| 中文摘要 | 第3-7页 |
| ABSTRACT | 第7页 |
| Chapter 1 Research background | 第10-30页 |
| 1.1 Introduction | 第10页 |
| 1.2 The compounds of 2H-azirine existing in nature | 第10-11页 |
| 1.3 The methods of synthesizing 2H-azirines | 第11-16页 |
| 1.3.1 The classic Neber reaction （route a） | 第11-12页 |
| 1.3.2 The azirination of vinyl azides through pyrolysis or photolysis (routeb) | 第12-13页 |
| 1.3.3 Through intramolecular elimination or swern oxidation of aziridinederivatives. (route c) | 第13页 |
| 1.3.4 Intramolecular rearrangement of isoxazole or phosphoisoxazole (routed) | 第13-15页 |
| 1.3.5 Intramolecular reactions of carbene with nitriles or nitrene withalkynes. (route e and f) | 第15页 |
| 1.3.6 Cyclization of β-mono-substituted enamines under the reaction ofhypervalent iodine oxidants. (route g) | 第15-16页 |
| 1.3.7 Wolff rearrangement of α-diazo oxime ethers.(route h) | 第16页 |
| 1.4 Application of 2H-azirine compounds in organic synthesis | 第16-23页 |
| 1.4.1 Reactions in which N atoms participates | 第17-18页 |
| 1.4.2 Reactions in which N-C2 participates | 第18-20页 |
| 1.4.3 Reactions in which C2-C3 participates | 第20-21页 |
| 1.4.4 Reactions in which N-C3 participates | 第21-23页 |
| 1.5 Important fluorinated drugs | 第23-24页 |
| 1.6 Fluorination reaction mediated by hypervalent iodine reagents | 第24-28页 |
| Conclusion | 第28-30页 |
| Chapter 2 Project design | 第30-34页 |
| 2.1 Introduction | 第30页 |
| 2.2 Project design and feasibility analysis | 第30-32页 |
| 2.3 Research contents | 第32-34页 |
| Chapter 3 Results and discussions | 第34-42页 |
| 3.1 Introduction | 第34页 |
| 3.2 The optimization of the reaction conditions | 第34-36页 |
| 3.3 Investigation of the scope of substrate application | 第36-38页 |
| 3.4 Application of the product for further transformation | 第38页 |
| 3.5 Reaction mechanism | 第38-40页 |
| 3.6 Summary | 第40-42页 |
| Chapter 4 Experimental reagents and instruments | 第42-46页 |
| 4.1 Source and specification of reagents | 第42-43页 |
| 4.2 Analytical instruments and methods | 第43-46页 |
| Chapter 5 Experimental sections | 第46-50页 |
| 5.1 Preparation of Substrates | 第46-49页 |
| 5.2 The Preparation of Iodosylbenzene | 第49页 |
| 5.3 Preparation of Fluorinated 2H-Azirine 2 | 第49-50页 |
| Chapter 6 Structure characterization of the prepared compounds | 第50-70页 |
| 6.1 Spectral Data of Substrates | 第50-59页 |
| 6.2 Spectral Data of Products | 第59-70页 |
| References | 第70-76页 |
| Notes on publications and participation in scientific research | 第76-78页 |
| Appendix 1: Copies of ~1H-NMR,~(13)C-NMR and ~(19)F-NMR Spectra | 第78-136页 |
| Appendix 2: X-ray Structure and Data of 2d | 第136-140页 |
| Acknowledgement | 第140页 |
