| 摘要 | 第11-12页 |
| Abstract | 第12页 |
| 1. INTRODUCTION AND LITERATURE REVIEW | 第13-47页 |
| 1.1 Glucose Homeostasis | 第14-22页 |
| 1.1.1 The role of the white adipose tissue (WAT) | 第15-16页 |
| 1.1.2 The role of the liver | 第16-18页 |
| 1.1.3 The role of the pancreas | 第18-19页 |
| 1.1.4 The role of the skeletal muscle | 第19-20页 |
| 1.1.5 The role of the brain | 第20-21页 |
| 1.1.6 The role of the kidney | 第21页 |
| 1.1.7 Tissues and organs interrelationships in glucose metabolism regulation | 第21-22页 |
| 1.2 Disturbances in whole-Body glucose homeostasis | 第22-47页 |
| 1.2.1 High fat diet (HFD) induced disturbances in glucose homeostasis | 第23-28页 |
| 1.2.1.1 Lipid metabolism in glucose homeostatic organs | 第23-25页 |
| 1.2.1.2 A high fat diet (HFD) induced disturbances in glucose homeostatic organs | 第25-28页 |
| 1.2.2 Di-(2-EthlyHexyl) Phthalate (DEHP) impaired glucose homeostasis | 第28-32页 |
| 1.2.2.1 DEHP metabolism in glucose homeostatic organs | 第28-30页 |
| 1.2.2.2 DEHP induced glucose homeostasis disturbances | 第30-32页 |
| 1.2.3 Metabolic disorders | 第32-42页 |
| 1.2.3.1 Type2 diabetes mellitus (T2DM) and obesity | 第33-38页 |
| 1.2.3.2 Type 1 diabetes mellitus (T1DM) | 第38-42页 |
| 1.2.4 Oxidative stress and antioxidants in diabetes mellitus | 第42-47页 |
| 1.2.4.1 Oxidative stress and reactive oxygen species | 第43-45页 |
| 1.2.4.2 Antioxidants and diabetes mellitus pathogenesis | 第45-47页 |
| 2. THE AIMS OF THE THESIS | 第47-48页 |
| 3. MATERIALS AND METHODS | 第48-52页 |
| 3.1 Chemicals and Diets | 第48页 |
| 3.2 Mice and Feeding Study | 第48-49页 |
| 3.3 Oral Glucose Tolerance Test(OGTT),Insulin Assay and Homeostasis Model Assessment Insulin Resistance(HOMA-IR) | 第49页 |
| 3.4 Tissue Homogenization,Pro-inflammatory Cytokine and Triglyceride Enzyme-Linked Immunosorbent Assays | 第49页 |
| 3.5 Serum TG Enzyme-Linked Immunosorbent Assay | 第49-50页 |
| 3.6 Determination of MDA Contents | 第50页 |
| 3.7 Total Glutathione Peroxidase Activity Determination | 第50页 |
| 3.8 Liver and Pancreas Histopathological Analysis | 第50-51页 |
| 3.9 Statistical Analysis | 第51-52页 |
| 4. RESULTS | 第52-63页 |
| 4.1 Effect of DEHP in combination with an HFD,and vitamin E on Glucose Metabolism | 第52-55页 |
| 4.1.1 Effects of DEHP in Combination with an HFD,and Vitamin E on Mice body Weight gain | 第52-53页 |
| 4.1.2 Effects of DEHP in Combination with the HFD,and vitamin E on Blood glucose levels, Insulin Concentrations,and HOMA-IR values | 第53-55页 |
| 4.2 Effects of DEHP in Combination with the HFD,and vitaminE on Pro-inflammatory Cytokines Expression in Target Organs | 第55-58页 |
| 4.3 Effects of DEHP in Combination with the HFD,and vitaminE on Plasma Lipid metabolism and Liver and Pancreas Histological Analysis | 第58-61页 |
| 4.3.1 Effects of DEHP,an HFD,and vitamin E on plasma,Liver,and pancreas TG | 第58-59页 |
| 4.3.2 DEHP,in combination with an HFD and Vitamin E effccts on Liver and Pancreas histological aspects | 第59-61页 |
| 4.4 Effects of DEHP in Combination with the HFD,and vitaminE on Oxidative Stress Profile in glucose homeostatic organs | 第61-63页 |
| 5. DISCUSSION | 第63-67页 |
| 6. CONCLUSION | 第67-69页 |
| REFERENCES | 第69-85页 |
| ACKNOWLEDGEMENT | 第85页 |
