2.2.1: Antibiotics in Protein/Polypeptide Class | 第25-27页 |
| 2.2.2: Antibiotics in Polyketide/Macrolactones Class | 第27-31页 |
| 2.2.3: Antibiotics in Anthroquinone Class | 第31-33页 |
| 2.2.4: Antibiotics in Terpenoid Class | 第33-34页 |
| 2.2.5: Antibiotics in Alkaloid Class | 第34-36页 |
| 2.3: Some Strategies to Isolate Unculturable Microorganisms, Unlock Cryptic GeneClusters or Enhance Antibiotics Capacities against Resistant Strains | 第36-42页 |
| 2.4: Aim and Objectives | 第42-44页 |
| Chapter 3: Stress-Driven Discovery of Novel Cryptic Antibiotics from a MarineFungus Penicillium sp. BB1122 | 第44-69页 |
| 3.1: Materials and Methods | 第44页 |
| 3.1.1: General Experimental Procedures | 第44页 |
| 3.2: Isolation of the Fungal Strain | 第44-45页 |
| 3.3: Normal and Metal-Stress Cultivation | 第45-46页 |
| 3.3.1: Fermentation in Large Scale | 第45-46页 |
| 3.4: Extraction,HPLC-Guided Isolation, and Identification of Stress Metabolites | 第46-47页 |
| 3.5: Computation Section | 第47页 |
| 3.6: Results and Discussion | 第47-69页 |
| 3.6.1: Novel Compounds Elucidation | 第50-66页 |
| 3.6.1.1: Compound 1 | 第50-57页 |
| 3.6.1.2: Compound 7 | 第57-61页 |
| 3.6.1.3: Compound 8 | 第61-63页 |
| 3.6.1.4: Compound 5 | 第63-66页 |
| 3.6.2: Known Compounds Elucidation | 第66-69页 |
| Chapter 4: Biological Activity, Cytotoxicity and Possible Mode of Action of NovelCryptic Antibiotics from Penicillium sp. BB1122 | 第69-73页 |
| 4.1: Antibiotic Activity Screening of Stress Metabolites | 第69-70页 |
| 4.1.1: Determination of MIC and MBC | 第69-70页 |
| 4.1.2: Cytotoxicity Assay | 第70页 |
| 4.2: Results of Biological Activity and Cytotoxicity | 第70-71页 |
| 4.3: Possible Mode of Action | 第71-73页 |
| Chapter 5: Conclusion | 第73-75页 |
| References | 第75-86页 |
| Appendix | 第86-138页 |
| Resume | 第138-140页 |
