| 摘要 | 第1-7页 |
| Abstract | 第7-10页 |
| Chapter 1 Introduction | 第10-15页 |
| ·Transcription and Eukaryotic Promoter | 第10-11页 |
| ·Significance of Promoter Prediction | 第11-12页 |
| ·Outline of this Thesis | 第12-15页 |
| Chapter 2 Literature Review | 第15-28页 |
| ·Important Promoter Features | 第15-19页 |
| ·Sequence Signal Features | 第15-17页 |
| ·Sequence Context Features | 第17页 |
| ·Summary of Features Used in Existing Promoter Prediction Models | 第17-19页 |
| ·Review of Promoter Feature Extraction and Selection Algorithms | 第19-25页 |
| ·Sequence Feature Extraction Algorithms | 第20-23页 |
| ·Sequence Feature Selection Algorithms | 第23-25页 |
| ·Review of Modeling and Classification Methodology. | 第25-28页 |
| ·Introduction of modeling and classification methodology | 第25-26页 |
| ·Summary of modeling and classification methodology used in existing promoter prediction models | 第26-28页 |
| Chapter 3 Application of Principal Component Analysis and Artificial Neural Network to Promoter Feature Selection | 第28-45页 |
| ·Principal Component Analysis. | 第28-33页 |
| ·Theoretical background | 第28-32页 |
| ·Bioinformatics applications of PCA | 第32-33页 |
| ·Artificial Neural Network and Training Method | 第33-37页 |
| ·Artificial Neural Network and Backpropagation Learning Method | 第33-37页 |
| ·Holdout Validation Training Method. | 第37页 |
| ·Features Selection Based on PCA. | 第37-45页 |
| ·Feature Matrix Generation | 第38-40页 |
| ·Feature Selection Based on PCA | 第40-43页 |
| ·Conclusion | 第43-45页 |
| Chapter 4 Human Promoter Recognition Network | 第45-59页 |
| ·Overview of Human Promoter Prediction Network | 第45-47页 |
| ·Implementations of Sub-Modules | 第47-56页 |
| ·Feature Vector Creation and PCA Modules | 第47-49页 |
| ·Classifiers for Promoter and Non-Promoter Sequences | 第49-55页 |
| ·CpG islands module | 第55-56页 |
| ·Data Processing and Prediction of TSS | 第56页 |
| ·Performance Evaluation of Scheme I and Scheme II | 第56-59页 |
| Chapter 5 Results and Discussion | 第59-65页 |
| ·Test Results and Discussion | 第59-64页 |
| ·Future Work | 第64-65页 |
| Conclusion | 第65-67页 |
| 参考文献 | 第67-72页 |
| 攻读学位期间发表的学术论文 | 第72-74页 |
| 致谢 | 第74-75页 |
| 个人简历 | 第75页 |
