| Abbreviations | 第1-9页 |
| 摘要 | 第9-12页 |
| Abstract | 第12-17页 |
| General background | 第17-23页 |
| Translational research | 第17-19页 |
| Translational research topics in the field of thoracic and cardiovascular surgery | 第19-23页 |
| Part I Cardiac Hypertrophy and Cardioprotection in a Mouse Model of Aortic Stenosis | 第23-41页 |
| Aortic Stenosis and Cardiac Hypertrophy | 第24-27页 |
| Mechanism of aortic stenosis-induced cardiac hypertrophy and heart | 第27-31页 |
| Current Treatments of Aortic Stenosis | 第31-34页 |
| Animal Models of Aortic Stenosis | 第34-36页 |
| Erythropoietin | 第36-39页 |
| Current Challenges and Our Hypothesis | 第39-41页 |
| Aims of the studies | 第41-42页 |
| Methods | 第42-50页 |
| Results | 第50-62页 |
| Discussion | 第62-74页 |
| Lesson 1: Recombinant human erythropoietin prevents left ventricula dysfunction and reduces left ventricular dilation induced by aortic stenosi | 第65-66页 |
| Lesson 2: Recombinant human erythropoietin reduces myocyte apoptosis in left ventricle of aortic stenosis. | 第66-68页 |
| Lesson 3: Recombinant human erythropoietin doesn’t prevent the development of cardiac hypertrophy, probably due to lack of its effects on intracellular signaling pathways of Stat3 and PI3K-Akt. | 第68-71页 |
| Lesson 4: Recombinant human erythropoietin has cardioprotective effects in maladaptive cardiac hypertrophy, probably by inhibiting nuclear factor-κB activation, phosphorylation of p38-MAPK pathway, and production of tumor necrosis factor-α. | 第71-74页 |
| Part II Lung Injury and Lung Protection in a Rabbit Model of Ischemia-Reperfusion | 第74-89页 |
| Ischemia-Reperfusion and Acute Lung Injury in Cardiothoracic Surgery | 第75-77页 |
| Animal Models of Lung Ischemia-Reperfusion Injury | 第77-82页 |
| Mechanisms of Ischemia-Reperfusion-Induced Tissue Damage in General | 第82-85页 |
| Current Treatments and Preventions | 第85-87页 |
| Current Challenges and Hypothesis | 第87-89页 |
| Aims of the studies | 第89-90页 |
| Methods | 第90-99页 |
| Results | 第99-108页 |
| Discussion | 第108-115页 |
| Lesson 5: Mitochondria plays critical role in ischemia-reperfusion-induced lung injury. | 第108-110页 |
| Lesson 6: Infant lung is more susceptible to ischemia-reperfusion-induced lung damage, probably due to lower antioxidant capacity than adults. | 第110-112页 |
| Lesson 7: Edaravone pretreatment attenuates ischemia-reperfusion-induced lung damage by protecting lung mitochondria, probably due to its effects on the activities of GSH-PX and SOD. | 第112-115页 |
| General discussion and conclusions | 第115-117页 |
| Review | 第117-126页 |
| References | 第126-154页 |
| Appendices | 第154-190页 |
| List of papers | 第190-191页 |
| Acknowledgements | 第191-192页 |
