| abstract | 第3-5页 |
| 中文摘要 | 第6-15页 |
| Chapter1 Literature review | 第15-43页 |
| 1.1 Photothermal therapy | 第15-21页 |
| 1.1.1 Inorganic materials in photothermal therapy | 第17-19页 |
| 1.1.1.1 Gold nanostructures | 第17-18页 |
| 1.1.1.2 Carbon nanomaterials | 第18-19页 |
| 1.1.1.3 Other inorganic materials | 第19页 |
| 1.1.2 Organic materials in photothermal therapy | 第19-21页 |
| 1.1.2.1 Near infrared fluorescent dyes | 第19-20页 |
| 1.1.2.2 Macromolecular polymer | 第20-21页 |
| 1.2 Photodynamic therapy | 第21-24页 |
| 1.2.1 The first generation photosensitizer | 第23页 |
| 1.2.2 The second generation photosensitizer | 第23-24页 |
| 1.2.3 The third generation photosensitizer | 第24页 |
| 1.3 Combined therapy | 第24-27页 |
| 1.3.1 Photothermal therapy combined photodynamic therapy | 第25-26页 |
| 1.3.2 Phototherapy combined chemotherapy | 第26-27页 |
| 1.3.3 Phototherapy combined immunotherapy | 第27页 |
| 1.4 Research progress of mesoporous silica nanoparticles | 第27-29页 |
| 1.5 Research progress of liposomes | 第29-32页 |
| 1.5.1 Conventional Liposomes | 第30页 |
| 1.5.2 pH-Sensitive Liposomes | 第30-31页 |
| 1.5.3 Cationic Liposomes | 第31-32页 |
| 1.5.4 Immunoliposomes | 第32页 |
| 1.5.5 Long-Circulating Liposomes | 第32页 |
| 1.6 Multi-model imaging guided visualization therapy | 第32-35页 |
| 1.6.1 Near infrared fluorescence imaging | 第33页 |
| 1.6.2 Photoacoustic imaging | 第33-34页 |
| 1.6.3 Magnetic resonance imaging | 第34-35页 |
| 1.7 Research project | 第35-43页 |
| 1.7.1 Project design of AuNRs capped& Ce6-doped mesoporous silica nanorods | 第35-37页 |
| 1.7.2 Project content of AuNRs capped& Ce6-doped mesoporous silica nanorods | 第37-38页 |
| 1.7.3 Project design of liposome coated DOX@ Gd doped-mesoporous silica anoparticles | 第38-40页 |
| 1.7.4 Project content of liposome coated DOX@ Gd doped-mesoporous silica nanoparticles | 第40-43页 |
| Chapter2 The preparation and characterization of AuNRs-Ce6-MSNRs | 第43-53页 |
| 2.1 Experimental sections | 第43-47页 |
| 2.1.1 Experimental gents and instruments | 第43-45页 |
| 2.1.1.1 Main agents used in experiments | 第43-44页 |
| 2.1.1.2 Experimental instruments | 第44-45页 |
| 2.1.2 Synthesis of AuNRs-Ce6-MSNRs | 第45页 |
| 2.1.3 Characterization of AuNRs-Ce6-MSNRs | 第45-46页 |
| 2.1.4 In vitro laser-responsive properties | 第46页 |
| 2.1.5 Singlet oxygen generation detection | 第46页 |
| 2.1.6 In vitro release of Ce | 第46-47页 |
| 2.2 Results and discussions | 第47-53页 |
| 2.2.1 Preparation and morphological appearance of AuNRs-Ce6-MSNRs | 第47-48页 |
| 2.2.2 Evaluation of BET surface area and pore size | 第48-49页 |
| 2.2.3 UV-Vis,IR spectra and line graph of size distribution | 第49-50页 |
| 2.2.4 In vitro efficacy evaluation | 第50-53页 |
| Chapter3 In vitro cell experiments of AuNRs-Ce6-MSNRs | 第53-59页 |
| 3.1 Experimental sections | 第53-56页 |
| 3.1.1 Experimental agents and instruments | 第53-54页 |
| 3.1.1.1 Main agents used in experiments | 第53-54页 |
| 3.1.1.2 Experimental instruments | 第54页 |
| 3.1.2 In vitro photo-cytotoxicity | 第54-55页 |
| 3.1.3 In vitro cellular uptake and SOG | 第55-56页 |
| 3.2 Results and discussions | 第56-59页 |
| 3.2.1 Cellular cytotoxicity assay | 第56-57页 |
| 3.2.2 Cellular uptake and intercellular ROS detection | 第57-59页 |
| Chapter4 In vivo anti-tumor effect of AuNRs-Ce6-MSNRs | 第59-67页 |
| 4.1 Experimental sections | 第59-61页 |
| 4.1.1 Experimental agents and instruments | 第59-60页 |
| 4.1.1.1 Main agents used in experiments | 第59页 |
| 4.1.1.2 Experimental instruments | 第59-60页 |
| 4.1.2 Mouse models of tumor | 第60页 |
| 4.1.3 In vivo infrared thermal imaging | 第60页 |
| 4.1.4 In vivo& ex vivo fluorescence and photoacoustic imaging | 第60-61页 |
| 4.1.5 In vivo phototoxicity studies | 第61页 |
| 4.2 Results and discussions | 第61-67页 |
| 4.2.1 In vivo thermal imaging | 第61-62页 |
| 4.2.2 Fluorescence biodistribution and photoacoustic tomography | 第62-63页 |
| 4.2.3 Therapeutic efficacy study | 第63-64页 |
| 4.2.4 Histopathological studies | 第64-67页 |
| Chapter5 Conclusions and outlook of AuNRs-Ce6-MSNRs | 第67-71页 |
| 5.1 Conclusions | 第67-68页 |
| 5.2 Outlook | 第68-71页 |
| Chapter6 The preparation and characterization of DOX@GdMSNs-ICG-TSLs | 第71-81页 |
| 6.1 Experimental sections | 第71-75页 |
| 6.1.1 Experimental agents and instruments | 第71-73页 |
| 6.1.1.1 Main agents used in experiments | 第71-72页 |
| 6.1.1.2 Experimental instruments | 第72-73页 |
| 6.1.2 Preparation of DOX@GdMSNs-ICG-TSLs | 第73-74页 |
| 6.1.3 Characterization of DOX@GdMSNs-ICG-TSLs | 第74页 |
| 6.1.4 In vitro photothermal effect | 第74页 |
| 6.1.5 In vitro photodynamic effect | 第74-75页 |
| 6.1.6 In vitro release experiment | 第75页 |
| 6.2 Results and discussions | 第75-81页 |
| 6.2.1 Preparation and morphological appearance of DOX@GdMSNs-ICG-TSLs | 第75-76页 |
| 6.2.2 UV-Vis,IR spectra,XRD,BET and line graph of size distribution | 第76-78页 |
| 6.2.3 In vitro Efficacy Evaluation | 第78-81页 |
| Chapter7 In vitro cell experiments of AuNRs-Ce6-MSNRs | 第81-89页 |
| 7.1 Experimental sections | 第81-84页 |
| 7.1.1 Experimental agents and instruments | 第81-83页 |
| 7.1.1.1 Main agents used in experiments | 第81-82页 |
| 7.1.1.2 Experimental instruments | 第82-83页 |
| 7.1.2 In vitro cytotoxicity | 第83-84页 |
| 7.1.3 In vitro cellular uptake and SOG | 第84页 |
| 7.2 Results and discussions | 第84-89页 |
| 7.2.1 Cellular cytotoxicity assay | 第84-86页 |
| 7.2.2 Cellular uptake and intercellular ROS detection | 第86-89页 |
| Chapter8 In vivo anti-tumor effect of DOX@GdMSNs-ICG-TSLs | 第89-99页 |
| 8.1 Experimental sections | 第89-92页 |
| 8.1.1 Experimental agents and instruments | 第89-90页 |
| 8.1.1.1 Main agents used in experiments | 第89页 |
| 8.1.1.2 Experimental instruments | 第89-90页 |
| 8.1.2 Mouse models of tumor | 第90页 |
| 8.1.3 In vivo infrared thermal imaging | 第90页 |
| 8.1.4 Near infrared fluorescence,photoacoustic and magnetic resonance imaging | 第90-91页 |
| 8.1.5 In vivo antitumor efficiency | 第91-92页 |
| 8.2 Results and discussions | 第92-99页 |
| 8.2.1 In vivo thermal imaging | 第92-93页 |
| 8.2.2 In vivo NIRF,PA and MR Imaging | 第93-96页 |
| 8.2.3 Therapeutic efficacy study | 第96-97页 |
| 8.2.4 Histopathological studies | 第97-99页 |
| Chapter9 Conclusions and outlook of DOX@GdMSNs-ICG-TSLs | 第99-103页 |
| 9.1 Conclusions | 第99-101页 |
| 9.2 Outlook | 第101-103页 |
| References | 第103-119页 |
| Appendix A | 第119-121页 |
| Notes on publications and participation in scientific research | 第121-123页 |
| Acknowledgement | 第123页 |
