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基于肝素分子固定与原位催化释放NO的仿生支架表面构筑

摘要第6-8页
Abstract第8-9页
CHAPTER 1 INTRODUCTION第13-42页
    1.1 CORONARY ARTERY DISEASE THERAPY第13-23页
        1.1.1 Cardiovascular disease, atherosclerosis第13-15页
        1.1.2 Coronary artery bypass graft surgery and vascular grafts第15-17页
        1.1.3 Percutaneous coronary intervention and coronary artery stents第17-23页
    1.2 ENDOTHELIUM FUNCTION MIMICKING SURFACE MODIFICATION第23-32页
        1.2.1 ECs functions第23-26页
        1.2.2 Heparin based surface modification第26-29页
        1.2.3 Nitric oxide based surface modification第29-32页
    1.3 PROGRESS OF POLYDOPAMINE COATING IN BIOMEDICAL FIELD第32-38页
        1.3.1 Coating mechanism, structure and preparation第32-36页
        1.3.2 Applications in biomedical field第36-38页
    1.4 SIGNIFICANCE AND OBJECTIVES,DISSERTATION LAYOUT AND TECHNICAL ROUTE第38-42页
        1.4.1 Significance and objectives第38-39页
        1.4.2 Dissertation layout第39-41页
        1.4.3 Technical route第41-42页
CHAPTER 2 MUSSEL-INSPIRED CHEMISTRY FOR BIOCOMPATIBLE ANDFUNCTIONAL COATINGS RICH IN AMINE GROUPS第42-69页
    2.1 INTRODUCTION第42-43页
    2.2 EXPERIMENTAL SECTION第43-47页
        2.2.1 Preparation of the PDAM/HD copolymer coating第43页
        2.2.2 Characterization of the PDAM/HD copolymer coating第43-45页
        2.2.3 HUVEC culture,staining and proliferation第45页
        2.2.4 Macrophages evaluation and in vivo tissue response test第45-46页
        2.2.5 Heparin conjugation and quantitative determination第46-47页
        2.2.6 APTT assay第47页
        2.2.7 Statistical analysis第47页
    2.3 RESULTS ANALYSIS第47-63页
        2.3.1 FTIR,amine group density and thickness of PDAM/HD coating第47-49页
        2.3.2 XPS,SIMS results第49-54页
        2.3.3 AFM and WCA results第54-56页
        2.3.4 Mechanical behavior and stability第56-57页
        2.3.5 Adhesion,proliferation and staining of endothelium cell第57-59页
        2.3.6 Macrophages evaluation and tissue response第59-62页
        2.3.7 Conjugation of heparin and bioactivity assay第62-63页
    2.4 DISCUSSION第63-68页
    2.5 CONCLUSION第68-69页
CHAPTER 3 HEPARINIZED MUSSEL-INSPIRED COATING BARING AMINE GROUP FOR MULTI-FUNCTIONALIZATION OF VASCULAR STENT第69-95页
    3.1 INTRODUCTION第69-71页
    3.2 EXPERIMENTAL SECTION第71-76页
        3.2.1 Preparation of PDAM/HD coating第71页
        3.2.2 Characterization of PDAM/HD coating第71页
        3.2.3 Heparin conjugation and quantification第71-72页
        3.2.4 Hemocompatibility evaluation第72-73页
        3.2.5 Endothelium cell evaluation第73-74页
        3.2.6 Smooth muscle cell evaluation第74-75页
        3.2.7 Competitive Adhesion of ECs and SMCs第75页
        3.2.8 In vivo Subcutaneous Implantation Studies第75页
        3.2.9 Statistical analysis第75-76页
    3.3 RESULTS ANALYSIS第76-91页
        3.3.1 Characterization of Hep-PDAM/HD第76-78页
        3.3.2 Hemocompatibility evalution第78-82页
        3.3.3 Endothelial cell evalution第82-86页
        3.3.4 Smooth muscle cell evalution第86-87页
        3.3.5 Competitive Adhesion of ECs and SMCs第87-89页
        3.3.6 In vivo Subcutaneous Implantation Studies第89-91页
    3.4 DISCUSSION第91-94页
    3.5 CONCLUSION第94-95页
CHAPTER 4 BIOMIMETIC DESIGN OF NO-GENERATING COATINGS FORIMPROVING THE PERFORMANCE OF VASCULAR STENT第95-122页
    4.1 INTRODUCTION第95-98页
    4.2 EXPERIMENTAL SECTION第98-102页
        4.2.1 Preparation of PDAM/HD Coating第98页
        4.2.2 S-S and Se-Se Conjugation第98-99页
        4.2.3 Preparation of PDAM@Cu coatings第99页
        4.2.4 Characterization of the Coatings第99页
        4.2.5 NO Catalytic Release第99-100页
        4.2.6 Hemocompatibility Evaluation第100页
        4.2.7 Smooth muscle cell evaluation第100-101页
        4.2.8 Endothelium cell evaluation第101页
        4.2.9 Macrophage evaluation and In vivo animal tests第101-102页
        4.2.10 Statistical Analysis第102页
    4.3 RESULTS AND DISCUSSION第102-120页
        4.3.1 Characterization of S-S@PDAM/HD and Se-Se@PDAM/HD Coatings第102-105页
        4.3.2 NO Catalytic Release第105-109页
        4.3.3 Hemocompatibility Evaluation第109-112页
        4.3.4 Characterization of PDAM@Cu coatings第112-114页
        4.3.5 NO Catalytic Release第114-115页
        4.3.6 Hemocompatibility and enhanced cGMP expression第115-120页
    4.4 CONCLUSION第120-122页
CHAPTER 5 SUMMARY AND OUTLOOK第122-125页
    5.1 SUMMARY第122-123页
    5.2 OUTLOOK第123-125页
ACKNOWLEDGEMENTS第125-127页
REFERENCES第127-143页
ABBREVIATION LIST第143-145页
SCIENTIFIC ACHIEVEMENTS第145-149页

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