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基于介孔二氧化硅纳米粒子的成像介导多功能诊疗纳米体系用于癌症的治疗

abstract第3-5页
中文摘要第6-15页
Chapter1 Literature review第15-43页
    1.1 Photothermal therapy第15-21页
        1.1.1 Inorganic materials in photothermal therapy第17-19页
            1.1.1.1 Gold nanostructures第17-18页
            1.1.1.2 Carbon nanomaterials第18-19页
            1.1.1.3 Other inorganic materials第19页
        1.1.2 Organic materials in photothermal therapy第19-21页
            1.1.2.1 Near infrared fluorescent dyes第19-20页
            1.1.2.2 Macromolecular polymer第20-21页
    1.2 Photodynamic therapy第21-24页
        1.2.1 The first generation photosensitizer第23页
        1.2.2 The second generation photosensitizer第23-24页
        1.2.3 The third generation photosensitizer第24页
    1.3 Combined therapy第24-27页
        1.3.1 Photothermal therapy combined photodynamic therapy第25-26页
        1.3.2 Phototherapy combined chemotherapy第26-27页
        1.3.3 Phototherapy combined immunotherapy第27页
    1.4 Research progress of mesoporous silica nanoparticles第27-29页
    1.5 Research progress of liposomes第29-32页
        1.5.1 Conventional Liposomes第30页
        1.5.2 pH-Sensitive Liposomes第30-31页
        1.5.3 Cationic Liposomes第31-32页
        1.5.4 Immunoliposomes第32页
        1.5.5 Long-Circulating Liposomes第32页
    1.6 Multi-model imaging guided visualization therapy第32-35页
        1.6.1 Near infrared fluorescence imaging第33页
        1.6.2 Photoacoustic imaging第33-34页
        1.6.3 Magnetic resonance imaging第34-35页
    1.7 Research project第35-43页
        1.7.1 Project design of AuNRs capped& Ce6-doped mesoporous silica nanorods第35-37页
        1.7.2 Project content of AuNRs capped& Ce6-doped mesoporous silica nanorods第37-38页
        1.7.3 Project design of liposome coated DOX@ Gd doped-mesoporous silica anoparticles第38-40页
        1.7.4 Project content of liposome coated DOX@ Gd doped-mesoporous silica nanoparticles第40-43页
Chapter2 The preparation and characterization of AuNRs-Ce6-MSNRs第43-53页
    2.1 Experimental sections第43-47页
        2.1.1 Experimental gents and instruments第43-45页
            2.1.1.1 Main agents used in experiments第43-44页
            2.1.1.2 Experimental instruments第44-45页
        2.1.2 Synthesis of AuNRs-Ce6-MSNRs第45页
        2.1.3 Characterization of AuNRs-Ce6-MSNRs第45-46页
        2.1.4 In vitro laser-responsive properties第46页
        2.1.5 Singlet oxygen generation detection第46页
        2.1.6 In vitro release of Ce第46-47页
    2.2 Results and discussions第47-53页
        2.2.1 Preparation and morphological appearance of AuNRs-Ce6-MSNRs第47-48页
        2.2.2 Evaluation of BET surface area and pore size第48-49页
        2.2.3 UV-Vis,IR spectra and line graph of size distribution第49-50页
        2.2.4 In vitro efficacy evaluation第50-53页
Chapter3 In vitro cell experiments of AuNRs-Ce6-MSNRs第53-59页
    3.1 Experimental sections第53-56页
        3.1.1 Experimental agents and instruments第53-54页
            3.1.1.1 Main agents used in experiments第53-54页
            3.1.1.2 Experimental instruments第54页
        3.1.2 In vitro photo-cytotoxicity第54-55页
        3.1.3 In vitro cellular uptake and SOG第55-56页
    3.2 Results and discussions第56-59页
        3.2.1 Cellular cytotoxicity assay第56-57页
        3.2.2 Cellular uptake and intercellular ROS detection第57-59页
Chapter4 In vivo anti-tumor effect of AuNRs-Ce6-MSNRs第59-67页
    4.1 Experimental sections第59-61页
        4.1.1 Experimental agents and instruments第59-60页
            4.1.1.1 Main agents used in experiments第59页
            4.1.1.2 Experimental instruments第59-60页
        4.1.2 Mouse models of tumor第60页
        4.1.3 In vivo infrared thermal imaging第60页
        4.1.4 In vivo& ex vivo fluorescence and photoacoustic imaging第60-61页
        4.1.5 In vivo phototoxicity studies第61页
    4.2 Results and discussions第61-67页
        4.2.1 In vivo thermal imaging第61-62页
        4.2.2 Fluorescence biodistribution and photoacoustic tomography第62-63页
        4.2.3 Therapeutic efficacy study第63-64页
        4.2.4 Histopathological studies第64-67页
Chapter5 Conclusions and outlook of AuNRs-Ce6-MSNRs第67-71页
    5.1 Conclusions第67-68页
    5.2 Outlook第68-71页
Chapter6 The preparation and characterization of DOX@GdMSNs-ICG-TSLs第71-81页
    6.1 Experimental sections第71-75页
        6.1.1 Experimental agents and instruments第71-73页
            6.1.1.1 Main agents used in experiments第71-72页
            6.1.1.2 Experimental instruments第72-73页
        6.1.2 Preparation of DOX@GdMSNs-ICG-TSLs第73-74页
        6.1.3 Characterization of DOX@GdMSNs-ICG-TSLs第74页
        6.1.4 In vitro photothermal effect第74页
        6.1.5 In vitro photodynamic effect第74-75页
        6.1.6 In vitro release experiment第75页
    6.2 Results and discussions第75-81页
        6.2.1 Preparation and morphological appearance of DOX@GdMSNs-ICG-TSLs第75-76页
        6.2.2 UV-Vis,IR spectra,XRD,BET and line graph of size distribution第76-78页
        6.2.3 In vitro Efficacy Evaluation第78-81页
Chapter7 In vitro cell experiments of AuNRs-Ce6-MSNRs第81-89页
    7.1 Experimental sections第81-84页
        7.1.1 Experimental agents and instruments第81-83页
            7.1.1.1 Main agents used in experiments第81-82页
            7.1.1.2 Experimental instruments第82-83页
        7.1.2 In vitro cytotoxicity第83-84页
        7.1.3 In vitro cellular uptake and SOG第84页
    7.2 Results and discussions第84-89页
        7.2.1 Cellular cytotoxicity assay第84-86页
        7.2.2 Cellular uptake and intercellular ROS detection第86-89页
Chapter8 In vivo anti-tumor effect of DOX@GdMSNs-ICG-TSLs第89-99页
    8.1 Experimental sections第89-92页
        8.1.1 Experimental agents and instruments第89-90页
            8.1.1.1 Main agents used in experiments第89页
            8.1.1.2 Experimental instruments第89-90页
        8.1.2 Mouse models of tumor第90页
        8.1.3 In vivo infrared thermal imaging第90页
        8.1.4 Near infrared fluorescence,photoacoustic and magnetic resonance imaging第90-91页
        8.1.5 In vivo antitumor efficiency第91-92页
    8.2 Results and discussions第92-99页
        8.2.1 In vivo thermal imaging第92-93页
        8.2.2 In vivo NIRF,PA and MR Imaging第93-96页
        8.2.3 Therapeutic efficacy study第96-97页
        8.2.4 Histopathological studies第97-99页
Chapter9 Conclusions and outlook of DOX@GdMSNs-ICG-TSLs第99-103页
    9.1 Conclusions第99-101页
    9.2 Outlook第101-103页
References第103-119页
Appendix A第119-121页
Notes on publications and participation in scientific research第121-123页
Acknowledgement第123页

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