| Abstract | 第5页 |
| 摘要 | 第6-7页 |
| ABBREVIATIONS | 第7-10页 |
| CHAPTER 1: GENERAL INTRODUCTION TO THE ASSOCIATION OF AMBIENT PM2.5 EXPOSURE AND INCREASED RISK OF COPD | 第10-21页 |
| 1. Background | 第10-11页 |
| 2. Epidemiology of chronic obstructive pulmonary disease | 第11-16页 |
| 3. Factors determining the susceptibility of the population exposed to PM2.5 | 第16-18页 |
| 4. Air quality guidelines and standards at a glance | 第18-19页 |
| 5. Current issues on the association of air pollution and adverse health effects | 第19-21页 |
| CHAPTER 2: LITTERATURE REVIEW | 第21-28页 |
| 2.1 Evidence of association between PM2.5 exposure and COPD | 第21-25页 |
| 2.2. In vivo and in vitro experiments of the health effects associated with PM2.5 exposure | 第25-28页 |
| CHAPTER 3: ASSOCIATIONS OF SHORT TERM EXPOSURE TO PM2.5 ANDINCREASED COPD HOSPITALIZATIONS: A SYSTEMATIC REVIEW AND META-ANALYSIS | 第28-36页 |
| 3.1. Introduction | 第28页 |
| 3.2. Methods and materials | 第28-29页 |
| 3.3 Results | 第29-36页 |
| 3.3.1 COPD hospitalizations and short-term exposure to PM2.5 | 第32-33页 |
| 3.3.2. Publication bias | 第33-34页 |
| 3.3.3. Discussion | 第34-36页 |
| CHAPTER 4: ASSOCIATION BETWEEN INFLAMMATORY BIOMARKERS ANDCOPD: A PANEL STUDY | 第36-42页 |
| 4.1. Introduction | 第36页 |
| 4.2. Methods and materials | 第36-38页 |
| 4.3. Results and discussion | 第38-42页 |
| Conclusion | 第42-43页 |
| REFERENCES | 第43-50页 |
| REVIEW: FINE PARTICULATE MATTER AND RESPIRATORY DISEASES | 第50-59页 |
| 1. Introduction | 第50-51页 |
| 2. Toxic effects of particulate matter on respiratory diseases | 第51-52页 |
| 3. Fine particulate matter and Asthma | 第52-54页 |
| 4. Fine particulate matter and chronic obstructive pulmonary disease | 第54-55页 |
| 5. Fine particulate matter and lung cancer | 第55页 |
| 6. Prevention and control | 第55-56页 |
| REFERENCES | 第56-59页 |
| Acknowledgements | 第59页 |
