| 摘要 | 第1-8页 |
| ABSTRACT | 第8-12页 |
| Chapter 1 Literature review | 第12-28页 |
| ·High-fructose corn syrup (HFCS) consumption and obesity: the association with metabolic conditions | 第12-13页 |
| ·Potential obesity mechanisms for the detrimental effects of fructose | 第13-14页 |
| ·Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) | 第14-18页 |
| ·The chemistry of reactive oxygen species | 第18-19页 |
| ·Reactive carbonyl species (RCS), carbonyl stress, advanced glycation endproducts (AGEs) and lipoxidation end-products (ALEs) | 第19-20页 |
| ·Fructose and its metabolites: endogenous toxins | 第20-22页 |
| ·Fructose toxicity in vivo or following liver perfusion | 第22页 |
| ·Oxidative stress and antioxidants | 第22-23页 |
| ·Polyphenol antioxidants and anti-oxidative stress | 第23页 |
| ·Polyphenol antioxidants in commonly consumed nuts | 第23-24页 |
| ·Mechanisms of polyphenol antioxidants in nuts against oxidative Stress | 第24-25页 |
| ·Catechins: a type of dietary bioactive compounds | 第25-27页 |
| ·Scope of thesis | 第27页 |
| ·Hypothesis | 第27-28页 |
| Chapter 2 Endogenous toxins: cytotoxic mechanisms of fructose and its metabolites in rat hepatocytes | 第28-52页 |
| ·Introduction | 第28-29页 |
| ·Materials and methods | 第29-32页 |
| ·Results | 第32-39页 |
| ·Discussion | 第39-50页 |
| ·Conclusion | 第50-52页 |
| Chapter 3 Cytoprotection almond skin extracts or catechins of hepatocyte cytotoxicity induced by oxidative stress model versus carbonylation model | 第52-70页 |
| ·Introduction | 第52-53页 |
| ·Materials and methods | 第53-58页 |
| ·Results | 第58-64页 |
| ·Discussion | 第64-69页 |
| ·Conclusion | 第69-70页 |
| Chapter 4 Conclusion and Future perspectives | 第70-74页 |
| ·Conclusion | 第70-71页 |
| ·Future perspectives | 第71-74页 |
| REFERENCES | 第74-83页 |
| LIST OF ABBREVIATIONS | 第83-86页 |
| ACKNOWLEDGEMENTS | 第86-87页 |
| INTRODUCTION OF THE AUTHOR | 第87页 |
