| ABSTRACT | 第1-12页 |
| 摘要 | 第12-15页 |
| ABBREVIATIONS | 第15-29页 |
| CHALPTER 1:LITERATURE REVIEW | 第29-73页 |
| ·INTRODUCTION | 第29-33页 |
| ·DEFINITION OF D-LIMONENE | 第33-40页 |
| ·Physicochemical Proprieties | 第33-34页 |
| ·Biosynthesis of D-Limonene | 第34-35页 |
| ·Biological Activities of D-Limonene | 第35-38页 |
| ·Anticancer Activity | 第35-36页 |
| ·Antidiabetic Activity | 第36页 |
| ·Antioxidant Activity | 第36-37页 |
| ·Antimicrobial Activity | 第37-38页 |
| ·Mechanism of Antimicrobial Action | 第38-39页 |
| ·Applications of D-Limonene | 第39-40页 |
| ·INTRODUCTION OF GELS | 第40-46页 |
| ·Definition of Organogels | 第40-41页 |
| ·Organogelators | 第41-43页 |
| ·Classification of the Organogelators | 第41-42页 |
| ·Characterization of Organogels | 第42-43页 |
| ·Proprieties of Organogels | 第43-45页 |
| ·Biocompatibility | 第43-44页 |
| ·Chirality | 第44页 |
| ·Non-Birefringence | 第44页 |
| ·Optical Clarity | 第44页 |
| ·Thermo-Stability | 第44页 |
| ·Thermo-Reversibility | 第44-45页 |
| ·Viscoelasticity | 第45页 |
| ·Applications of Organogels in Food Industry | 第45-46页 |
| ·INTRODUCTION AND DEFINITION OF NANOEMULSIONS | 第46-58页 |
| ·Formation of Nanoemulsions | 第47-51页 |
| ·Low Energy Methods | 第47-49页 |
| ·Spontaneous Emulsification | 第47-48页 |
| ·Catastrophic Phase Inversion | 第48-49页 |
| ·High-Energy Methods | 第49-51页 |
| ·Homogenization by Sonication | 第49页 |
| ·Microfluidizer | 第49-50页 |
| ·High Pressure Homogenization | 第50-51页 |
| ·Characterization of Nanoemulsions | 第51-53页 |
| ·Dynamic Light Scattering | 第52页 |
| ·Scanning Electron Microscopy | 第52页 |
| ·Transmission Electron Microscopy | 第52页 |
| ·Zeta Potential | 第52-53页 |
| ·Stability of Nanoemulsions | 第53-55页 |
| ·Ostwald Ripening | 第53-54页 |
| ·Coalescence and Flocculation | 第54页 |
| ·Creaming | 第54-55页 |
| ·Application of Nanoemulsions in Food Industry | 第55-58页 |
| ·Antimicrobial Systems | 第55-57页 |
| ·Transdermal Delivery Systems | 第57页 |
| ·Bioavailability | 第57-58页 |
| ·COMBINATION OF ESSENTIAL OILS AND THEIR BIOACTIVE COMPOUNDS | 第58-61页 |
| ·Combination Test Method | 第59-61页 |
| ·THE SCOPE OF THETHESIS | 第61页 |
| REFERENCES | 第61-73页 |
| CHAPTER 2:PREPARATION AND CHARACTERIZATION OF D-LIMONENE ORGANOGEL | 第73-85页 |
| ·BACKGROUND | 第73-74页 |
| ·EXPERIMENTAL MATERIALS AND EQUIPMENTS | 第74-75页 |
| ·Experimental Materials | 第74页 |
| ·Experimental Equipments | 第74-75页 |
| ·PREPARATION METHODS | 第75-76页 |
| ·Determination of the Critical Gelation Concentration(CGC) | 第75页 |
| ·Preparation of D-Limonene Organogel | 第75页 |
| ·Characterization of D-Limonene Organogel | 第75-76页 |
| ·The Microscopic Analysis | 第75-76页 |
| ·FTIR-Analysis | 第76页 |
| ·XRD Measuements | 第76页 |
| ·RESULTS AND DISCUSSIONS | 第76-82页 |
| ·Determination of the Critical Gelation Concentration | 第76-77页 |
| ·D-Limonene Organogel Preparation | 第77-78页 |
| ·D-Limonene Organogel Characterization | 第78-82页 |
| ·Organoleptic Test | 第78页 |
| ·Microscopic Analysis | 第78-79页 |
| ·XRD Measurement | 第79-81页 |
| ·FTIR Measurements | 第81-82页 |
| CONCLUSION | 第82页 |
| REFERENCES | 第82-85页 |
| CHAPTER 3:PRODUCTION AND STABILITY STUDIES OF D-LIMONENEORGANOGEL-BASED NANOEMULSION FORMED BY HIGH PRESSUREHOMOGENIZATION METHOD | 第85-107页 |
| ·BACKGROUND | 第85-86页 |
| ·EXPERIMENTAL MATERIALS AND EQUIPMENTS | 第86-87页 |
| ·Experimental Materials | 第86-87页 |
| ·Experimental Equipment | 第87页 |
| ·PREPARATION METHODS | 第87-88页 |
| ·Preparation of D-Limonene Organogel-Based Nanoemulsion | 第87-88页 |
| ·Particle Size Measurement | 第88页 |
| ·Turbidity Measurements | 第88页 |
| ·Storage Stability | 第88页 |
| ·RESULTS AND DISCUSSIONS | 第88-103页 |
| ·Effects of Organogelators on the Formation of D-Limonene Organogel-BasedNanoemulsion | 第88-91页 |
| ·Effects of Surfactants Type and Concentration on the Formation of D-LimoneneOrganogel-Based Nanoemulsion | 第91-96页 |
| ·Effects of the Type of Surfactant on the Formation of the Oil Droplets | 第91-94页 |
| ·Impact of the Surfactant Amount on the Particle Size Diameters Formation | 第94-96页 |
| ·Impacts of the Homogenization Pressure and Cycling Number on the D-Limonene Organogel-Based Nanoemulsion | 第96-99页 |
| ·Storage Stability of D-Limonene Organogel-Based Nanoemulsion | 第99-103页 |
| CONCLUSION | 第103页 |
| REFERENCES | 第103-107页 |
| CHAPTER 4:IMPROVING THE ANTIMICROBIAL ACTIVITY OF D-LIMONENE BY ITS INCORPORATION INTO AN ORGANOGEL-BASEDNANOEMULSION | 第107-123页 |
| ·BACKGROUND | 第107-109页 |
| ·EXPERIMENTAL MATERIALS AND EQUIPMENTS | 第109页 |
| ·Experimental Materials | 第109页 |
| ·Experimental Equipments | 第109页 |
| ·PREPARATION OF D-LIMONENE ORGANOGEL AND D-LIMONENE ORGANOGEL-BASED NANOEMULSION | 第109-110页 |
| ·PARTICLE SIZES MEASUREMENTS | 第110页 |
| ·TURBIDITY MEASUREMENTS | 第110页 |
| ·ANTIMICROBIAL ACTIVITY | 第110-111页 |
| ·Microbial Strains and Growth Cultures | 第110-111页 |
| ·Determination of MICs Values | 第111页 |
| ·MECHANISM OF THE ANTIMICROBIAL ACTION | 第111-112页 |
| ·Scanning Electrons Micrographs | 第111-112页 |
| ·Cells Constituents Release Determination | 第112页 |
| ·RESULTS AND DISCUSSIONS | 第112-120页 |
| ·Preparation and Characterization of D-Limonene Organogel-BasedNanoemulsion | 第112-115页 |
| ·The Effect of the Organogel-Based Nanoemulsion on the AntimicrobialEfficiency of D-Limonene | 第115-117页 |
| ·Mechanism of the Antimicrobial Action | 第117-120页 |
| ·Scanning Electrons Analysis | 第117-119页 |
| ·Determination of the Cells Constituent Release | 第119-120页 |
| CONCLUSION | 第120-121页 |
| REFERENCES | 第121-123页 |
| CHAPTER 5:IN VITRO ANTIMICROBIAL EFFICIENCY OF ε-POLYLYSINE AND D-LIMONENE AND THEIR COMBINATION AGAINSTFOUR FOOD-BORNE PATHOGENS | 第123-131页 |
| ·BACKGROUND | 第123页 |
| ·XPERIMENTAL AND EQUIPMENTS | 第123-124页 |
| ·Experimental Materials | 第124页 |
| ·Experimental Eq山pments | 第124页 |
| ·ANTIMICROBIAL ACTIVITY | 第124-126页 |
| ·MIC Measurement of D-Limonene and ε-Polylysine | 第124-125页 |
| ·Synergism Testing of ε-Polylysine and D-Limonene | 第125-126页 |
| ·RESULTS AND DISCUSSIONS | 第126-128页 |
| ·Antimicrobial Efficacy of ε-Polylysine and D-Limonene | 第126-127页 |
| ·Synergism Testing of ε-Polylysine and D-Limonene | 第127-128页 |
| CONCLUSION | 第128页 |
| REFERENCES | 第128-131页 |
| CHAPTER 6:PREPARATION OF D-LIMONENE NANOEMULSION WITHTHE INCLUSION OF ε-POLYLYSINE AND INVESTIGATION OF ITSANTIMICROBIAL ACTIVITY AND MECHANISM OF ACTION | 第131-149页 |
| ·BACKGROUND | 第131-133页 |
| ·EXPERIMENTAL MATERIALS AND EQUIPMENTS | 第133页 |
| ·Experimental Materials | 第133页 |
| ·Experimental Apparatus and Equipments | 第133页 |
| ·PREPARATION METHOD | 第133-136页 |
| ·Preparation of D-Limonene NanoemuIsion | 第133-134页 |
| ·Preparation of D-Limonene Nanoemulsion with the Inclusion Of ε-Polylysine | 第134页 |
| ·Particle Size Measurement | 第134-135页 |
| ·The Meament of Turbidity | 第135页 |
| ·Antimicrobial Efficiency | 第135-136页 |
| ·Determination of the MICs | 第135页 |
| ·Scanning Electron Microscopy | 第135-136页 |
| ·Cells Constituent Release Determination | 第136页 |
| ·RESULTS AND DISCUSSIONS | 第136-145页 |
| ·D-limonene Nanoemulsion Preparation | 第136-137页 |
| ·The Impact of ε-Polylysine on the D-Limonene Nanoemulsion | 第137-139页 |
| ·Antimicrobial Efficiency of D-Limonene Nanoemulsion with the Inclusion of ε-Polylysine and their Comparative Study | 第139-141页 |
| ·Mechanism of D-Limonene Nanoemulsion with the Inclusion of ε-Polylysine | 第141-145页 |
| ·SEM Visualization | 第141-144页 |
| ·Cell Constituent Release Determination | 第144-145页 |
| CONCLUSION | 第145页 |
| REFERENCES | 第145-149页 |
| CHAPTER 7:CONCLUSION | 第149-151页 |
| LIST OF PUBLICATIONS | 第151页 |
| Publications in Process | 第151-153页 |
| ACKNOWLEDGMENT | 第153-155页 |
| Mohamed Reda Zahi (Author) | 第155-157页 |
| Doctor Professor Pingyu Wan (First Supervisor) | 第157-159页 |
| Doctor Professor Qipeng Yuan (Second Supervisor) | 第159-160页 |
| 博士研究生学位论文笞辩委员会决议书 | 第160-161页 |
