| Abstract | 第1-7页 |
| 中文摘要 | 第7-10页 |
| Chapter Ⅰ Brain Development & Chromatin Remodeling Protein in Development and Disease | 第10-33页 |
| ·Forebrain Development of mouse | 第10-15页 |
| ·Chromatin Remodeling Protein in Development and Disease | 第15-26页 |
| Reference | 第26-33页 |
| Chapter Ⅱ Material & Methods | 第33-59页 |
| ·Material | 第33-42页 |
| ·Methods | 第42-59页 |
| Chapter Ⅲ Identification of a novel Chd7 mutant mouse strain which recapitulated the phenotypes ofCHARGE syndrome | 第59-73页 |
| Introduction | 第59-60页 |
| Results | 第60-70页 |
| ·Identification of an ENU induced COA1 mutation in the gene Chd7 | 第60-63页 |
| ·The COA1 mutant mice were good models for CHARGE syndrome | 第63-70页 |
| Discussion | 第70-71页 |
| Reference | 第71-73页 |
| Chapter Ⅳ The Chd7~(COA1/+)mice displayed midline developmental defects | 第73-85页 |
| Introduction | 第73-74页 |
| Results | 第74-82页 |
| ·Chd7 was expressed in the CNS | 第74-76页 |
| ·Midline developmental defects of Chd7~(COA1/+)embryos | 第76-78页 |
| ·The choroid plexus formation was slightly disrupted in the Chd7~(COA1/+)embryos | 第78-79页 |
| ·The midline apoptosis in Chd7~(COA1/+)embryos was reduced while the proliferation rate was reserved | 第79-82页 |
| Discussion | 第82-83页 |
| Reference | 第83-85页 |
| ChapterⅤ Chd7 regulates the midline development via Bmp4 | 第85-103页 |
| Introduction | 第85-87页 |
| Results | 第87-97页 |
| ·Bmp4 signaling was altered in the midline of Chd7~(COA1/+)embryos | 第87-91页 |
| ·CHD7 regulated Bmp4 expression by antagonizing the inhibitory effect of a repressive element downstream of Bmp4 | 第91-97页 |
| Discussion | 第97-100页 |
| Reference | 第100-103页 |
| Acknowledgments | 第103-104页 |
| Publication | 第104-106页 |
