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儿童期创伤对抑郁症患者糖皮质激素受体1F启动子区域CpG岛DNA甲基化状态的影响

Abstract第4-6页
摘要第7-13页
Content第13-15页
Abbreviations第15-18页
Chapter 1 INTRODUCTION第18-22页
    1.1 Background第18-19页
    1.2 Statement of the Problem第19-20页
    1.3 Aim of the Study第20页
    1.4 Objectives第20页
    1.5 Significance of the Study第20页
    1.6 Definition of Terminologies第20页
    1.7 Organization of Work第20-22页
Chapter 2 LITERATURE REVIEW第22-43页
    2.1 What is Major Depressive Disorder?第22页
    2.2 The Importance of Genetics in Depression第22-23页
    2.3 What is Epigenetics?第23-25页
    2.4 Mechanisms of Epigenetic Regulation in the Genome第25-26页
    2.5 How does Early Life Adversity shape the HPA Axis?第26页
    2.6 The Basic Anatomy of the HPA Axis第26-28页
    2.7 Creating a Model for Early Life Experiences第28-32页
    2.8 Defining DNA Methylation Status of the Glucocorticoid Receptor第32-33页
    2.9 Role of the CpG Islands in the DNA Methylation第33页
    2.10 Structure of the NR3C1 Gene第33-40页
    2.11 What is Childhood Trauma?第40-43页
Chapter 3 MATERIALS AND METHODS第43-54页
    3.1 Study Population第43-44页
        3.1.1 Setting第43页
        3.1.2 Participants第43页
        3.1.3 Inclusion Criteria第43-44页
        3.1.4 Exclusion Criteria第44页
        3.1.5 Sample size第44页
    3.2 Methods第44-53页
        3.2.1 Study Design第44页
        3.2.2 Interviewing Techniques第44-45页
        3.2.3 Instrument for Data Collection第45页
        3.2.4 Measures第45-46页
        3.2.5 Blood Samples第46-47页
        3.2.6 Identification of the Glucocorticoid Receptor Promoter Exon IF and 13CpG Islands第47-48页
        3.2.7 NR3C1 Promoter Methylation Sequencing第48页
        3.2.8 Procedure for DNA Analysis and Identification of the 13 CpG Islands in thePromoter Region Exon IF第48-53页
    3.3 Data Analysis第53-54页
Chapter 4 RESULTS第54-69页
    4.1 Demographic Characteristics of the Participants第54-60页
        4.1.1 Distribution of Study Groups第54页
        4.1.2 Expressions of the Study Groups using the Child Trauma Questionnaire第54页
        4.1.3 Demographics and Clinical Characteristics of Participants (n=60)第54-56页
        4.1.4 The Distribution of the Participants based on Gender第56页
        4.1.5 Distribution of Subjects based on Age第56-57页
        4.1.6 Family History of Participants With or Without Mental Disease第57-58页
        4.1.7 Distribution of Participants According to Medication History第58页
        4.1.8 CTQ scores and Distribution Healthy Controls第58-59页
        4.1.9 CTQ Test Score and Distribution of the Depressed Patients Without ChildhoodTrauma第59-60页
        4.1.10 CTQ Scores of Depressed Patients With Childhood Trauma第60页
    4.2 Expression of the CpG Islands第60-64页
        4.2.1 The Average Level of DNA Methylation of the 13 CpG Islands Among theThree Groups第63-64页
    4.3 Analysis of DNA Methylation of the 13 CpG Sites第64-69页
        4.3.1 Major Depressive Disorder Including all Depressive Patients (MDD) Comparedto Healthy Controls (HC)第64-65页
        4.3.2 Depressive Patients Without Childhood Trauma (NTD) Compared toHealthy Controls Without Childhood Trauma (HC)第65-66页
        4.3.3 DNA Methylation Status of the Depressed Patients With ChildhoodMaltreatment and Healthy Controls第66页
        4.3.4 Statistical Correlation of DNA Methylation Status for Both Groups ofDepressed Patients第66-67页
        4.3.5 The Three Different Methylation Levels at CpG 7 and 8 in All Groups第67-69页
Chapter 5 DISCUSSIONS AND CONCLUSIONS第69-74页
    5.1. Discussions第69-72页
        5.1.1 Main findings第69页
        5.1.2 MDD and the 13 CpG sites DNA Methylation of the Exon 1F第69-70页
        5.1.3 Childhood Trauma and Exon 1F第70-72页
        5.1.4 Limitations第72页
    5.2. Conclusions第72-74页
References第74-80页
Acknowledgements第80页

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