| 摘要 | 第4-8页 |
| ABSTRACT | 第8-9页 |
| Chapter1 Literature Review | 第13-43页 |
| 1.1 Summary of the characteristics and research status of Tibetan medicine in China | 第13-15页 |
| 1.2 Summary of current research status of Lignum Caraganae | 第15-17页 |
| 1.3 Chemical constituents of genus Caragana | 第17-35页 |
| 1.3.1 Flavonoids | 第17-25页 |
| 1.3.2 Stilbenes | 第25页 |
| 1.3.3 Terpenoids | 第25-31页 |
| 1.3.4 Phenylpropanoids | 第31页 |
| 1.3.5 Sterols | 第31-33页 |
| 1.3.6 Benzoates | 第33-35页 |
| 1.4 Summary of analysis methods of genus Caragana | 第35-38页 |
| 1.4.1 TLC | 第35-36页 |
| 1.4.2 UV | 第36-37页 |
| 1.4.3 HPLC | 第37页 |
| 1.4.4 HS-SPME-GC-MS | 第37-38页 |
| 1.5 On-line research progress of flavonoids | 第38-40页 |
| 1.6 Summary of research progress in metabolism of flavonoids | 第40-43页 |
| Chapter2 Phytochemical study of the red heartwoods of the stems and roots of Caragana jubata | 第43-57页 |
| 2.1 Introduction | 第43页 |
| 2.2 Experimental | 第43-47页 |
| 2.2.1 General | 第43-44页 |
| 2.2.2 Materials and chemicals | 第44页 |
| 2.2.3 Extraction and isolation | 第44-47页 |
| 2.2.4 Structural identification | 第47页 |
| 2.3 Results and discussion | 第47-55页 |
| 2.3.1 Structural identification of isolated compounds | 第49-51页 |
| 2.3.2 Identification data of the isolated compounds | 第51-55页 |
| 2.4 Conclusion | 第55-57页 |
| Chapter3 Studies on UV features and MS fragmentation patterns of flavonoids | 第57-73页 |
| 3.1 Introduction | 第57-59页 |
| 3.2 Experimental | 第59-61页 |
| 3.2.1 Materials and chemicals | 第59-61页 |
| 3.2.2 Instrumentation and chromatographic conditions | 第61页 |
| 3.2.3 Sample preparation | 第61页 |
| 3.3 Results and discussion | 第61-72页 |
| 3.3.1 UV features of six subtypes of flavonoids | 第61-63页 |
| 3.3.2 MS fragmentation patterns of six subtypes of flavonoids | 第63-72页 |
| 3.4 Conclusion | 第72-73页 |
| Chapter4 Rapid on-line characterization of target components from LignumCaraganae | 第73-89页 |
| 4.1 Introduction | 第73页 |
| 4.2 Experimental | 第73-76页 |
| 4.2.1 Materials and chemicals | 第73页 |
| 4.2.2 Instrumentation and chromatographic conditions | 第73-74页 |
| 4.2.3 Sample preparation | 第74页 |
| 4.2.4 Strategies for identification of the target compounds | 第74-76页 |
| 4.3 Results and discussion | 第76-82页 |
| 4.3.1 Optimization of UPLC and MS conditions | 第76-77页 |
| 4.3.2 Establishment of the supporting database | 第77页 |
| 4.3.3 Identification of chemical constituents in LIC extracts | 第77-82页 |
| 4.4 Conclusion | 第82-89页 |
| Chapter5 Identification of absorbed constituents and metabolites of LignumCaraganae in rats | 第89-97页 |
| 5.1 Introduction | 第89-90页 |
| 5.2 Experimental | 第90-91页 |
| 5.2.1 Materials and chemicals | 第90页 |
| 5.2.2 Sample preparation | 第90页 |
| 5.2.3 Animals and drug administration | 第90页 |
| 5.2.4 Biological samples collection and pretreatment | 第90-91页 |
| 5.2.5 Instrumentation and chromatographic conditions | 第91页 |
| 5.3 Results and discussion | 第91-94页 |
| 5.3.1 Establishment of potential Metabolites database | 第91-92页 |
| 5.3.2 Characterization of the metabolites in plasma | 第92页 |
| 5.3.3 Characterization of metabolites in urine | 第92-94页 |
| 5.4 Conclusion | 第94-97页 |
| References | 第97-109页 |
| Appendices | 第109-115页 |
| Notes on publications and participation in scientific research | 第115-117页 |
| Acknowledgements | 第117页 |
