| 摘要 | 第8-10页 |
| Abstract | 第10-11页 |
| Chapter 1: Introduction | 第20-24页 |
| 1.1 Introduction | 第20-22页 |
| 1.2 Research Objectives | 第22页 |
| 1.3 Research problems | 第22页 |
| 1.4 Thesis Outline | 第22-24页 |
| Chapter 2: Literature Review | 第24-52页 |
| 2.1 Introduction | 第24-26页 |
| 2.2 Copolymers | 第26-27页 |
| 2.3 Glycopolymers | 第27-28页 |
| 2.4 Atom Transfer Radical Polymerization | 第28-34页 |
| 2.4.1 Components of Atom Transfer Radical Polymerization | 第30-33页 |
| 2.4.1.1 Monomers | 第30-31页 |
| 2.4.1.2 Initiators | 第31-32页 |
| 2.4.1.3 Catalyst | 第32页 |
| 2.4.1.4 Ligand | 第32页 |
| 2.4.1.5 Solvents | 第32页 |
| 2.4.1.6 Reaction Temperature and Reaction Time | 第32-33页 |
| 2.4.2 Mechanism of Atom Transfer Radical Polymerization | 第33-34页 |
| 2.5 Preparation of Triblock Copolymer and Glycopolymer | 第34-35页 |
| 2.6 Self-Assembly of Block Copolymers Micelles | 第35-38页 |
| 2.7 Stimuli-Responsive Delivery and Glycopolymer Delivery | 第38-40页 |
| 2.7.1 The pH Differences for Stimuli-Responsive Delivery | 第39页 |
| 2.7.2 Temperature Differences for Stimuli-Responsive Delivery | 第39-40页 |
| 2.8 The pH-Responsive Polymeric Nanocarriers | 第40-41页 |
| 2.9 The pH-Responsive Polymer–Drug Conjugates | 第41-42页 |
| 2.10 The pH-Responsive Micellar Delivery Systems | 第42页 |
| 2.11 The pH-Responsive Dendrimers | 第42-43页 |
| 2.12 Double Hydrophilic Block Copolymer Micelles | 第43-44页 |
| 2.13 Drug Delivery Systems | 第44-51页 |
| 2.13.1 Anticancer Drug (Doxorubicin) | 第45-46页 |
| 2.13.2 Doxorubicin Loading Capacity and Encapsulation Efficiency | 第46-47页 |
| 2.13.3 Preparation of DOX-Loaded Tumor Targeted Polymeric Micelles | 第47页 |
| 2.13.4 Drug Loading | 第47-49页 |
| 2.13.4.1 Magnetic Nanoparticles | 第48-49页 |
| 2.13.5 Drug Release Behavior of Doxorubicin-Loaded Nanoparticles | 第49-51页 |
| 2.13.5.1 Thermo-Responsive Hydrogels | 第49-50页 |
| 2.13.5.2 Microspheres of biodegradable polymers | 第50-51页 |
| 2.14 Conclusion | 第51-52页 |
| Chapter 3: Investigation of pH-Responsive Block Glycopolymers with Random and BlockArchitectures for Loading and Release of Doxorubicin | 第52-76页 |
| 3.1 Introduction | 第52-54页 |
| 3.2 Experiments | 第54-59页 |
| 3.2.1 Materials | 第54-55页 |
| 3.2.2 Preparation of PEG-b-P(DEA-co-GAMA) glycopolymers with random architecture | 第55页 |
| 3.2.3 Preparation of PEG-b-PDEA-b-PGAMA glycopolymers with block architecture | 第55-56页 |
| 3.2.4 Preparation of micelles from pH-responsive block glycopolymers | 第56页 |
| 3.2.5 Measurement of critical micelle concentration of polymers | 第56页 |
| 3.2.6 Drug Loading Capacity and Encapsulation Efficiency | 第56-57页 |
| 3.2.7 Preparation of doxorubicin-loading nanoparticles | 第57页 |
| 3.2.8 The in-vitro release study | 第57-58页 |
| 3.2.9 Characterization | 第58-59页 |
| 3.3 Results and Discussion | 第59-74页 |
| 3.3.1 Synthesis of pH-Responsive Block Glycopolymers | 第59-61页 |
| 3.3.2 Nuclear Magnetic Resonance Spectra (~1H NMR) | 第61-63页 |
| 3.3.3 Gel permeation chromatography (GPC) | 第63-64页 |
| 3.3.4 Micellar Self-Assembly of pH-Responsive Block Glycopolymers | 第64-65页 |
| 3.3.5 Critical Micelle Concentration of polymers (CMC) | 第65-66页 |
| 3.3.6 Self-assembly | 第66-67页 |
| 3.3.7 Zeta-potential | 第67页 |
| 3.3.8 Dynamic light scattering (DLS) | 第67-68页 |
| 3.3.9 Transmission Electron Microscopy (TEM) | 第68页 |
| 3.3.10 Polymeric micelles for drug loading | 第68-70页 |
| 3.3.11 The in-vitro polymeric micelles for doxorubicin-loaded and release | 第70-72页 |
| 3.3.12 Release DOX from the PEG_(113)-b-P(DEA_(55)-co-GAMA_(12)), and PEG_(113)-b-PDEA_(55)-b-PGAMA_(15) micelles | 第72-74页 |
| 3.4 Conclusion | 第74-76页 |
| Chapter 4: Well-defined pH-responsive Block Glycopolymers different architectures forControlling Loading and Release Doxorubicin | 第76-101页 |
| 4.1 Introduction | 第76-78页 |
| 4.2 Experiments | 第78-83页 |
| 4.2.1 Materials | 第78页 |
| 4.2.2 Preparation of PEG-b-P(DEA-co-GAMA) glycopolymers with random architecture | 第78-79页 |
| 4.2.3 Preparation of PEG-b-PDEA-b-PGAMA glycopolymers with block architecture | 第79页 |
| 4.2.4 Preparation of PEG-b-PGAMA-b-PDEA glycopolymers with block architecture | 第79-80页 |
| 4.2.5 Preparation of micelles from pH-responsive block glycopolymers | 第80页 |
| 4.2.6 Measurement of critical micelle concentration of polymers | 第80页 |
| 4.2.7 Drug Loading Capacity and Encapsulation Efficiency | 第80-81页 |
| 4.2.8 Preparation of doxorubicin-loading nanoparticles | 第81页 |
| 4.2.9 The in-vitro release study | 第81-82页 |
| 4.2.10 Characterization | 第82-83页 |
| 4.3 Results and Discussion | 第83-100页 |
| 4.3.1 Synthesis of pH-Responsive Block Glycopolymers | 第83-84页 |
| 4.3.2 Nuclear Magnetic Resonance Spectra (~1H NMR) | 第84-87页 |
| 4.3.3 Gel permeation chromatography (GPC) | 第87-88页 |
| 4.3.4 Micellar Self-Assembly of pH-Responsive Block Glycopolymers | 第88-89页 |
| 4.3.5 Critical Micelle Concentration of polymers (CMC) | 第89-90页 |
| 4.3.6 Self-assembly | 第90-91页 |
| 4.3.7 Zeta-potential | 第91页 |
| 4.3.8 Dynamic light scattering (DLS) | 第91-92页 |
| 4.3.9 Transmission Electron Microscopy (TEM) | 第92页 |
| 4.3.10 Polymeric micelles for drug loading | 第92-94页 |
| 4.3.11 The in-vitro polymeric micelles for doxorubicin-loaded and release | 第94-97页 |
| 4.3.12 Release DOX from the PEG_(113)-b-P(DEA_(40)-co-GAMA_(30)), PEG_(113)-b-PDEA_(41)-b-PGAMA_(34), and PEG_(113)-b-PGAMA_(32)-b-PDEA_(38) micelles | 第97-100页 |
| 4.4 Conclusion | 第100-101页 |
| Chapter 5: Conclusions and future trends | 第101-104页 |
| Acknowledgements | 第104-105页 |
| References | 第105-112页 |
