| 摘要 | 第6-8页 |
| ABSTRACT | 第8-9页 |
| Chapter Ⅰ Introduction | 第14-16页 |
| 1.1 Background | 第14页 |
| 1.2 Statement of the problem | 第14页 |
| 1.3 Significance of the study | 第14-15页 |
| 1.4 Objectives of the study | 第15-16页 |
| Chapter Ⅱ Literature Review | 第16-37页 |
| 2.0 Limitations of conventional animal breeding | 第16页 |
| 2.1 Paradigm shift | 第16页 |
| 2.2 Genetic association analysis and its leverage on production | 第16-17页 |
| 2.3 Dairy Goat genetic studies and its significance | 第17页 |
| 2.4 Dairy goat milk fat and global health concern | 第17-18页 |
| 2.5 Fat Metabolism in ruminants | 第18-19页 |
| 2.6 Origin and composition of milk fatty acid | 第19-20页 |
| 2.7 Factors affecting milk fat composition | 第20-21页 |
| 2.8 Origin of SNPs | 第21-22页 |
| 2.9 SNP association analysis with milk production traits | 第22页 |
| 2.10 An overview on SNP scanning and genotyping Methods | 第22页 |
| 2.11 Relevance of SNPs in Animal production improvement | 第22-23页 |
| 2.12 Milk fat production candidate genes and their SNP association analysis | 第23-34页 |
| 2.13 Comparative economic analysis of genetic selection versus traditional selectionmethods | 第34-35页 |
| 2.14 Impacts,limitations and prospects of genetic association analysis | 第35-37页 |
| Chapter Ⅲ Materials and Methods | 第37-43页 |
| 3.1 Animals and Sampling | 第37页 |
| 3.2 Milk sampling,fat extraction and analysis | 第37-39页 |
| 3.3 DNA extraction,PCR condition,SNP detection and DNA sequencing | 第39-40页 |
| 3.4 DNA Genotyping,allele frequencies and haplotypes construction | 第40页 |
| 3.5 Statistical analysis | 第40-43页 |
| 3.5.1 Statistical analysis for candidate gene association analysis | 第40-41页 |
| 3.5.2 Statistical Analysis for factors affecting milk production traits | 第41-43页 |
| Chapter Ⅳ Results | 第43-87页 |
| 4.1 Descriptive statistics | 第43-47页 |
| 4.2 Effect of DIM on milk component and milk fat composition | 第47-50页 |
| 4.3 Effect of parity on milk components and milk fat composition | 第50-53页 |
| 4.4 Effect of herd on milk components and milk fat composition | 第53-56页 |
| 4.5 Effect of Td on milk components and milk fat composition | 第56-58页 |
| 4.6 Observed Correlations of individual and groups of fatty acids | 第58-62页 |
| 4.7 Genotyping results | 第62页 |
| 4.8 Association analysis results of FASN SNPs | 第62-64页 |
| 4.8.1 Effects of SNP1 on milk components | 第62-63页 |
| 4.8.2 Effect of SNP 2 on milk components | 第63页 |
| 4.8.3 Effect of SNP 3 on milk components | 第63-64页 |
| 4.9 Association analysis results of SCD1 SNPs | 第64-65页 |
| 4.9.1 Effect of SNP 4 on milk components | 第64页 |
| 4.9.2 Effect of SNP 5 on milk components | 第64-65页 |
| 4.10 Association analysis results of FASN haplotypes | 第65-87页 |
| 4.10.1 Effect of haplotype 1 on milk components | 第65-66页 |
| 4.10.2 Effect of haplotype 2 on milk components | 第66-87页 |
| Chapter Ⅴ Discussion | 第87-95页 |
| 5.1 Fatty acid correlations | 第87-89页 |
| 5.2 Effect of DIM on milk fat components | 第89-90页 |
| 5.3 Effect of parity on milk fat components | 第90-91页 |
| 5.4 Effect of Herd and Test day on milk fat composition | 第91-92页 |
| 5.5 Association analysis | 第92-95页 |
| Chapter Ⅵ Conclusion | 第95-96页 |
| References | 第96-107页 |
| Appendix | 第107-111页 |
| Acknowledgement | 第111页 |
