| 摘要 | 第6-7页 |
| Abstract | 第7-8页 |
| List of breviation | 第9-12页 |
| Chapter 1: Introduction | 第12-41页 |
| Ⅰ. Organophosphorus pesticides Challenge: | 第12-13页 |
| Ⅱ. Organophosphorus insecticide: | 第13-18页 |
| Ⅱ.1. Chemical nature of organophosphorus insecticide: | 第13-14页 |
| Ⅱ.2. Some organophosphorus insecticides physico-chemials properties: | 第14-17页 |
| Ⅱ.3. Organophosphorus insecticides mechanism action | 第17-18页 |
| Ⅲ. Some neurotransmitters and his metabolisms: | 第18-19页 |
| Ⅳ. Evolution of acetylcholinesterase during life: | 第19-20页 |
| Ⅴ. Inhibition of acetylcholinesterase by organophosphorus insecticides | 第20-21页 |
| Ⅵ. Metabolism of organophosphorus insecticides and chlorpyrifos | 第21-23页 |
| Ⅶ. Acute neurotoxicity of organophosphorus insecticides | 第23-24页 |
| Ⅶ.1 Neurotoxicity | 第23页 |
| Ⅶ.2. Forms and causes of neurotoxicity produced by organophosphorusinsecticides | 第23-24页 |
| Ⅷ. Developmental neurotoxicity of organophosphorus insecticides | 第24-39页 |
| Ⅷ.1. Developmental neurotoxicity | 第24-26页 |
| Ⅷ.2. Development of the nervous system and the possible interferences withneurotoxic substances | 第26-39页 |
| Ⅸ. Objective of thesis | 第39-41页 |
| Chapter 2: Materials and Methods | 第41-48页 |
| Ⅰ. Materials | 第41-42页 |
| Ⅱ. Methods | 第42-48页 |
| Ⅱ.1. Perspective study by investigation | 第42-43页 |
| Ⅱ.2. Behavioral analysis in mouse | 第43-48页 |
| Chapter 3: Results and Analysis | 第48-63页 |
| Ⅰ. Results | 第48-56页 |
| Ⅰ.1. Perspective study by investigation | 第48-50页 |
| Ⅰ.2. Behavioral Analysis | 第50-56页 |
| Ⅱ. Discussion | 第56-63页 |
| Ⅱ.1. Neurotoxicity of OPs and their long-term effects | 第56-57页 |
| Ⅱ.2. Long-term neurobehavioral changes in children following exposure to OPs | 第57页 |
| Ⅱ.3. Long-term neurobehavioral changes following low-dose exposure to OPs | 第57-59页 |
| Ⅱ.4. Mecbanism of action of POs on neurobehavioral function | 第59-63页 |
| CHAPTER 4: Conclusion | 第63-65页 |
| Acknowledgements: | 第65-66页 |
| Reference | 第66-76页 |
| 附录 | 第76-78页 |
