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环境友好型无溶剂法制备键合硅胶色谱固定相

摘要第3-8页
ABSTRACT第8-9页
Chapter1 Literature reviews第13-43页
    Introduction第13页
    1.1 Drug analysis in drug development第13-15页
        1.1.1 Process of drug research第13-14页
        1.1.2 Methods of drug analysis第14-15页
    1.2 High performance liquid chromatography第15-19页
        1.2.1 Reversed phase liquid chromatography第15-16页
        1.2.2 Normal phase liquid chromatography第16页
        1.2.3 Hydrophilic interaction liquid chromatography第16页
        1.2.4 Ion exchange liquid chromatography第16-17页
        1.2.5 Molecular exclusion chromatography第17页
        1.2.6 Mixed-mode liquid chromatography第17-19页
    1.3 Supports of HPLC packings第19-21页
        1.3.1 Inorganic supports第19-20页
        1.3.2 Organic supports第20页
        1.3.3 Organic-inorganic hybrid supports第20-21页
    1.4 Preparation of chemically bonded silica stationary phase第21-26页
        1.4.1 Organic solvent methods第21-22页
        1.4.2 Supercritical fluid methods第22-23页
        1.4.3 Fluidised-bed reactor methods第23-24页
        1.4.4 Vapor deposition methods第24-25页
        1.4.5 Click chemistry第25-26页
    1.5 Characterization and evaluation第26-35页
        1.5.1 Nitrogen adsorption isotherm第27-31页
        1.5.2 Infrared spectroscopy第31-32页
        1.5.3 Nuclear magnetic resonance technique第32页
        1.5.4 Elemental analysis第32-33页
        1.5.5 Chromatographic evaluation第33-35页
    1.6 Retention mechanism第35-39页
        1.6.1 Linear solvation energy relationships第36-38页
        1.6.2 Multiple sites model第38-39页
    1.7 Objectives第39-43页
Chapter2 Experimental第43-57页
    2.1 Materials and instruments第43-46页
        2.1.1 Materials第43-45页
        2.1.2 Instruments第45-46页
    2.2 Preparation and characterization of C_(18) reversed-phase packing第46-50页
        2.2.1 Preparation第46-47页
        2.2.2 Optimization of preparation conditions第47-48页
        2.2.3 Preparation of C_(18) reversed phase by different methods第48-49页
        2.2.4 Characterization第49页
        2.2.5 Evaluation and chromatographic conditions第49-50页
    2.3 Preparation and characterization of thioether-embedded cyano stationary phase第50-53页
        2.3.1 Preparation第50-51页
        2.3.2 Characterization第51页
        2.3.3 Chromatographic evaluation第51-52页
        2.3.4 Hydrolytic stability第52页
        2.3.5 Chromatographic conditions第52-53页
    2.4 Retention mechanisms on thioether-embedded cyano stationary phase第53-57页
        2.4.1 Tanaka tests第53-54页
        2.4.2 Linear solvation energy relationships第54页
        2.4.3 Multiple sites model第54-57页
Chapter3 Preparation of C_(18) reversed-phase packing第57-73页
    Introduction第57-58页
    3.1 Optimized conditions第58-65页
        3.1.1 Effect of impregnation solvents第58-60页
        3.1.2 Effect of impregnation time第60-61页
        3.1.3 Effect of octadecyl silane amount第61页
        3.1.4 Effect of octadecyl silane types第61-65页
    3.2 Preparation of C_(18) reversed phase第65-71页
        3.2.1 Synthesis and characterization第65-68页
        3.2.2 Chromatographic evaluation第68-69页
        3.2.3 Reproducibility第69-71页
    3.3 Conclusions第71-73页
Chapter4 Preparation of thiol-embedded cyano packing第73-85页
    Introduction第73-74页
    4.1 Synthesis and characterization第74-76页
    4.2 Chromatographic evaluation第76-81页
        4.2.1 Retention characteristics under RPLC mode第76-78页
        4.2.2 Retention characteristics under HILIC mode第78-80页
        4.2.3 Retention characteristics under RPLC/HILIC mode第80-81页
    4.3 Accelerated stability test第81-82页
    4.4 Conclusions第82-85页
Chapter5 Retention mechanism of thiol-embedded cyano bonded packing第85-99页
    Introduction第85-86页
    5.1 Tanaka tests第86-89页
    5.2 Linear solvation energy relationships第89-92页
    5.3 Multiple sites model第92-97页
        5.3.1 Effect of eluent pH on retention第92-94页
        5.3.2 Effect of ionic strength on retention第94-95页
        5.3.3 Effect of solvent strength on retention第95-97页
    5.4 Conclusions第97-99页
Chapter6 Conclusions and outlooks第99-101页
    6.1 Conclusions第99-100页
    6.2 Outlooks第100-101页
References第101-111页
Notes on publications and participation in scientific research第111-113页
Acknowledgements第113页

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