| 中文摘要 | 第1-8页 |
| ABSTRACT | 第8-16页 |
| INTRODUCTION | 第16-26页 |
| MATERIALS AND METHODS | 第26-34页 |
| Reagents and Animals | 第26-27页 |
| Cell Culture and Ecto-ErbB4 Purified | 第27-28页 |
| Slice Preparation | 第28-29页 |
| Electrophysiological recording | 第29-32页 |
| Western blot analysis | 第32-33页 |
| Statistical analysis | 第33-34页 |
| RESULTS | 第34-62页 |
| 1. Amygdala exhibits comparatively high GABAergic activity | 第34-39页 |
| 2. LTP in LA is suppressed in normal conditions with compare to CA1, and thissuppression is removed by BMI | 第39-42页 |
| 3. NRG1-ErbB4 signaling inhibitor attenuates GABAA receptor-mediated synapticcurrents while its enhancer has no effects | 第42-44页 |
| 4. Both thalamus and cortex input LTP was induced in LA after perfusion ofEcto-ErbB4 | 第44-48页 |
| 5. Perfusion of ecto-ErbB4 do not further increase the extent of LTP in slicesGABA-mediated inhibition have been blocked | 第48-51页 |
| 6. ecto-ErbB4 treatment show normal basal synaptic transmission in LA | 第51-54页 |
| 7. ErbB4-/-HER4heart mice identification | 第54-55页 |
| 8. Changes in the balance of excitation and inhibition of ErbB4-/-HER4heart mice | 第55-59页 |
| 9. ErbB4~(-/-)HER4~(heart) mice exhibited LTP in LA | 第59-62页 |
| DISCUSSION | 第62-72页 |
| 1. LA exhibits robust GABAergic inhibiton with compare to other brain areas | 第62-64页 |
| 2. Block NRG1-ErbB4 signaling decreases the GABAergic inhibiton in the lateralamygdala | 第64-66页 |
| 3. NRG1/ErbB4 signaling contributes to the suppression of LTP in the lateralamygdala | 第66-68页 |
| 4. Blocking GABAA recepotor prevents suppression of LTP induction in the LA | 第68-72页 |
| SUMMARY | 第72-73页 |
| REFERENCE | 第73-88页 |
| 缩写词表 ABBREVIATIONS | 第88-91页 |
| 致谢 | 第91-93页 |
| 统计学证明 | 第93-94页 |
