| Abstract | 第4-5页 |
| 摘要 | 第6-8页 |
| Contents | 第8-10页 |
| CHAPTER 1: INTRODUCTION AND LITERATURE REVIEW | 第10-32页 |
| 1.1 INTRODUCTION | 第10-12页 |
| 1.2 MicroRNAs and Transcription factors in cardiovascular diseases | 第12-16页 |
| 1.3 Myocardial Infarction | 第16-19页 |
| 1.4 Ventricular Remodeling | 第19-21页 |
| 1.5 Current cardioprotective agents and therapeutic strategies essential in myocardial ischemia/reperfusion (I/R) injury | 第21-26页 |
| 1.6 Construction method of microRNA and Transcription factor co‐regulatory networks | 第26-31页 |
| 1.7 Study Objectives | 第31-32页 |
| CHAPTER 2: METHODOLOGY | 第32-36页 |
| 2.1 MI candidate genes and miRNAs | 第32页 |
| 2.2 Identification of miRNA and TF targets | 第32-34页 |
| 2.3 Network and hub analysis | 第34-35页 |
| 2.4 Functional Annotation of miRNA targets and pathway analysis | 第35-36页 |
| CHAPTER 3: RESULTS | 第36-55页 |
| 3.1 Basic information of MI related miRNAs and genes curated from literature and databases .. | 第36-42页 |
| 3.2 MI miRNA‐TF regulatory network and its characteristics | 第42-46页 |
| 3.3 Overlap between hub genes in the MI miRNA‐TF regulatory network | 第46-48页 |
| 3.4 Post‐MI subnetwork and overlap between MI hub and Post‐MI hub subnetworks | 第48-50页 |
| 3.5 Canonical pathway enrichment of miRNA and TF targets | 第50-52页 |
| 3.6 NFAT and Hypertrophy of the heart specific regulatory network in MI | 第52-53页 |
| 3.7 Cellular Model of essential components in MI progression | 第53-55页 |
| CHAPTER 4: DISCUSSION AND CONCLUSION | 第55-59页 |
| Acknowledgements | 第59-60页 |
| References | 第60-68页 |
