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氯沙坦和辛伐他汀的联合治疗对兔动脉粥样硬的影响

中文摘要第4-6页
Abstract第6-7页
中文大摘要第8-17页
Abbreviation第17-19页
Preface第19-23页
Research purpose and methods第23-24页
Material and methods第24-28页
    1 Experimental Animals and Materials第24-28页
        1.1 Animals and food第24页
        1.2 Instruments,Reagents and drugs第24-25页
            1.2.1 Instruments and Equipment:Manufacturers第24页
            1.2.2 Laboratory reagents and drugs第24-25页
        1.3 Experimental Methods第25-27页
            1.3.1 Experimental animals feeding第25页
            1.3.2 Drugs Doses第25页
            1.3.3 Grouping experimental animals第25-26页
            1.3.4 Carotid artery endothelial injury第26页
            1.3.5 Administration of Drugs第26-27页
            1.3.6 Collection and Measurement of serum samples第27页
            1.3.7 Determination of intima to media thickness ratio第27页
        1.4 Statistical analysis第27-28页
Result第28-39页
    2.1 Effects on Body weight and health status第28页
    2.2 Treatment effect on serum lipid第28-30页
    2.3 Treatment effect on IL-6第30-31页
    2.4 Treatment effect on MCP-1第31-33页
    2.5 Treatment effect on serum PPARγ第33-34页
    2.6 Treatment effects on the Arterial intimal/medial thickness and ratio第34-35页
    2.7 Pathological observation第35-37页
        2.7.1 Gross examination第35-36页
        2.7.2 Microscopic examination第36-37页
    附图第37-39页
Discussion第39-47页
Summary第47-48页
Conclusion第48-49页
Reference第49-56页
Review第56-82页
    1 Introduction第56页
    2 Risk Factors of Atherosclerosis第56-60页
        2.1 hypercholesterolemia and Obesity第56-58页
        2.2 Hypertenson第58页
        2.3 Insulin resistance第58-59页
        2.4 Hemodynamics第59页
        2.5 Smoking第59页
        2.6 The role of homocysteine and infection in atherosclerosis第59-60页
    3 Serum markers of inflammation第60-63页
        3.1 C-reactive protein(CRP)第60-61页
        3.2 CD-40第61页
        3.3 Interleukin 18(IL-18)第61-62页
        3.4 Pregnancy-associated plasma protein A(PAPP-A)第62页
        3.5 Protease Activated Receptor(PAR)第62-63页
        3.6 Lipoprotein-associated phospholipase(Lp-PLA2)第63页
        3.7 Lectin-like oxidized low-density lipoprotein receptor-1(LOX-1)第63页
    4 Combination therapy of Atherosclerosis第63-69页
        4.1 Additive effects of Antihypertensive drugs第64-65页
        4.2 Statins combined with ACE inhibitors or ARBs vs.monotherapy第65-67页
        4.3 PPARs combined with ACE inhibitors or ARBs vs.monotherapy第67-69页
    5 Conclusion第69-70页
    Reference第70-82页
Acknowledgement第82页

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