| List of Abbreviations | 第8-10页 |
| Abstract (English) | 第10-11页 |
| Abstract (Chinese) | 第12-14页 |
| Innovations | 第14-15页 |
| 论文创新之处 | 第15-16页 |
| Chapter Ⅰ General Introduction | 第16-36页 |
| 1.1 Hypouricemic and Renal Protective Effects of Quercetin | 第18-20页 |
| 1.2 Lipid-lowering Effects of Quercetin | 第20-22页 |
| 1.3 Antioxidant and Anti-inflammatory Effects of Quercetin | 第22-27页 |
| 1.4 Other Effects of Quercetin | 第27-28页 |
| References | 第28-36页 |
| Chapter Ⅱ Hypothesis and Objectives | 第36-44页 |
| 2.1 Introduction | 第36-37页 |
| 2.1.1 Diabetes and Inflammation | 第36-37页 |
| 2.1.2 Inflammation and Kidney Injury | 第37页 |
| 2.2 Hypothesis and Objectives of the Present Study | 第37-39页 |
| References | 第39-44页 |
| Chapter Ⅲ Effects of Quercetin on the Basic Characteristics of Streptozocin-induced Diabetes | 第44-61页 |
| 3.1 Introduction | 第44-45页 |
| 3.2 Materials | 第45-46页 |
| 3.2.1 Animals and Animal Husbandry | 第45-46页 |
| 3.2.2 Reagents and Instrument | 第46页 |
| 3.3 Methods | 第46-47页 |
| 3.3.1 Induction, Assessment and Drug Treatment of Diabetes | 第46-47页 |
| 3.3.2 Urine Collection | 第47页 |
| 3.3.3 Determination of serum Glucose, Lipids, L- carnitine and Inflammatory Cytokine levels | 第47页 |
| 3.3.4 Statistical Analysis | 第47页 |
| 3.4 Results | 第47-55页 |
| 3.4.1 Effects of Quercetin and Allopurinol on the Body Weight and Glucose Levels of STZ-induced Diabetic Rats | 第47-49页 |
| 3.4.2 Effects of Quercetin and Allopurinol on Blood Glucose Levels of STZ-induced Diabetic Rats | 第49页 |
| 3.4.3 Effects of Quercetin and Allopurinol on Urine Volume, Water Intake and Food Intake Levels of STZ-induced Diabetic Rats | 第49-52页 |
| 3.4.4 Effects of Quercetin and Allopurinol on Serum Lipids and L- carnitine Levels of STZ-induced Diabetic Rats | 第52页 |
| 3.4.5 Effects of Quercetin and Allopurinol on Serum Inflammatory Cytokine Levels of STZ-induced Diabetic Rats | 第52-55页 |
| 3.5 Discussion | 第55-57页 |
| References | 第57-61页 |
| Chapter IV Effects of Quercetin on Kidney Lipid Accumulation, Kidney Injury and Inflammation in Streptozocin-induced Diabetes | 第61-104页 |
| 4.1 Introduction | 第61-62页 |
| 4.2 Materials | 第62-63页 |
| 4.2.1 Animals | 第63页 |
| 4.2.2 Reagents and Instrument | 第63页 |
| 4.3 Methods | 第63-69页 |
| 4.3.1 Biological Samples | 第63页 |
| 4.3.2 Measurement of Biochemical Parameters | 第63-64页 |
| 4.3.3 Histology for Kidney Tissue | 第64页 |
| 4.3.4 Semi-Quantitative PCR | 第64-67页 |
| 4.3.5 Western Blot | 第67页 |
| 4.3.6 Preparation for Brush-border Membrane Vesicle (BBMV) | 第67-68页 |
| 4.3.7 Statistical Analysis | 第68-69页 |
| 4.4 Results | 第69-94页 |
| 4.4.1 Effects of Quercetin and Allopurinol on Quot of Kidney and Urine Protein of STZ-induced Diabetic Rats | 第69-70页 |
| 4.4.2 Effects of Quercetin and Allopurinol on Uric acid, Creatinine and Blood urea nitrogen (BUN) Levels in Serum and 24-hour Urine | 第70-74页 |
| 4.4.3 Effects of Quercetin and Allopurinol on Uric acid Excretion Related Organic Ion Transporters in Kidney of STZ-induced Diabetic Rats | 第74-77页 |
| 4.4.4 Effects of Quercetin and Allopurinol on Uric acid Reabsorption Related Organic Ion Transporter in Kidney of STZ-induced Diabetic Rats | 第77-80页 |
| 4.4.5 Effects of Quercetin and Allopurinol on the Morphological Changes and OCT1&2 Expressions in Kidney of STZ-induced Diabetic Rats | 第80-83页 |
| 4.4.6 Quercetin and Allopurinol Reduce Dyslipidemia and Renal Lipid Accumulation in Diabetic Rats | 第83-90页 |
| 4.4.7 Quercetin and Allopurinol Ameliorate Kidney Inflammation by Blocking the NLRP3 Inflammasome Activation in Diabetic Rats | 第90-94页 |
| 4.5 Discussion | 第94-97页 |
| References | 第97-104页 |
| Chapter V Summary and Recommendations | 第104-106页 |
| 5.1 Summary | 第104-105页 |
| 5.2 Recommendations for Future Research and Applications | 第105-106页 |
| 全文总结与研究展望 | 第106-108页 |
| 攻读学位期间发表论文与获奖情况 | 第108-109页 |
| Acknowledgements | 第109-110页 |
| GRANTS | 第110-111页 |
