| Acknowledgement | 第1-9页 |
| Abstract | 第9-11页 |
| List of Figures | 第11-13页 |
| Minireview | 第13-27页 |
| Introduction | 第27-30页 |
| Chapter 1 Effects of Sal and Sai A on oxygen radical induced mitochondrial damage | 第30-47页 |
| Summary | 第30页 |
| Introduction | 第30-31页 |
| Materials and Methods | 第31-34页 |
| Results | 第34-42页 |
| 1. Effects of Sal and Sai A on rat heart and liver mitochondrial lipid peroxidation and loss of ATPase activity | 第34-37页 |
| 2. Effects of Sal and Sai A on mitochondrial swelling induced by lipid peroxidation | 第37页 |
| 3. Effects of Sal and Sai A on fluidity of mitochondrial membrane | 第37页 |
| 4. Effects of Sal on oxidative injury to ultrastracture of rat heart mitochondria | 第37-42页 |
| Discussion | 第42-45页 |
| References | 第45-47页 |
| Chapter 2 Oxygen radical scavenging activity of Sal and Sai A | 第47-67页 |
| Summary | 第47页 |
| Introduction | 第47-48页 |
| Materials and Methods | 第48-51页 |
| Results | 第51-59页 |
| 1. Active oxygen radical-scavenging effects of Sal and Sin A in Neu during respiratory burst | 第51页 |
| 2. Effects of Sal and Sin A on oxygen consumption of Neu during respiratory burst stimulated by PMA | 第51-53页 |
| 3. Sal and Sin A scavenging OH~· in Fenton reaction | 第53页 |
| 4. Sal and Sin A scavenging O_2~·in xanthine-xanthine oxidase system | 第53-57页 |
| 5. Sal and Sin A scavenging O_2~· in uv-irradiation of riboflavin system | 第57页 |
| 6. Hydroxyl radical scavenging effect of Sai A | 第57-59页 |
| 7. O_2~·scavenging effect of Sai A | 第59页 |
| 8. Effect of Sai A on xanthine oxidase activity | 第59页 |
| Discussion | 第59-65页 |
| References | 第65-67页 |
| Chapter 3 Effects of Sal and Sai A on adriamycin induced mitochondrial damage | 第67-87页 |
| Summary | 第67页 |
| Introduction | 第67-68页 |
| Materials and Methods | 第68-69页 |
| Results | 第69-82页 |
| 1. Effects of Sal and Sai A on ADM induced mitochondrial lipid peroxidation | 第69-72页 |
| 2. Effects of Sal on adriamycin induced rat heart mitochondrial ultrastructural damage | 第72页 |
| 3. Effects of Sal and Sai A on ADM induced mitochondrial membrane rigidification | 第72-75页 |
| 4. Effects of Sal and Sai A on ADM semiquinone radicals | 第75页 |
| 5. Effects of Sal and Sai A on AQ~·generated OH~· | 第75-82页 |
| Discussion | 第82-84页 |
| References | 第84-87页 |
| Chapter 4 Effects of Sal and Sai A on the antitumor activity of adriamycin | 第87-100页 |
| Summary | 第87页 |
| Introduction | 第87-88页 |
| Materials and Methods | 第88-90页 |
| Results | 第90-94页 |
| 1. Effects of Sal and Sai A on the antitumor activity of adriamycin in vivo | 第90页 |
| 2. Effects of Sal and Sai A on the antitumor activity of adriamycin in vitro | 第90页 |
| 3. Effects of Sal on ADM-induced inhibition of 3~H-TdR incorporation in vitro | 第90-94页 |
| 4. Effects of Sal and Sai A on adriamycin-iron mediated DNA degradation | 第94页 |
| Discussion | 第94-100页 |
| References | 第100页 |
