| 中文摘要 | 第1-10页 |
| ABSTRACT | 第10-13页 |
| Chapter 1 New progress in Azole Compounds as Antibacterial and Antifungal Agents | 第13-51页 |
| 本章详细中文摘要 | 第13-14页 |
| ·Introduction | 第14-15页 |
| ·Oxazoles as antibacterial and antifungal agents | 第15-19页 |
| ·Oxazole compounds as antibacterial and antifungal agents | 第15-16页 |
| ·Oxadiazole compounds as antibacterial and antifungal agents | 第16-18页 |
| ·Oxazolidone compounds as antibacterial and antifungal agents | 第18-19页 |
| ·Imidazoles as antibacterial and antifungal agents | 第19-23页 |
| ·Imidazole compounds as antibacterial agents | 第20-22页 |
| ·Imidazole compounds as antifungal agents | 第22-23页 |
| ·Benzimidazoles as antibacterial and antifungal agents | 第23-27页 |
| ·Benzimidazole compounds as antibacterial agents | 第23-26页 |
| ·Benzimidazole compounds as antifungal agents | 第26-27页 |
| ·Triazoles as antibacterial and antifungal agents | 第27-32页 |
| ·Triazole compounds as antibacterial agents | 第27-30页 |
| ·Triazole compounds as antifungal agents | 第30-32页 |
| ·Benzotriazoles as antibacterial and antifungal agents | 第32页 |
| ·Pyrazoles as antibacterial and antifungal agents | 第32-35页 |
| ·Pyrazole compounds as antibacterial agents | 第33-34页 |
| ·Pyrazole compounds as antifungal agents | 第34-35页 |
| ·Thiazoles as antibacterial and antifungal agents | 第35-38页 |
| ·2-Aminothiazole compounds as antibacterial and antifungal agents | 第35-37页 |
| ·Thiazolidinone compounds as antibacterial and antifungal agents | 第37页 |
| ·Thiazole-based metal complexes as antibacterial and antifungal agents | 第37-38页 |
| ·Carbazoles as antibacterial and antifungal agents | 第38-39页 |
| ·Tetrazoles as antibacterial and antifungal agents | 第39-40页 |
| ·Conclusions and outlooks | 第40-41页 |
| ·Strategy of this thesis | 第41-42页 |
| References | 第42-51页 |
| Chapter 2 Design and synthesis of novel benzimidazole type of fluconazole analogues and relational antimicrobial study | 第51-115页 |
| 本章详细中文摘要 | 第51-55页 |
| ·Introduction | 第55-59页 |
| ·Results and discussion | 第59-81页 |
| ·Chemistry | 第59-61页 |
| ·Analyses of spectra | 第61-74页 |
| ·Biological activity | 第74-81页 |
| ·Conclusion | 第81-82页 |
| ·Experimental | 第82-103页 |
| ·General methods | 第82-102页 |
| ·Antibacterial and antifungal assays | 第102-103页 |
| References | 第103-109页 |
| APPENDIX Ⅰ | 第109-115页 |
| Chapter 3 Design and synthesis of novel benzimidazole derivatives and relational antimicrobial study | 第115-165页 |
| 本章详细中文摘要 | 第115-119页 |
| ·Introduction | 第119-121页 |
| ·Results and discussion | 第121-144页 |
| ·Chemistry | 第121-123页 |
| ·Analyses of spectra | 第123-134页 |
| ·Biological activity | 第134-141页 |
| ·Interaction with calf thymus DNA | 第141-144页 |
| ·Conclusion | 第144-145页 |
| ·Experimental | 第145-158页 |
| ·General methods | 第145-158页 |
| ·Antibacterial and antifungal assays | 第158页 |
| References | 第158-163页 |
| APPENDIX Ⅱ | 第163-165页 |
| Chapter 4 A unique one-pot reaction via C-C cleavage from aminomethylene benzimidazoles to access benzimidazolones with wide potentiality | 第165-233页 |
| 本章详细中文摘要 | 第165-167页 |
| ·Introduction | 第167-168页 |
| ·Results and discussion | 第168-176页 |
| ·Proposal mechanism and optimisation of reaction conditions for the preparation of benzimidazolones | 第168-174页 |
| ·Biological activity | 第174-176页 |
| ·Conclusion | 第176-177页 |
| ·Experimental | 第177-198页 |
| ·General methods | 第177-198页 |
| ·Antibacterial and antifungal assays | 第198页 |
| References | 第198-331页 |
| APPENDIX Ⅲ | 第331-233页 |
| Chapter 5 Synthesis of novel sulfonamide azoles via C-N cleavage of sulfonamides by azole ring and relational antimicrobial study | 第233-339页 |
| 本章详细中文摘要 | 第233-236页 |
| ·Introduction | 第236-238页 |
| ·Results and discussion | 第238-301页 |
| ·Chemistry | 第238-241页 |
| ·Structural elucidation of compound V-8a | 第241-242页 |
| ·Screening of the optimal reaction conditions for compound V-8a | 第242页 |
| ·Analyses of spectra | 第242-285页 |
| ·Biological activity | 第285-291页 |
| ·Interaction with calf thymus DNA | 第291-295页 |
| ·Interactions of compound V-9d with HSA | 第295-301页 |
| ·Conclusion | 第301-302页 |
| ·Experimental | 第302-325页 |
| ·General methods | 第302-325页 |
| ·Ant-bacterial and antifungal assays | 第325页 |
| References | 第325-331页 |
| APPENDIX Ⅳ | 第331-339页 |
| Conclusions and outlooks(结论与展望) | 第339-343页 |
| Financial Supports(基金支持) | 第343-345页 |
| Acknowledgments(致谢) | 第345-347页 |
| A brief introduction to the author(作者简介) | 第347-349页 |
| Achievements(攻读博士学位期间研究成果) | 第349-351页 |
