| Abbreviations | 第1-5页 |
| 摘要 | 第5-6页 |
| Abstract | 第6-7页 |
| Introduction | 第7-8页 |
| Methods | 第8-11页 |
| Animals and operation | 第8-9页 |
| Nociceptive behavior induced by acetic acid | 第9-10页 |
| Isolation of the dorsal root ganglia neurons | 第10页 |
| Electrophysiological recordings | 第10-11页 |
| Drug application | 第11页 |
| Data analysis | 第11页 |
| Results | 第11-17页 |
| Sex difference occurred in the nociceptive response evoked by acetic acid in rats | 第11-12页 |
| Estrogen and ERα involved in the enhanced sensitivity to the acetic acid-induced nociceptive response in female rats | 第12-13页 |
| E2 exacerbated nociceptive response to intraplantar injection of acetic acid in male rats | 第13-14页 |
| E2 potentiated proton-gated currents in female rat dorsal root ganglia neurons | 第14-15页 |
| Concentration-response relationship for proton-gated currents with and without pretreatment of E2 | 第15-16页 |
| The receptor and intracellular signal mechanisms underlying potentiation of proton-gated currents by E2 | 第16页 |
| E2 increased proton-induced membrane excitability of female rat dorsal root ganglia neurons | 第16-17页 |
| Discussion | 第17-21页 |
| References | 第21-25页 |
| Figure legends | 第25-37页 |
| 附录 | 第37-38页 |
| 综述 | 第38-53页 |
| 参考文献 | 第45-53页 |
| 攻读学位期间取得的学术成果 | 第53-54页 |
| 致谢 | 第54页 |
