| 摘要 | 第3-4页 |
| abstract | 第4页 |
| CHAPTER1.INTRODUCTION | 第11-53页 |
| 1.1 General Introduction | 第11-13页 |
| 1.2 Brief overview of Nanotechnology and drug delivery | 第13-15页 |
| 1.3 Review of polymeric nanoparticles as drug delivery systems | 第15-20页 |
| 1.4 Factors affecting polymeric nanoparticles performance in drug delivery system | 第20-22页 |
| 1.5 Preparation methods of polymeric nanoparticles | 第22-41页 |
| 1.5.1 Polymeric NPs obtained from deposition of performed polymer | 第22-28页 |
| 1.5.2 Polymeric NPs obtained from polymerization method | 第28-41页 |
| 1.6 Characterization of polymeric nanoparticles in DDS | 第41-45页 |
| 1.6.1 Particle size and morphology | 第41-42页 |
| 1.6.2 Particle surface charge and stability | 第42页 |
| 1.6.3 Physical and chemical modifications | 第42-43页 |
| 1.6.4 Drug loading | 第43页 |
| 1.6.5 Drug release | 第43-45页 |
| 1.7 Applications of polymeric nanoparticles | 第45-51页 |
| 1.7.1 Oral delivery | 第45-46页 |
| 1.7.2 Tumor/cancer therapy | 第46-48页 |
| 1.7.3 Gene delivery | 第48-51页 |
| 1.8 Proposals of the subject | 第51-53页 |
| CHAPTER2.EXPERIMENTAL SECTION | 第53-59页 |
| 2.1 Materials | 第53页 |
| 2.2 Synthesis of Polymers | 第53-56页 |
| 2.2.1 Synthesis of diblock copolymer(PEG-PCL) | 第53-54页 |
| 2.2.2 Synthesis of triblock copolymer(PCL-PEG-PCL) | 第54页 |
| 2.2.3 Synthesis of umbrella-shaped copolymer(PEG3-Ph-PCL) | 第54-56页 |
| 2.3 Physicochemical characterization of block copolymers | 第56-57页 |
| 2.3.1 ~1H-NMR | 第56页 |
| 2.3.2 FTIR | 第56页 |
| 2.3.3 UV-vis | 第56页 |
| 2.3.4 Molecular weight measurements | 第56-57页 |
| 2.3.5 Block copolymer Solubility measurements | 第57页 |
| 2.4 Preparation of self-assembled polymeric NPs | 第57页 |
| 2.5 Physicochemical characterization of the polymeric NPs | 第57-58页 |
| 2.5.1 Size measurements | 第57页 |
| 2.5.2 Morphology and structure measurements | 第57-58页 |
| 2.6 Measurement of fluorescence spectroscopy(pyrene) | 第58-59页 |
| CHAPTER3.EXPERIMENTAL RESULTS AND DISCUSSION | 第59-85页 |
| 3.1 Synthesis and Characterization of block copolymers | 第59-85页 |
| 3.1.1 Diblock mPEG-PCL and triblock PCL-PEG-PCL copolymers | 第59-66页 |
| 3.1.2 Umbrella-shaped mPEG3-Ph-PCL copolymers | 第66-73页 |
| 3.1.3 Molecular weight and molecular weight distribution | 第73-75页 |
| 3.1.4 Water dispersibility of block copolymers | 第75-76页 |
| 3.1.5 Critical micelle concentration of block copolymers | 第76-79页 |
| 3.1.6 Self-assembly behavior of block copolymers | 第79-85页 |
| CHAPTER4.CONCLUSIONS AND RECOMMENDATIONS | 第85-87页 |
| REFERENCES | 第87-107页 |
| PUBLISHED PAPERS AND PARTICIPATION IN SCIENTIFIC RESEARCH PAPERS | 第107-109页 |
| ACKNOWLEDGEMENTS | 第109页 |
