| Abbreviation | 第7-8页 |
| 中文摘要 | 第8-13页 |
| ABSTRACT | 第13-17页 |
| 1 Introduction | 第18-34页 |
| 1.1 Integrin receptors | 第18-19页 |
| 1.2 Mechanism of integrins regulate tumour angiogenesis promote metastasis | 第19-30页 |
| 1.2.1 Integrins regulate tumor angiogenesis | 第20-21页 |
| 1.2.2 Integrin enhance cell survival or apoptosis | 第21-24页 |
| 1.2.3 Integrins control the host cells response to cancer | 第24-25页 |
| 1.2.4 Integrins cooperate with oncogenes for tumor growth and invasion | 第25-26页 |
| 1.2.5 Integrins corss talk with growth factors | 第26-30页 |
| 1.3 Design anti-cancer therapeutic agents to target av integrins | 第30-33页 |
| 1.4 Additional integrin αv antagonists | 第33-34页 |
| 2 Integrin αvβ5 as a biomarker for NSCLC metastasis and overall survival | 第34-54页 |
| 2.1 Material and Method | 第35-41页 |
| 2.1.1 Formalin Fixed Paraffin Embedded(FFPE)tissue samples | 第35-37页 |
| 2.1.2 Reagents and materials | 第37-38页 |
| 2.1.3 Instruments | 第38页 |
| 2.1.4 Methods | 第38-40页 |
| 2.1.5 Results evaluation | 第40-41页 |
| 2.1.6 Statistical analysis | 第41页 |
| 2.2 Results | 第41-54页 |
| 2.2.1 Patient clinical information and integrin αvβ5 expression levels | 第41-43页 |
| 2.2.2 Integrin αvβ5 IHC staining and Clinicopathological features | 第43-49页 |
| 2.2.3 Integrin expression level comparison in cancer tissue and normal tissue | 第49-51页 |
| 2.2.4 Integrin expession level relates to overall survival | 第51-54页 |
| 3 Integrin αvβ5 cross talk with EGFR in non-small cell lung cancer | 第54-74页 |
| 3.1 Material and Method | 第55-67页 |
| 3.1.1 Extract cancer tissue from the FFPE cutting slides | 第55页 |
| 3.1.2 DNA extraction | 第55-58页 |
| 3.1.3 Quantifying DNA | 第58页 |
| 3.1.4 PCR amplification | 第58-59页 |
| 3.1.5 Sequencing(ABI3730) | 第59-67页 |
| 3.1.6 Statistical analysis | 第67页 |
| 3.2 Results | 第67-74页 |
| 3.2.1 Patient clinical information and EGFR mutation positive and negative ratio | 第67-69页 |
| 3.2.2 3.2.2 EGFR positive and negative not relates to overall survival | 第69-71页 |
| 3.2.3 Combination biomarkers and therapies | 第71-74页 |
| 4 summary | 第74-76页 |
| References | 第76-88页 |
| Publications during study | 第88-89页 |
| Acknowledgement | 第89-90页 |
