| 摘要 | 第1-11页 |
| Abstract | 第11-15页 |
| General background | 第15-29页 |
| Definition and classification of atrial fibrillation | 第15-16页 |
| Epidemiology and etiology of atrial fibrillation | 第16-18页 |
| Current therapies of atrial fibrillation | 第18-21页 |
| Atrial structural remodeling of atrial fibrillation | 第21-24页 |
| Regulatory pathways of atrial structural remodeling | 第24-29页 |
| Part I Heat Shock Proteins and Atrial Structural Remodeling | 第29-53页 |
| Background | 第30-32页 |
| Spontaneous restoration of SR after mitral valve surgery | 第30页 |
| Heat shock proteins | 第30-31页 |
| Heat shock proteins and atrial fibrillation | 第31页 |
| Current challenges and hypotheses | 第31-32页 |
| Methods | 第32-37页 |
| Results | 第37-47页 |
| Discussion | 第47-53页 |
| Lesson 1: Enhanced activity of HSF1 and discordant expression of Hsps in RAAs of patients with stable SR | 第47-48页 |
| Lesson 2: Regulation of myolysis, apoptosis, interstitial fibrosis and inflammation by heat shock proteins | 第48-50页 |
| Lesson 3: Predicting SR stabilization by preoperative circulating Hsp60 levels | 第50-51页 |
| Lesson 4: Potential clinical perspective | 第51-52页 |
| Lesson 5: Study limitations | 第52-53页 |
| Part II Natriuretic Peptides and Atrial Structural Remodeling | 第53-78页 |
| Background | 第54-56页 |
| Natriuretic peptides | 第54页 |
| Natriuretic peptides and atrial fibrillation | 第54-55页 |
| Current challenges and hypotheses | 第55-56页 |
| Methods | 第56-61页 |
| Results | 第61-72页 |
| Discussion | 第72-78页 |
| Lesson 6: Increased gene expression and protein content of pro-NPs in RAAs and plasma with AF | 第72-74页 |
| Lesson 7: Regulation of interstitial fibrosis to the pathogenesis and development of atrial fibrillation and to the discordance between transcripts and protein contents of pro-natriuretic peptides | 第74-76页 |
| Lesson 8: Contribution of preoperative medication to atrial and plasma pro-NPs protein contents | 第76-77页 |
| Lesson 9: Study limitations | 第77-78页 |
| Main conclusions | 第78-79页 |
| Review | 第79-102页 |
| References | 第102-136页 |
| Abbreviations | 第136-139页 |
| List of papers | 第139-141页 |
| Acknowledgements | 第141-142页 |
